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quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
contains cytochromes b-562, b-566 and c1, and a 2-iron ferredoxin. depending on the organism and the physiological conditions, either two or four protons are extruded from the cytoplasmic to the non-cytoplasmic compartment (cf.EC1.6.99.3 NADH2 dehydrogenase)
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quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
2 reaction mechanism variants, a fully active enzyme mechanism and a half-of-the sites mechanism of ubiquinol oxidation, switching between the two variants may regulate the enzyme, Glu272 and His181 are involved
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quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
alternating half-of-sites mechanism of ubiquinol oxidation
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quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
alternating half-of-the-sites mechanism of ubiquinol oxidation, enzyme links electron transfer from ubiquinol to cytochrome c by a protonmotive Q cycle mechanism in which ubiquinol is oxidized at one center in the enzyme, referred to as center P, und ubiquinone is re-reduced at a second center, referred to as center N
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quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
binding structure and mode of cytochrome c1 within the enzyme complex and cytochrome c during the catalytic reaction, direct heme-to-heme electron transfer from the enzyme complex cytochrome c1 to cytochrome c, half-of-the sites mechanism
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quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
reaction and substrate binding mechanism, overview, conformational changes at the binding site of inhibitor 5-n-heptyl-6-hydroxy-4,7-dioxobenzothiazole confirm the proton transfer pathway and reveal plasticity at the active site
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quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
substrate binding mechanism at the Qo site of the cytochrome bc1 complex
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quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
substrate binding site Qo structure, conformational changes upon inhibitor binding, overview
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quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
the Qo-cycle, overview, reaction mechanism involving cytochrome c, Glu295, and His161, electron transfer mechanism and formation of the ES complex involving a binding square, substrate binding mechanism at the Qo site of the cytochrome bc1 complex
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quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
current competing models for the two-electron oxidation of quinol QH2 at the cytochrome bc1 complex and related complexes impose distinct requirements for the reaction intermediate, the initial and rate-limiting step in quinol oxidation, both in the biological and biomimetic systems, involves electron and proton transfer, probably via a proton-coupled electron-transfer mechanism, a neutral semiquinone intermediate is formed in the biomimetic system, and oxidation of the QH*/QH2 couple for UQH2-0, but not TMQH2-0, exhibits an unusual and unexpected primary deuterium kinetic isotope effect on its Arrhenius activation energy, DELTA GTS, where DELTA GTS for the protiated form is larger than that for the deuterated form, detailed reaction mechanism, molecular modeling, electrochemical and computational study, overview
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quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
reaction mechanism, kinetic modeling
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quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
reaction mechanism, similar transition states mediate the Q-cycle and superoxide production by the cytochrome bc1 complex
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quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
reaction mechanism of superoxide generation during ubiquinol oxidation by the cytochrome bc1 complex
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quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
reaction mechanism of superoxide generation during ubiquinol oxidation by the cytochrome bc1 complex
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quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
reaction mechanism, structure-function analysis, overview
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quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
reaction mechanism, structure-function analysis, overview
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quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
reaction mechanism, structure-function analysis, overview
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quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
reaction mechanism, structure-function analysis, overview
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quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
reaction mechanism, structure-function analysis, overview
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quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
reaction mechanism, structure-function analysis, overview
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quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]
reaction mechanism, structure-function analysis, overview
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2,3-dimethoxy-5-methyl-6-(10-bromodecyl)-1,4-benzoquinol + 2 ferricytochrome c
2,3-dimethoxy-5-methyl-6-(10-bromodecyl)-1,4-benzoquinone + ferrocytochrome c + 2 H+[side 2]
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?
2,3-dimethoxy-5-methyl-6-decylbenzoquinol + 2 ferricytochrome c
2,3-dimethoxy-5-methyl-6-decylbenzoquinone + 2 ferrocytochrome c + 2 H+[side 2]
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?
2,3-dimethoxy-5-methyl-6-geranyl-1,4-benzoquinol + 2 ferricytochrome c
2,3-dimethoxy-5-methyl-6-geranyl-1,4-benzoquinone + 2 ferrocytochrome c + H+ [side 2]
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?
2,3-dimethoxy-5-methyl-6-geranyl-1,4-benzoquinol + 2 ferricytochrome c
2,3-dimethoxy-5-methyl-6-geranyl-1,4-benzoquinone + ferrocytochrome c + H+ [side 2]
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?
