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Information on EC 5.6.1.8 - myosin ATPase
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5.6.1.8 myosin ATPaseIUBMB Comments
Proteins of the contractile apparatus of muscle and nonmuscle cells; myosin molecule consists of two heavy chains (about 200 kDa) and two pairs of light chains (15--27 kDa). The head region of the heavy chain contains actin- and ATP-binding sites. ATP hydrolysis provides energy for actomyosin contraction.
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Word Map
- 5.6.1.8
-
contractile
- cardiac
- fiber
- cytoskeleton
-
tension
- troponin
- ventricular
- f-actin
- myocardial
- artery
- hypertrophy
- myofibrillar
- junction
- microtubule
- cardiomyopathy
-
isometric
- cardiomyocytes
- myotubes
- myocytes
- calmodulin
-
striated
- soleus
-
cytokinesis
- myoblasts
-
myogenic
- sarcomere
-
myogenesis
-
actin-binding
-
sliding
- desmin
- dictyostelium
-
muscle-specific
- sarcoplasmic
-
slide
-
stiff
- rhoa
- ventricle
-
digitorum
- lateralis
-
vastus
- extensor
-
unload
- kinesins
- myocarditis
-
rock
-
twitch
- adhesions
- longus
-
microfilaments
-
myofibers
- medicine
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
+
=
+
+
+
+
myosin bound to actin filament at position n
=
+
+
myosin bound to actin filament at position n+1
Synonyms
myosin, actomyosin, heavy meromyosin, actomyosin atpase, nmiib, myosin-2, myosin-atpase, natural actomyosin, myosin 2, myosin ii atpase, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
actomyosin
actomyosin ATPase
EC 3.6.1.32
-
-
formerly
-
EC 3.6.4.1
-
-
formerly
-
matpase
-
-
-
-
myofibril ATPase
myosin
myosin ATPase
myosin II ATPase
myosin S1 ATPase
myosin-ATPase
actomyosin
-
-
-
-
myosin S1 ATPase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + myosin bound to actin filament at position n = ADP + phosphate + myosin bound to actin filament at position n+1
ATP + H2O + myosin bound to actin filament at position n = ADP + phosphate + myosin bound to actin filament at position n+1
terminal phosphate of triphosphate is removed
-
ATP + H2O + myosin bound to actin filament at position n = ADP + phosphate + myosin bound to actin filament at position n+1
kinetics
-
ATP + H2O + myosin bound to actin filament at position n = ADP + phosphate + myosin bound to actin filament at position n+1
kinetics and mechanical behaviour
-
ATP + H2O + myosin bound to actin filament at position n = ADP + phosphate + myosin bound to actin filament at position n+1
kinetics of activtation by actin
-
ATP + H2O + myosin bound to actin filament at position n = ADP + phosphate + myosin bound to actin filament at position n+1
combined quantum/classical mechanics study and catalytic mechanism, detailed overview and analysis
ATP + H2O + myosin bound to actin filament at position n = ADP + phosphate + myosin bound to actin filament at position n+1
the actin-activated release of inorganic phosphate from the acto myosin-ADP-phosphate complex is the rate-limiting step in the steady-state actomyosin ATPase cycle
ATP + H2O + myosin bound to actin filament at position n = ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphonic ester
-
-
-
-
hydrolysis of phosphoric ester
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SYSTEMATIC NAME
IUBMB Comments
ATP phosphohydrolase (actin-translocating)
Proteins of the contractile apparatus of muscle and nonmuscle cells; myosin molecule consists of two heavy chains (about 200 kDa) and two pairs of light chains (15--27 kDa). The head region of the heavy chain contains actin- and ATP-binding sites. ATP hydrolysis provides energy for actomyosin contraction.
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CAS REGISTRY NUMBER
COMMENTARY
9000-83-3
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
CTP + H2O + myosin bound to actin filament at position n
CDP + phosphate + myosin bound to actin filament at position n+1
GTP + H2O + myosin bound to actin filament at position n
GDP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ITP + H2O + myosin bound to actin filament at position n
IDP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
UTP + H2O + myosin bound to actin filament at position n
UDP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
nucleoside triphosphates are hydrolyzed in decreasing order: GTP, ITP, CTP, ATP, UTP
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
nucleoside triphosphates are hydrolyzed in the following order: GTP, ITP, CTP, ATP, UTP
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
ir
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
ATP binding site of myosin and catalytically active conformation, modeling and analysis of crystal structure, PDB 1VOM
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
ir
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
P13538; P02609; P02604
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
Delivering of F-actin to the lamella of migrating fibroblasts
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
Lethocerus griseus
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
ir
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
ir
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
246975, 246976, 246978, 246983, 246995, 246996, 246997, 247001, 247004, 247005, 733515, 733791, 735020, 749738, 749747, 749819, 749998, 751659
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
ir
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
ir
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
ir
CTP + H2O + myosin bound to actin filament at position n
CDP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
CTP + H2O + myosin bound to actin filament at position n
CDP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
additional information
?
