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Literature summary for 5.3.99.3 extracted from
- Two types of microsomal prostaglandin E synthase: glutathione-dependent and -independent prostaglandin E synthases (1997), Biochem. Biophys. Res. Commun., 235, 148-152.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| GSH | two different types of prostaglandin E synthase: 1. GSH-dependent enzyme, 2. GSH-independent enzyme. The genitally organs, especially the deferent duct have mainly GSH-dependent prostaglandin E synthase activity. Heart, spleen and uterus have only the GSH-independent activity. In absence of reduced glutathione the enzyme from deferent duct shows only 3% of the activity in presence of reduced glutathione | Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0257 | - |
prostaglandin H2 | GSH-dependent enzyme from deferent duct | Rattus norvegicus | |
| 0.0826 | - |
prostaglandin H2 | GSH-independent enzyme from heart | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Rattus norvegicus | - |
| brain | - |
Rattus norvegicus | - |
| caput epididymis | - |
Rattus norvegicus | - |
| cauda epididymis | - |
Rattus norvegicus | - |
| cecum | - |
Rattus norvegicus | - |
| coagulating gland | - |
Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
| kidney | highest activity of nongenital organs | Rattus norvegicus | - |
| large intestine | - |
Rattus norvegicus | - |
| lung | - |
Rattus norvegicus | - |
| ovary | - |
Rattus norvegicus | - |
| small intestine | - |
Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
| stomach | - |
Rattus norvegicus | - |
| testis | - |
Rattus norvegicus | - |
| thymus | - |
Rattus norvegicus | - |
| uterus | - |
Rattus norvegicus | - |
| vas deferens | and other genital accessory organs | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Prostaglandin H2 | i.e. 15-hydroxy-9alpha,11alpha-peroxidoprosta-5,13-dienoic acid | Rattus norvegicus | Prostaglandin E2 | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 7 | GSH-dependent enzyme from deferent duct | Rattus norvegicus |
| 6 | 8 | GSH-independent enzyme from heart | Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 10 | pH 5: about 75% of maximal activity, pH 10: about 70% of maximal activity, GSH-dependent enzyme from deferent duct | Rattus norvegicus |
| 5 | 12 | pH 5: about 60% of maximal activity, pH 9: about 75% of maximal activity, pH 12: about 90% of maximal activity, GSH-independent enzyme from heart | Rattus norvegicus |
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Release 2023.1 (January 2023)
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