EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
2.4.1.69 | type 1 galactoside alpha-(1,2)-fucosyltransferase |
prostate gland |
prostatic epithelial cells derived from patients with benign prostatic hyperplasia and from patients with prostatic cancer |
489361 |
2.4.2.10 | orotate phosphoribosyltransferase |
prostate gland |
normal tissue, hormone-sensitive prostate cancer (HSPC) or hormonerefractory prostate cancer (HRPC) tissue |
706025 |
2.4.2.28 | S-methyl-5'-thioadenosine phosphorylase |
prostate gland |
- |
637526, 637540, 736923 |
2.4.2.9 | uracil phosphoribosyltransferase |
prostate gland |
- |
675195 |
2.4.2.9 | uracil phosphoribosyltransferase |
prostate gland |
low level of expression |
675195 |
2.5.1.16 | spermidine synthase |
prostate gland |
- |
-, 489861, 489870, 489872, 489876, 639699, 639700, 639702, 639709, 661300, 661303 |
2.5.1.16 | spermidine synthase |
prostate gland |
ventral |
-, 639701, 639705 |
2.5.1.18 | glutathione transferase |
prostate gland |
- |
674060 |
2.5.1.22 | spermine synthase |
prostate gland |
- |
-, 489861, 489867, 489870, 489872 |
2.5.1.6 | methionine adenosyltransferase |
prostate gland |
mainly MAT2beta variant 1 |
686926 |
2.7.1.1 | hexokinase |
prostate gland |
intermediate expression in basal cells. Low to intermediate expression in stromal cells. Low expression in gland epithelium |
759579 |
2.7.1.147 | ADP-specific glucose/glucosamine kinase |
prostate gland |
- |
723169 |
2.7.1.154 | phosphatidylinositol-4-phosphate 3-kinase |
prostate gland |
isozyme PI3K-C2alpha inbasal epithelium and fibromuscular stroma, no isozyme PI3K-C2beta and isozyme p85 |
645046 |
2.7.1.31 | glycerate 3-kinase |
prostate gland |
- |
673281 |
2.7.10.2 | non-specific protein-tyrosine kinase |
prostate gland |
activity is significantly lower in prostate cancer tissue after androgen withdrawal and is also low in prostate cancer cell lines |
491949 |
2.7.11.1 | non-specific serine/threonine protein kinase |
prostate gland |
overexpression in malignant prostate glandular cells |
673433 |
2.7.11.12 | cGMP-dependent protein kinase |
prostate gland |
transition zone, distribution of cGKI |
673462 |
2.7.11.17 | Ca2+/calmodulin-dependent protein kinase |
prostate gland |
low expression level of CaM-K1delta |
664928 |
2.7.11.19 | phosphorylase kinase |
prostate gland |
- |
676038 |
2.7.11.24 | mitogen-activated protein kinase |
prostate gland |
- |
665029, 706581 |
2.7.4.6 | nucleoside-diphosphate kinase |
prostate gland |
high expression |
761777 |
2.8.2.2 | alcohol sulfotransferase |
prostate gland |
- |
738296, 761169, 761662, 761881 |
2.8.2.2 | alcohol sulfotransferase |
prostate gland |
prostate epithelial cells, prostate benign prostatic hyperplasia, prostate adenocarcinoma and LNCaP prostate adenocarcinoma cells |
675680 |
2.8.2.20 | protein-tyrosine sulfotransferase |
prostate gland |
- |
674372, 705836 |
3.1.1.4 | phospholipase A2 |
prostate gland |
- |
133865 |
3.1.21.7 | deoxyribonuclease V |
prostate gland |
- |
730709 |
3.1.3.1 | alkaline phosphatase |
prostate gland |
- |
94574 |
3.1.3.16 | protein-serine/threonine phosphatase |
prostate gland |
low enzyme expression level |
666301 |
3.1.3.2 | acid phosphatase |
prostate gland |
- |
134698, 134741, 134750, 134758, 134759, 134788, 664939 |
3.1.3.2 | acid phosphatase |
prostate gland |
age- and sex-dependent enzyme expression level, overview |
