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Information on EC 5.6.1.5 - proteasome ATPase

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EC Tree
IUBMB Comments
Belongs to the AAA-type superfamily and, like EC 5.6.1.4 (minus-end-directed kinesin ATPase), is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome.
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Word Map
  • 5.6.1.5
  • atpases
  • ubiquitin-proteasome
  • misfolded
  • subcomplexes
  • polyubiquitinated
  • hexameric
  • disassembly
  • hslu
  • ubiquitin-dependent
  • ubiquitin-like
  • non-atpase
  • er-associated
  • multisubunit
  • deubiquitinase
  • proteasome-mediated
  • reticulum-associated
  • proteotoxic
  • escrt-iii
  • escrts
  • immunoproteasome
  • valosin-containing
  • retrotranslocation
  • katanin
  • deubiquitylating
  • pupylation
  • spastin
  • beta-type
  • zellweger
  • proteasome-associated
  • isopeptidase
  • medicine
The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
Reaction Schemes
+
+
=
+
+
unfolded polypeptide
Synonyms
aaa atpase, pa700, 19s regulatory particle, 19s proteasome, hslvu, tbp-1, 19s rp, rpt2a, 26s-proteasome, psmc5, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide
show the reaction diagram
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