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Literature summary for 2.8.2.2 extracted from
- The important roles of steroid sulfatase and sulfotransferases in gynecological diseases (2016), Front. Pharmacol., 7, 30.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0023 | - |
dehydroepiandrosterone | isoform SULT2B1a, pH and temperature not specified in the publication | Homo sapiens |  |
| 0.0025 | - |
dehydroepiandrosterone | isoform SULT2A1, pH and temperature not specified in the publication | Homo sapiens | |
| 0.0044 | - |
dehydroepiandrosterone | isoform SULT2B1b, pH and temperature not specified in the publication | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 34000 | - |
x * 34000, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + 17alpha-hydroxypregnenolone | Homo sapiens | - |
adenosine 3',5'-bisphosphate + 17alpha-hydroxypregnenolone sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + dehydroepiandrosterone | Homo sapiens | - |
adenosine 3',5'-bisphosphate + dehydroepiandrosterone sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + pregnenolone | Homo sapiens | - |
adenosine 3',5'-bisphosphate + pregnenolone sulfate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O00204 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | fetal brain | Homo sapiens | - |
| colon | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| ovary | - |
Homo sapiens | - |
| placenta | - |
Homo sapiens | - |
| prostate gland | - |
Homo sapiens | - |
| small intestine | - |
Homo sapiens | - |
| uterine endometrium | - |
Homo sapiens | - |
| uterus | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + 17alpha-hydroxypregnenolone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 17alpha-hydroxypregnenolone sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + dehydroepiandrosterone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + dehydroepiandrosterone sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + pregnenolone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + pregnenolone sulfate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 34000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SULT2B1 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | the expression of SULT2B1 at the mRNA level is decreased in ovarian endometriosis compared to normal endometrium | down |
| Homo sapiens | the enzyme expression is upregulated in endometrial cancer | up |
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Release 2023.1 (January 2023)
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