664547 |
3.1.3.2 | acid phosphatase |
prostate gland |
carcinoma prostate, benign prostate hypertrophy, normal prostate |
134726 |
3.1.3.2 | acid phosphatase |
prostate gland |
isoenzyme PAP-I and PAP-II |
134726 |
3.1.3.2 | acid phosphatase |
prostate gland |
low in fetal tissue, during development activity gradually increases |
134690 |
3.1.3.4 | phosphatidate phosphatase |
prostate gland |
- |
665805 |
3.1.3.4 | phosphatidate phosphatase |
prostate gland |
isoenzyme PAP2a |
134884 |
3.1.3.43 | [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase |
prostate gland |
- |
751678 |
3.1.3.46 | fructose-2,6-bisphosphate 2-phosphatase |
prostate gland |
- |
730530 |
3.1.3.66 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase |
prostate gland |
- |
714648, 751762, 752313 |
3.1.3.9 | glucose-6-phosphatase |
prostate gland |
- |
134945 |
3.1.4.17 | 3',5'-cyclic-nucleotide phosphodiesterase |
prostate gland |
epithelial, endothelial and smooth muscle cells |
669701 |
3.1.4.17 | 3',5'-cyclic-nucleotide phosphodiesterase |
prostate gland |
PDE11 |
668987 |
3.1.4.17 | 3',5'-cyclic-nucleotide phosphodiesterase |
prostate gland |
PDE11A2 |
668989 |
3.1.4.17 | 3',5'-cyclic-nucleotide phosphodiesterase |
prostate gland |
PDE11A4 |
668989 |
3.1.4.17 | 3',5'-cyclic-nucleotide phosphodiesterase |
prostate gland |
PDE11A4, strong antibody staining in the glandular epithelium |
668988 |
3.1.4.35 | 3',5'-cyclic-GMP phosphodiesterase |
prostate gland |
- |
711934 |
3.1.6.12 | N-acetylgalactosamine-4-sulfatase |
prostate gland |
- |
751772, 752087 |
3.1.6.4 | N-acetylgalactosamine-6-sulfatase |
prostate gland |
- |
751772 |
3.13.2.1 | adenosylhomocysteinase |
prostate gland |
- |
-, 137149 |
3.3.2.9 | microsomal epoxide hydrolase |
prostate gland |
- |
208880, 208881, 699759 |
3.4.11.2 | membrane alanyl aminopeptidase |
prostate gland |
- |
701038 |
3.4.13.18 | cytosol nonspecific dipeptidase |
prostate gland |
- |
36115 |
3.4.13.9 | Xaa-Pro dipeptidase |
prostate gland |
- |
36115 |
3.4.14.5 | dipeptidyl-peptidase IV |
prostate gland |
- |
697519 |
3.4.15.1 | peptidyl-dipeptidase A |
prostate gland |
- |
755108, 81211 |
3.4.17.21 | Glutamate carboxypeptidase II |
prostate gland |
- |
137211, 137212, 137213, 669595, 670794, 753584 |
3.4.17.21 | Glutamate carboxypeptidase II |
prostate gland |
epithelial cells |
668154 |
3.4.17.21 | Glutamate carboxypeptidase II |
prostate gland |
highly expressed, might be associated with prostate cancer progression |
755286 |
3.4.17.21 | Glutamate carboxypeptidase II |
prostate gland |
prostate form of the enzyme is termed prostate-specific membrane antigen |
667114, 670817 |
3.4.17.21 | Glutamate carboxypeptidase II |
prostate gland |
prostate-specific membrane antigen, PSMA |
670363 |
3.4.17.21 | Glutamate carboxypeptidase II |
prostate gland |
prostrate carcinoma cell line LNCaP |
137218, 137219, 137226, 137230 |
3.4.17.21 | Glutamate carboxypeptidase II |
prostate gland |
quantitative expression analysis |
670740 |
3.4.17.22 | metallocarboxypeptidase D |
prostate gland |
- |
755287 |
3.4.17.3 | lysine carboxypeptidase |
prostate gland |
benign hypertrophy |
36402 |
3.4.21.109 | matriptase |
prostate gland |
- |
683893 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
prostate gland |
- |
718165, 752620 |
3.4.21.122 | transmembrane protease serine 2 |
