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Acetyl coenzyme A carboxylase
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acetyl coenzyme A carboxylase alpha
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acetyl-CoA carboxylase A
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acetyl-CoA carboxylase alpha
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acetyl-CoA carboxylase B
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acetyl-CoA carboxylase-2
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acetyl-CoA carboxylase-alpha
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acetyl-CoA-carboxylase
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acetyl-CoA/propionyl-CoA carboxylase
Acetyl-coenzyme A carboxylase
acetyl-coenzyme-A carboxylase
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acetylCoA carboxylase
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acyl coenzyme A carboxylase
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CAC1A
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gene name for subunit BCCP1
CAC1B
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gene name for subunit BCCP2
Carboxylase, acetyl coenzyme A
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ACACA
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ACC
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ACC
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structural organization of the ACC multienzyme into distinct biotinoyl carboxyl carrier protein, biotin carboxylase, and carboxyltransferase components
ACC
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structural organization of the ACC multienzyme into distinct biotinoyl carboxyl carrier protein, biotin carboxylase, and carboxyltransferase components
ACC1
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Acc1p
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ACC2
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AccA
subunit alpha
ACCase
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ACCase
Q3HWZ7, Q3HWZ8, Q3HWZ9, Q3HX00, Q3HX01, Q3HX02, Q3HX04, Q3HX05, Q3HX07, Q3HX09, Q3HX10 -
ACCase
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the ACCase that preferentially accepts acetyl-CoA as a substrate is defined as an acetyl-CoA carboxylase (ACC)
ACCB
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Acetyl CoA carboxylase
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Acetyl CoA carboxylase
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Acetyl CoA carboxylase
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acetyl-CoA carboxylase
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acetyl-CoA carboxylase
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acetyl-CoA carboxylase
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acetyl-CoA carboxylase 1
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acetyl-CoA carboxylase 1
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acetyl-CoA carboxylase 1
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acetyl-CoA carboxylase 1
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acetyl-CoA carboxylase 2
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acetyl-CoA carboxylase 2
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acetyl-CoA carboxylase 2
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acetyl-CoA carboxylase 2
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acetyl-CoA/propionyl-CoA carboxylase
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enzyme acts on both substrates
acetyl-CoA/propionyl-CoA carboxylase
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enzyme acts on both substrates
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acetyl-CoA/propionyl-CoA carboxylase
enzyme acts on both substrates
acetyl-CoA/propionyl-CoA carboxylase
enzyme acts on both substrates
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acetyl-CoA/propionyl-CoA carboxylase
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enzyme acts on both substrates
Acetyl-coenzyme A carboxylase
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Acetyl-coenzyme A carboxylase
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Acetyl-coenzyme A carboxylase
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Acetyl-coenzyme A carboxylase
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Acetyl-coenzyme A carboxylase
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BCCP1
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ACCase subunit
BCCP2
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ACCase subunit
Hfa1p
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additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
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additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
additional information
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
additional information
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
Q6JIZ0
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
additional information
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
the enzyme belongs to the family of biotin-dependent carboxylases
additional information
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c.f. EC 6.4.1.3
additional information
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c.f. EC 6.4.1.3
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additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
additional information
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the enzyme belongs to the family of biotin-dependent carboxylases
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
non-ordered ter ter mechanism
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
ordered bi bi uni uni ping-pong mechanism
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
ordered mechanism
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
catalytic regions analysis
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
catalytic regions analysis
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
catalytic regions analysis
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
catalytic regions analysis
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
molecular surface of the active site of the carboxyltransferase domain
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
substrate specificity, catalytic mechanism, and structural features
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
two-step reaction mechanism, structure-activity relationship
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
the enzyme proceeds through a hybrid (two-site) random Ter Ter mechanism, one that likely involves a two-step reaction at the biotin carboxylase domain
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
the enzyme is bifunctional exhibiting both acetyl-CoA carboxylase and propionyl-CoA carboxylase, EC 6.4.1.3, activities
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
catalytic regions analysis
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ATP + acetyl-CoA + hydrogencarbonate = ADP + phosphate + malonyl-CoA
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ATP + acetodethio-CoA + HCO3-
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?
ATP + acetyl-CoA + HCO3-
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ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
ATP + acetyl-CoA + HCO3-
ADP + phosphate + malonyl-CoA
ATP + acetyl-CoA + HCO3- + H+
ADP + phosphate + malonyl-CoA
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malonyl-CoA is a key metabolite in the fatty acid synthetic and oxidation pathways
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ATP + acetyl-CoA + hydrogencarbonate
ADP + phosphate + malonyl-CoA
ATP + biotin + HCO3-
ADP + ? + phosphate
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free biotin can be used as carboxyl acceptor with low activity
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?