2-azido-3-methyl-5-methoxy-6-geranyl-1,4-benzoquinone + 2 ferricytochrome c1
2-azido-3-methyl-5-methoxy-6-geranyl-1,4-benzoquinol + 2 ferrocytochrome c1 + 2 H+[side 2]
2-[(7E,11E,15E,19E,23E,27E,31E,35E)-4-hydroxy-4,8,12,16,20,24,28,32,36,40-decamethyl-7,11,15,19,23,27,31,35,39-hentetracontanonaen-1-yl]-5,6-dimethoxy-3-methyl-1,4-benzenediol + 2 ferricytochrome c
2-[(7E,11E,15E,19E,23E,27E,31E,35E)-4-hydroxy-4,8,12,16,20,24,28,32,36,40-decamethylhentetraconta-7,11,15,19,23,27,31,35,39-nonaen-1-yl]-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione + 2 ferrocytochrome c + 2 H+
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ubiquinone-like compound with a hydroxyl-substituted side chain exhibits substrate efficiencies below that of native ubiquinone but significantly higher efficiency than alpha-tocopheryl quinone
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?
3-azido-2-methyl-5-methoxy-6-geranyl-1,4-benzoquinone + 2 ferricytochrome c1
3-azido-2-methyl-5-methoxy-6-geranyl-1,4-benzoquinol + 2 ferrocytochrome c1 + 2 H+
alpha-tocopheryl hydroquinone + ferricytochrome c + H+
alpha-tocopherol + ferrocytochrome c + H2O
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?
coenzyme Q1H2 + 2 ferricytochrome c
coenzyme Q1 + 2 ferrocytochrome c + 2 H+
cytochrome b561 + ?
?
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cytochrome b561, reduced upon flash excitation, is re-oxidized slowly even in the absence of antimycin
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?
cytochrome c551 + ?
?
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?
decyl-ubiquinol + ferricytochrome c
decyl-ubiquinone + ferrocytochrome c
decylbenzohydroquinol + ferricytochrome c
decylbenzohydroquinone + ferrocytochrome c + H+
decylplastoquinol + 2 ferricytochrome c
decylplastoquinone + 2 ferrocytochrome c + 2 H+
decylubiquinol + 2 ferricytochrome c
decylubiquinone + 2 ferrocytochrome c + 2 H+
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?
decylubiquinol + 2 ferricytochrome c
decylubiquinone + 2 ferrocytochrome c + H+ [side 2]
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?
decylubiquinol + ferricytochrome c
decylubiquinone + ferrocytochrome c
dihydroubiquinone + ferricytochrome c
ubiquinone + ferrocytochrome c + 2 H+
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?
menaquinol + 2 ferricytochrome c
menaquinone + 2 ferrocytochrome c + 2 H+
naphthoquinol + 2 ferricytochrome c
naphthoquinone + 2 ferrocytochrome c + 2 H+
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naphthoquinone is the pool quinone of the organism
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?
nonylubiquinol + 2 ferricytochrome c
nonylubiquinone + 2 ferrocytochrome c + 2 H+
plastohydroquinol + 2 ferricytochrome c
plastohydroquinone + 2 ferrocytochrome c + 2 H+
plastoquinol-1 + 2 ferricytochrome c
plastoquinone-1 + 2 ferrocytochrome c + 2 H+
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?
plastoquinol-9 + 2 ferricytochrome c
plastoquinone-9 + 2 ferrocytochrome c + 2 H+
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?
quinol + 2 ferricytochrome c
quinone + 2 ferrocytochrome c + 2 H+
quinol + 2 ferricytochrome c
quinone + 2 ferrocytochrome c + H+
quinol + 2 ferricytochrome c
quinone + 2 ferrocytochrome c + H+ [side 2]
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?
quinol + 2 ferricytochrome c1
quinone + 2 ferrocytochrome c1 + H+ [side 2]
quinol + 2 horse heart ferricytochrome c1
quinone + 2 horse heart ferrocytochrome c1 + H+ [side 2]
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?
rhodoquinol-3 + 2 ferricytochrome c
rhodoquinone-3 + 2 ferrocytochrome c + 2 H+
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a substrate-induced wQ-cycle bypass reaction leading to production of superoxide
i.e. 2-amino-5-farnesyl-3-methoxy-6-methyl-1,4-benzoquinone
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?
tetramethyl-p-benzoquinol + cytochrome c
tetramethyl-p-benzoquinone + reduced cytochrome c
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duroquinol
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?
ubideuteroquinol + cytochrome c
ubideuteroquinone + reduced cytochrome c
ubihydroquinol + cytochrome c
ubihydroquinone + reduced cytochrome c
ubiquinol + 2 4-carboxy-2,6-dinitrophenyllysine27-ferricytochrome c
ubiquinone + 2 4-carboxy-2,6-dinitrophenyllysine27-ferrocytochrome c + 2 H+
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cytochrome c from horse, modified at Lys27
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?
ubiquinol + 2 ferricyanide
ubiquinone + 2 ferrocyanide + 2 H+
ubiquinol + 2 ferricytochrome c
ubiquinone + 2 ferrocytochrome c + 2 H+
ubiquinol + 2 ferricytochrome c
ubiquinone + 2 ferrocytochrome c + 2 H+[side 2]
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?