-
during its contraction cycle, the myosin motor catalyzes the hydrolysis of ATP
-
-
?
additional information
?
-
P13538; P02609; P02604
myosin head (myosin subfragment 1, S1) consists of two major structural domains, the motor (or catalytic) domain and the regulatory domain. Functioning of the myosin head as a molecular motor is believed to involve a rotation of the regulatory domain (lever arm) relative to the motor domain during the ATPase cycle. This rotation can be accompanied by an interaction between the motor domain and the C-terminus of the essential light chain associated with the regulatory domain. During rotation, the regulatory domain acts as a semi-rigid lever arm, which amplifies and transmits conformational changes occurring in the motor domain during ATP hydrolysis, the sliding velocity of actin filaments in the in vitro motility assay strongly depends on the length of the lever arm. The essential light chain associated with the regulatory domain may play a crucial role in the motor function of the myosin head, taking part in the overall stabilization of the S1 molecule during the ATPase cycle
-
-
?
additional information
?
-
-
contraction of free-floating-fibroblast-populated collagen lattice through elongated fibroblasts and rapid myosin ATPase, requiring tyrosine phosphorylation. The mechanism for attached-delayed-released-fibroblast-populated collagen lattice contraction is through cell contraction by sustained myosin ATPase, involving tyrosine dephosphorylation
-
-
?
additional information
?
-
-
kinetics of muscle contraction and actomyosin NTP hydrolysis from rabbit using a series of metal-nucleotide substrates. The results are consistent with a dual rate-limitation model in which the rate of force recovery is limited by both NTP cleavage and phosphate release, with their relative contributions and apparent rate constants influenced by an intervening rapid force-generating transition
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
nucleoside triphosphates are hydrolyzed in the following order: GTP, ITP, CTP, ATP, UTP
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
ir
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
ir
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
P13538; P02609; P02604
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
Delivering of F-actin to the lamella of migrating fibroblasts
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
Lethocerus griseus
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
ir
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
ir
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
246975, 246976, 246978, 246983, 246995, 246996, 246997, 247001, 247004, 247005, 733515, 733791, 735020, 749738, 749747, 749819, 749998, 751659
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
ir
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
ir
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
?
ATP + H2O + myosin bound to actin filament at position n
ADP + phosphate + myosin bound to actin filament at position n+1
-
-
-
-
ir
additional information
?
-
during its contraction cycle, the myosin motor catalyzes the hydrolysis of ATP
-
-
?
additional information
?
-
P13538; P02609; P02604
myosin head (myosin subfragment 1, S1) consists of two major structural domains, the motor (or catalytic) domain and the regulatory domain. Functioning of the myosin head as a molecular motor is believed to involve a rotation of the regulatory domain (lever arm) relative to the motor domain during the ATPase cycle. This rotation can be accompanied by an interaction between the motor domain and the C-terminus of the essential light chain associated with the regulatory domain. During rotation, the regulatory domain acts as a semi-rigid lever arm, which amplifies and transmits conformational changes occurring in the motor domain during ATP hydrolysis, the sliding velocity of actin filaments in the in vitro motility assay strongly depends on the length of the lever arm. The essential light chain associated with the regulatory domain may play a crucial role in the motor function of the myosin head, taking part in the overall stabilization of the S1 molecule during the ATPase cycle
-
-
?
additional information
?
-
-
contraction of free-floating-fibroblast-populated collagen lattice through elongated fibroblasts and rapid myosin ATPase, requiring tyrosine phosphorylation. The mechanism for attached-delayed-released-fibroblast-populated collagen lattice contraction is through cell contraction by sustained myosin ATPase, involving tyrosine dephosphorylation
-
-
?
additional information
?
-
-
kinetics of muscle contraction and actomyosin NTP hydrolysis from rabbit using a series of metal-nucleotide substrates. The results are consistent with a dual rate-limitation model in which the rate of force recovery is limited by both NTP cleavage and phosphate release, with their relative contributions and apparent rate constants influenced by an intervening rapid force-generating transition
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
Mg2+
additional information
-
uterine myosin S1 ATPase activity does not depend on the concentration of Mg2+ in the presence of 5 mM Zn2+
Mg2+
required, Mg2+ coordination sphere, binding structure, overview
Mg2+
-
required, structure of myosin-2 complex with Mg2+-ADP-metavanadate
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2,4-dibromo-6-(3,4,5-tribromo-1-methyl-1H-pyrrol-2-yl)phenol
-
2-(3,5-dibromo-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole
-
-
2-(3,5-dibromo-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,5-dihydro-1H-pyrrole
-
-
2-(3,5-dichloro-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole
-
-