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Information on EC 3.4.21.35 - tissue kallikrein

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.35 tissue kallikrein
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
Preferential cleavage of Arg-/- bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-/- or Leu-/-. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-/- bonds
Synonyms
prostate specific antigen, glandular kallikrein, renal kallikrein, trypsin-like serine protease, prokallikrein, salivary kallikrein, glandular kallikrein 2, protease m, urinary kallidinogenase, t-kininogenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Preferential cleavage of Arg-/- bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-/- or Leu-/-. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-/- bonds
show the reaction diagram