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Literature summary for 7.2.2.10 extracted from
- The plasma membrane Ca2+ ATPase of animal cells: structure, function and regulation (2008), Arch. Biochem. Biophys., 476, 65-74.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | activated by calmodulin | Homo sapiens |  |
| Calmodulin | activated by calmodulin | Mus musculus | |
| calpain | cleavage of PMCA by calpain activates it irreversibly | Homo sapiens | |
| calpain | cleavage of PMCA by calpain activates it irreversibly | Mus musculus | |
| phosphatidylinositol bisphosphate | the most active in stimulating PMCA activity | Homo sapiens | |
| phosphatidylinositol bisphosphate | the most active in stimulating PMCA activity | Mus musculus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| La3+ | - |
Homo sapiens | |
| La3+ | - |
Mus musculus | |
| orthovanadate | - |
Homo sapiens | |
| orthovanadate | - |
Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Homo sapiens | 5886 | - |
| plasma membrane | - |
Mus musculus | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | dependent on, at very low Ca2+ concentrations the PMCA is nearly inactive, unstimulated PMCA pumps have poor affinity for Ca2+ | Homo sapiens | |
| Ca2+ | dependent on, at very low Ca2+ concentrations the PMCA is nearly inactive, unstimulated PMCA pumps have poor affinity for Ca2+ | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | PMCA2 also has an important role in the regulation of Ca2+ concentration in the milk | ? | - |
? | |
| additional information | Mus musculus | PMCA2 also has an important role in the regulation of Ca2+ concentration in the milk | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Homo sapiens | P20020 | - |
- |
| Homo sapiens | Q01814 | - |
- |
| Homo sapiens | Q16720 | - |
- |
| Mus musculus | Q9R0K7 | isoform PMCA2 | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | PMCA can be phosphorylated both at serine/threonine and at tyrosine residues, the phosphorylation increases both the Vmax and the Ca2+ affinity of the pump | Homo sapiens |
| phosphoprotein | PMCA can be phosphorylated both at serine/threonine and at tyrosine residues, the phosphorylation increases both the Vmax and the Ca2+ affinity of the pump | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | PMCA1 is ubiquitous, but is expressed most abundantly in brain, lung and intestine | Homo sapiens | - |
| brain | PMCA1 is ubiquitous, but is expressed most abundantly in brain, lung and intestine. The PMCA3 and PMCA4 pumps are expressed in brain, the PMCA2 pump is a brain isoform. | Mus musculus | - |
| brain | the PMCA2 pump is a brain isoform | Homo sapiens | - |
| brain | the PMCA3 pump is expressed in brain | Homo sapiens | - |
| cerebellar Purkinje cell | PMCA2 is highly expressed in cerebellar Purkinje cells | Mus musculus | - |
| cerebellar Purkinje cell | PMCA2 is highly expressed in cerebellar Purkinje cells | Homo sapiens | - |
| erythrocyte | - |
Homo sapiens | - |
| erythrocyte | the PMCA4 pump is expressed in erythrocyte | Mus musculus | - |
| heart | - |
Homo sapiens | - |
| heart | PMCA2 is expressed at a lower level in the heart | Homo sapiens | - |
| heart | the PMCA4 pump is expressed in heart, PMCA2 is expressed at a lower level in the heart | Mus musculus | - |
| inner ear | PMCA2 is highly expressed in the hair cells of the inner ear | Mus musculus | - |
| inner ear | PMCA2 is highly expressed in the hair cells of the inner ear | Homo sapiens | - |
| intestine | - |
Homo sapiens | - |
| intestine | PMCA1 is ubiquitous, but is expressed most abundantly in brain, lung and intestine | Homo sapiens | - |
| intestine | PMCA1 is ubiquitous, but is expressed most abundantly in brain, lung and intestine. The PMCA4 pump is expressed in intestine. | Mus musculus | - |
| kidney | - |
Homo sapiens | - |
| kidney | the PMCA4 pump is expressed in kidney | Mus musculus | - |
| lung | PMCA1 is ubiquitous, but is expressed most abundantly in brain, lung and intestine | Mus musculus | - |
| lung | PMCA1 is ubiquitous, but is expressed most abundantly in brain, lung and intestine | Homo sapiens | - |
| mammary gland | the brain isoform PMCA2 pump is also expressed in the lactating mammary glands | Mus musculus | - |
| mammary gland | the brain isoform PMCA2 pump is also expressed in the lactating mammary glands | Homo sapiens | - |
| skeletal muscle | the PMCA3 and PMCA4 pumps are expressed in skeletal muscles | Homo sapiens | - |
| skeletal muscle | the PMCA3 and PMCA4 pumps are expressed in skeletal muscles | Mus musculus | - |
| skeletal muscle | the PMCA3 pump is expressed in skeletal muscles | Homo sapiens | - |
| smooth muscle | PMCA4 is the most abundant isoform in smooth muscles | Homo sapiens | - |
| smooth muscle | PMCA4 is the most abundant isoform in smooth muscles | Mus musculus | - |
| spermatozoon | - |
Homo sapiens | - |
| spermatozoon | the PMCA4 pump is expressed in spermatozoa | Mus musculus | - |
| stomach | - |
Homo sapiens | - |
| stomach | the PMCA4 pump is expressed in stomach | Mus musculus | - |
| testis | PMCA4 is expressed at particularly high levels in the testis (more than 90% of PMCA protein expressed there is isoform 4) | Homo sapiens | - |
| testis | PMCA4 is expressed at particularly high levels in the testis (more than 90% of PMCA protein expressed there is isoform 4) | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Ca2+/cis | the PMCA pump uses a molecule of ATP to transport one molecule of Ca2+ from the cytosol to the external environment | Homo sapiens | ADP + phosphate + Ca2+/trans | - |
? | |
| ATP + H2O + Ca2+/cis | the PMCA pump uses a molecule of ATP to transport one molecule of Ca2+ from the cytosol to the external environment | Mus musculus | ADP + phosphate + Ca2+/trans | - |
? | |
| additional information | PMCA2 also has an important role in the regulation of Ca2+ concentration in the milk | Homo sapiens | ? | - |
? | |
| additional information | PMCA2 also has an important role in the regulation of Ca2+ concentration in the milk | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ca2+ ATPase | - |
Homo sapiens |
| Ca2+ ATPase | - |
Mus musculus |
| plasma membrane calcium ATPase | - |
Homo sapiens |
| plasma membrane calcium ATPase | - |
Mus musculus |
| PMCA pump | - |
Homo sapiens |
| PMCA pump | - |
Mus musculus |
| PMCA1 | isoform | Mus musculus |
| PMCA1 | isoform | Homo sapiens |
| PMCA2 | isoform | Mus musculus |
| PMCA2 | isoform | Homo sapiens |
| PMCA3 | isoform | Mus musculus |
| PMCA3 | isoform | Homo sapiens |
| PMCA4 | isoform | Homo sapiens |
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