ubiquinol + 2 ferricytochrome c2
ubiquinone + 2 ferrocytochrome c2 + 2 H+[side 2]
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?
ubiquinol + 2 ferricytochrome c552
ubiquinone + 2 ferrocytochrome c552 + 2 H+
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?
ubiquinol + cytochrome c2
ubiquinone + reduced cytochrome c2
ubiquinol + ferricytochrome b-561
ubiquinone + ferrocytochrome b-561
ubiquinol + ferricytochrome b-562
ubiquinone + ferrocytochrome b-562
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?
ubiquinol + ferricytochrome c
ubiquinone + ferrocytochrome c
ubiquinol + ferricytochrome c
ubiquinone + ferrocytochrome c + H+
ubiquinol + horse heart cytochrome c
?
ubiquinol + plastocyanin
?
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?
ubiquinol 10 + cytochrome c
ubiquinone 10 + reduced cytochrome c
ubiquinol 2 + cytochrome c
ubiquinone 2 + reduced cytochrome c
ubiquinol 3 + cytochrome c
ubiquinone 3 + reduced cytochrome c
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?
ubiquinol 4 + cytochrome c
ubiquinone 4 + reduced cytochrome c
ubiquinol 9 + cytochrome c
ubiquinone 9 + reduced cytochrome c
ubiquinol-1 + cytochrome c
ubiquinone-1 + reduced cytochrome c
ubiquinol-2 + 2 ferricytochrome c
ubiquinone-2 + 2 ferrocytochrome c + 2 H+
ubiquinol-2 + ferricytochrome c
ubiquinone-2 + ferrocytochrome c
ubiquinone-10 + ferricytochrome c
ubiquinol-10 + ferrocytochrome c + 2 H+
additional information
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2-azido-3-methyl-5-methoxy-6-geranyl-1,4-benzoquinone + 2 ferricytochrome c1
2-azido-3-methyl-5-methoxy-6-geranyl-1,4-benzoquinol + 2 ferrocytochrome c1 + 2 H+[side 2]
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?
2-azido-3-methyl-5-methoxy-6-geranyl-1,4-benzoquinone + 2 ferricytochrome c1
2-azido-3-methyl-5-methoxy-6-geranyl-1,4-benzoquinol + 2 ferrocytochrome c1 + 2 H+[side 2]
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?
2-azido-3-methyl-5-methoxy-6-geranyl-1,4-benzoquinone + 2 ferricytochrome c1
2-azido-3-methyl-5-methoxy-6-geranyl-1,4-benzoquinol + 2 ferrocytochrome c1 + 2 H+[side 2]
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?
3-azido-2-methyl-5-methoxy-6-geranyl-1,4-benzoquinone + 2 ferricytochrome c1
3-azido-2-methyl-5-methoxy-6-geranyl-1,4-benzoquinol + 2 ferrocytochrome c1 + 2 H+
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?
3-azido-2-methyl-5-methoxy-6-geranyl-1,4-benzoquinone + 2 ferricytochrome c1
3-azido-2-methyl-5-methoxy-6-geranyl-1,4-benzoquinol + 2 ferrocytochrome c1 + 2 H+
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?
3-azido-2-methyl-5-methoxy-6-geranyl-1,4-benzoquinone + 2 ferricytochrome c1
3-azido-2-methyl-5-methoxy-6-geranyl-1,4-benzoquinol + 2 ferrocytochrome c1 + 2 H+
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?
coenzyme Q1H2 + 2 ferricytochrome c
coenzyme Q1 + 2 ferrocytochrome c + 2 H+
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?
coenzyme Q1H2 + 2 ferricytochrome c
coenzyme Q1 + 2 ferrocytochrome c + 2 H+
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?
decyl-ubiquinol + ferricytochrome c
decyl-ubiquinone + ferrocytochrome c
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?
decyl-ubiquinol + ferricytochrome c
decyl-ubiquinone + ferrocytochrome c
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r
decyl-ubiquinol + ferricytochrome c
decyl-ubiquinone + ferrocytochrome c
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anti-cooperative oxidation of ubiquinol, reversible partial reaction
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?
decylbenzohydroquinol + ferricytochrome c
decylbenzohydroquinone + ferrocytochrome c + H+
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?
decylbenzohydroquinol + ferricytochrome c
decylbenzohydroquinone + ferrocytochrome c + H+
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?
decylplastoquinol + 2 ferricytochrome c
decylplastoquinone + 2 ferrocytochrome c + 2 H+
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?
decylplastoquinol + 2 ferricytochrome c
decylplastoquinone + 2 ferrocytochrome c + 2 H+
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?
decylubiquinol + ferricytochrome c
decylubiquinone + ferrocytochrome c
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?
