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Information on EC 3.3.2.9 - microsomal epoxide hydrolase

for references in articles please use BRENDA:EC3.3.2.9

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IUBMB Comments

This is a key hepatic enzyme that catalyses the hydrolytic ring opening of oxiranes (epoxides) and oxetanes to give the corresponding diols. The enzyme is involved in the metabolism of numerous substrates including the stereoselective hydrolytic ring opening of 7-oxabicyclo[4.1.0]hepta-2,4-dienes (arene oxides) to the corresponding trans-dihydrodiols. The reaction proceeds via a triad mechanism and involves the formation of an hydroxyalkyl-enzyme intermediate. Five epoxide-hydrolase enzymes have been identified in vertebrates to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol-5,6-oxide hydrolase).

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

Synonyms
microsomal, meh, microsomal epoxide hydrolase, ephx1, mephx, microsomal eh, jh epoxide hydrolase, juvenile hormone epoxide hydrolase, microsomal epoxide hydrolase 1, xenobiotic epoxide hydrolase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-({[(4-methoxyphenyl)methyl](methyl)amino}methyl)-2-methylpropane-1,3-diol
show the reaction diagram
(2)
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cis-stilbene oxide + H2O = (1R,2R)-1,2-diphenylethane-1,2-diol
show the reaction diagram
PATHWAY SOURCE
PATHWAYS