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Literature summary for 3.1.6.4 extracted from

  • Bhattacharyya, S.; Feferman, L.; Tobacman, J.K.
    Chondroitin sulfatases differentially regulate Wnt signaling in prostate stem cells through effects on SHP2, phospho-ERK1/2, and Dickkopf Wnt signaling pathway inhibitor (DKK3) (2017), Oncotarget, 8, 242-260 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine in human prostate cancer tissues, the N-acetylgalactosamine-4-sulfatase ARSB activity is reduced and the galactosamine-N-acetyl-6-sulfatase GALNS activity is increased, compared to normal prostate tissue Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P34059
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-

Source Tissue

Source Tissue Comment Organism Textmining
prostate gland
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Homo sapiens
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General Information

General Information Comment Organism
physiological function in prostate stem cells, when N-acetylgalactosamine-4-sulfatase ARSB is reduced by silencing or galactosamine-N-acetyl-6-sulfatase GALNS is increased by overexpression, activity of non-receptor tyrosine phosphatase SHP2 declines, attributable to increased binding of SHP2 with C4S. This leads to increases in phospho-ERK1/2, Myc/Max nuclear DNA binding, DNA methyltransferase (DNMT) activity and expression, and methylation of the Dickkopf Wnt signaling pathway inhibitor (DKK)3 promoter and to reduced DKK3 expression. Since DKK3 negatively regulates Wnt/beta-catenin signaling, silencing of ARSB or overexpression of GALNS increases Wnt/beta-catenin signaling Homo sapiens