decylubiquinol + ferricytochrome c
decylubiquinone + ferrocytochrome c
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horse heart cytochrome c, half of the center N sites was insensitive to decylubiquinol
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?
menaquinol + 2 ferricytochrome c
menaquinone + 2 ferrocytochrome c + 2 H+
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?
menaquinol + 2 ferricytochrome c
menaquinone + 2 ferrocytochrome c + 2 H+
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?
nonylubiquinol + 2 ferricytochrome c
nonylubiquinone + 2 ferrocytochrome c + 2 H+
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-
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?
nonylubiquinol + 2 ferricytochrome c
nonylubiquinone + 2 ferrocytochrome c + 2 H+
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?
plastohydroquinol + 2 ferricytochrome c
plastohydroquinone + 2 ferrocytochrome c + 2 H+
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?
plastohydroquinol + 2 ferricytochrome c
plastohydroquinone + 2 ferrocytochrome c + 2 H+
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?
quinol + 2 ferricytochrome c
quinone + 2 ferrocytochrome c + 2 H+
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?
quinol + 2 ferricytochrome c
quinone + 2 ferrocytochrome c + 2 H+
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-
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?
quinol + 2 ferricytochrome c
quinone + 2 ferrocytochrome c + 2 H+
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-
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?
quinol + 2 ferricytochrome c
quinone + 2 ferrocytochrome c + 2 H+
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-
-
-
?
quinol + 2 ferricytochrome c
quinone + 2 ferrocytochrome c + H+
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-
-
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?
quinol + 2 ferricytochrome c
quinone + 2 ferrocytochrome c + H+
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-
-
-
?
quinol + 2 ferricytochrome c1
quinone + 2 ferrocytochrome c1 + H+ [side 2]
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?
quinol + 2 ferricytochrome c1
quinone + 2 ferrocytochrome c1 + H+ [side 2]
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-
?
quinol + 2 ferricytochrome c1
quinone + 2 ferrocytochrome c1 + H+ [side 2]
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?
quinol + 2 ferricytochrome c1
quinone + 2 ferrocytochrome c1 + H+ [side 2]
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-
-
?
quinol + 2 ferricytochrome c1
quinone + 2 ferrocytochrome c1 + H+ [side 2]
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-
-
?
ubideuteroquinol + cytochrome c
ubideuteroquinone + reduced cytochrome c
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-
-
-
?
ubideuteroquinol + cytochrome c
ubideuteroquinone + reduced cytochrome c
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-
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?
ubihydroquinol + cytochrome c
ubihydroquinone + reduced cytochrome c
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-
-
-
?
ubihydroquinol + cytochrome c
ubihydroquinone + reduced cytochrome c
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-
-
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?
ubiquinol + 2 ferricyanide
ubiquinone + 2 ferrocyanide + 2 H+
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-
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?
ubiquinol + 2 ferricyanide
ubiquinone + 2 ferrocyanide + 2 H+
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?
ubiquinol + 2 ferricytochrome c
ubiquinone + 2 ferrocytochrome c + 2 H+
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?
ubiquinol + 2 ferricytochrome c
ubiquinone + 2 ferrocytochrome c + 2 H+
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?
ubiquinol + 2 ferricytochrome c
ubiquinone + 2 ferrocytochrome c + 2 H+
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?
ubiquinol + 2 ferricytochrome c
ubiquinone + 2 ferrocytochrome c + 2 H+
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?
ubiquinol + 2 ferricytochrome c
ubiquinone + 2 ferrocytochrome c + 2 H+
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-
395300, 396001, 439942, 439943, 439944, 439945, 439946, 439947, 439948, 439949, 439950, 439952, 439953, 439955, 439956, 439958, 439960, 439961, 439962, 439964, 439966, 439967, 439970, 439975, 439978, 439979, 439980, 439983, 439985, 439986, 439988, 439989, 439990, 439991, 439993, 439995, 440000, 440003, 440005, 440006, 440009, 440012, 440016, 440018, 440020, 440023, 440025, 440026, 440027, 440028, 440029, 440030, 440035, 685360, 686076, 725396 -
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?
ubiquinol + 2 ferricytochrome c
ubiquinone + 2 ferrocytochrome c + 2 H+
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interaction with ubiquinone at the QN site, overview
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?
ubiquinol + 2 ferricytochrome c
ubiquinone + 2 ferrocytochrome c + 2 H+
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the cyt bc1 complex catalyzes the antimycin-sensitive electron transfer reaction from lipophilic substrate ubiquinol to cytochrome c coupled with proton translocation across the membrane. As a result, for every quinol molecule oxidized, four protons are deposited to the positive side of the membrane and two molecules of cytochrome c are reduced. Key step in the Q-cycle mechanism is the separation of the two electrons of the substrate quinol at the QP site
interaction with ubiquinone at the QN site, overview
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?
7.1.1.8 quinol-cytochrome-c reductase
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