ATP + butyryl-CoA + HCO3-
ADP + ethylmalonyl-CoA + phosphate
ATP + butyryl-CoA + HCO3- + H+
ADP + glutaryl-CoA + phosphate
ATP + propionyl-CoA + HCO3-
ADP + methylmalonyl-CoA + phosphate
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r
ATP + propionyl-CoA + HCO3-
ADP + phosphate + methylmalonyl-CoA
ATP + propionyl-CoA + HCO3- + H+
ADP + succinyl-CoA + phosphate
dATP + acetyl-CoA + HCO3-
dADP + phosphate + malonyl-CoA
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?
GTP + acetyl-CoA + HCO3-
GDP + phosphate + malonyl-CoA
n-butyryl-CoA + HCO3-
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4.6% activity compared to acetyl-CoA or propionyl-CoA
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?
UTP + acetyl-CoA + HCO3-
UDP + phosphate + malonyl-CoA
additional information
?
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ATP + acetyl-CoA + HCO3-
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key enzyme of 3-hydroxypropionate cycle
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?
ATP + acetyl-CoA + HCO3-
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n-butyryl-CoA (0.5 mM) is carboxylated at 4.6% compared to carboxylation of acetyl-CoA or propionyl-CoA
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?
ATP + acetyl-CoA + HCO3-
?
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synthesis of malonyl-CoA, which is used as the substrate in the biosynthesis of a variety of polyketide derivatives, including fatty acids, flavonoids, and stilbenoids. In addition malonyl-CoA is used as the substrate for the malonation of a variety of plant phytochemicals
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?
ATP + acetyl-CoA + HCO3-
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first committed step in biosynthesis of fatty acids, providing the essential substrate for fatty acid synthetase
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?
ATP + acetyl-CoA + HCO3-
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catalyzes the first committed step in the synthesis of fatty acids
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?
ATP + acetyl-CoA + HCO3-
?
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?
ATP + acetyl-CoA + HCO3-
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synthesis of malonyl-CoA is required for long-chain fatty acid and flavonoid biosynthesis
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?
ATP + acetyl-CoA + HCO3-
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key enzyme of de nove fatty acid biosynthesis
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?
ATP + acetyl-CoA + HCO3-
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synthesis of malonyl-CoA which is required for plastid localized fatty acid biosynthesis and for a variety of pathways in the cytoplasm including flavonoid biosynthesis
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?
ATP + acetyl-CoA + HCO3-
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?
ATP + acetyl-CoA + HCO3-
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synthesis of malonyl-CoA is required for long-chain fatty acid and flavonoid biosynthesis
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?
ATP + acetyl-CoA + HCO3-
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?
ATP + acetyl-CoA + HCO3-
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synthesis of malonyl-CoA is required for long-chain fatty acid and flavonoid biosynthesis
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?
ATP + acetyl-CoA + HCO3-
?
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?
ATP + acetyl-CoA + HCO3-
?
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key role in lipid metabolism
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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first committed step of fatty acid synthesis, physiological roles of the isozymes, regulation by RNA editing, post-transcriptional, and by stromal pH, photosynthetic redox cascade, and Mg2+ concentration, overview
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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the enzyme exhibits malonyl-CoA carboxylase and biotin carboxylase activity
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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first step in fatty acid biosynthesis via fatty acid synthase type II, overview
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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first committed step of fatty acid synthesis, physiological roles of the isozymes, regulation by RNA editing, post-transcriptional, and by stromal pH, photosynthetic redox cascade, and Mg2+ concentration, overview
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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the enzyme exhibits malonyl-CoA carboxylase and biotin carboxylase activity
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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regulation of isozyme expression and activity, overview
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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regulation of isozyme expression and activity
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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regulation of isozyme expression and activity
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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regulation of isozyme expression and activity, overview
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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first committed step of fatty acid synthesis
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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first step in fatty acid biosynthesis via fatty acid synthase type II, overview
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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first step in fatty acid biosynthesis, the enzyme expression is negatively autoregulated by subunit AccB
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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the enzyme exhibits malonyl-CoA carboxylase and biotin carboxylase activity
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
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the two-step reaction includes two catalytic activities at two catalytic sites: the biotin carboxylase and the carboxyltransferase, regulation of enzyme activity
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?
ATP + acetyl-CoA + HCO3-
ADP + malonyl-CoA + phosphate
6.4.1.2 acetyl-CoA carboxylase
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