prostate gland |
- |
752699, 753731, 753735 |
3.4.21.122 | transmembrane protease serine 2 |
prostate gland |
and kidney, main expression sites. Expression is localized in the luminal epithelial cells |
754468 |
3.4.21.122 | transmembrane protease serine 2 |
prostate gland |
highest expression level, localized in luminal epithelial cells |
754468 |
3.4.21.122 | transmembrane protease serine 2 |
prostate gland |
highest expression of TMPRSS2 at the apical side of prostate and prostate cancer secretory epithelia and within the lumen of the glands |
764399 |
3.4.21.122 | transmembrane protease serine 2 |
prostate gland |
TMPRSS2 protein is abundantly expressed in the prostate. Protein is specifically localized to the secretory epithelium, with enhanced expression in the plasma membrane orientated towards the ductal lumen |
753135 |
3.4.21.35 | tissue kallikrein |
prostate gland |
- |
647332, 647503, 647523, 647536, 678468, 696531, 698327 |
3.4.21.35 | tissue kallikrein |
prostate gland |
low content |
647332 |
3.4.21.35 | tissue kallikrein |
prostate gland |
prostate-specific |
647531 |
3.4.21.42 | complement subcomponent C1s |
prostate gland |
- |
753047 |
3.4.21.73 | u-Plasminogen activator |
prostate gland |
- |
29578 |
3.4.21.77 | semenogelase |
prostate gland |
- |
680680 |
3.4.21.77 | semenogelase |
prostate gland |
concentration of enzyme in nonprostatic tissue represents less than 1% of the amount in normal prostate |
665230 |
3.4.21.B10 | neurosin |
prostate gland |
splice variant 3 is preferentially expressed in spinal cord, mammary, and salivary glands and to lesser extent in protstate |
663841 |
3.4.21.B12 | prostase |
prostate gland |
- |
680680, 681390, 717674, 718348 |
3.4.21.B12 | prostase |
prostate gland |
healthy prostate, highest amount of enzyme |
668285 |
3.4.21.B12 | prostase |
prostate gland |
predominant expression in basal cells of prostate gland |
668144 |
3.4.21.B12 | prostase |
prostate gland |
very low enzyme levels in healthy tissue |
731893 |
3.4.21.B39 | stratum corneum tryptic enzyme |
prostate gland |
- |
669444 |
3.4.21.B39 | stratum corneum tryptic enzyme |
prostate gland |
low expression |
670977 |
3.4.21.B42 | hippostasin |
prostate gland |
- |
718165 |
3.4.21.B42 | hippostasin |
prostate gland |
isozyme 2 |
679747 |
3.4.21.B43 | kallikrein 12 |
prostate gland |
- |
682623 |
3.4.21.B45 | kallikrein 14 |
prostate gland |
- |
667860 |
3.4.21.B6 | prostasin |
prostate gland |
- |
677453 |
3.4.21.B6 | prostasin |
prostate gland |
enzyme levels 20fold higher than in other tissues |
673905 |
3.4.21.B6 | prostasin |
prostate gland |
epithelial cell and duct |
651845 |
3.4.22.38 | cathepsin K |
prostate gland |
low activity |
30368 |
3.4.22.41 | cathepsin F |
prostate gland |
- |
137259 |
3.4.22.42 | cathepsin O |
prostate gland |
- |
137267 |
3.4.23.3 | gastricsin |
prostate gland |
- |
36848, 668809, 718005 |
3.4.23.45 | memapsin 1 |
prostate gland |
- |
668810 |
3.4.24.11 | neprilysin |
prostate gland |
high activity in glandular epithelium, weak activity in stroma |
670735 |
3.4.24.24 | gelatinase A |
prostate gland |
- |
752865 |
3.4.24.35 | gelatinase B |
prostate gland |
- |
670741 |
3.4.24.56 | insulysin |
prostate gland |
activity and amount of enzyme decrease in the cytosolic fraction with castration and increase with testpsterone treatment |
668492 |