Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione | IC50: 0.02654 mM, PDE4A4 | Homo sapiens | |
dipyridamole | IC50: 0.00034 mM, PDE4A4 | Homo sapiens | |
sildenafil | IC50: 0.00315 mM, PDE4A4 | Homo sapiens | |
zaprinast | IC50: 0.00816 mM, PDE4A4 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme might be involved in multiple physiological processes in various organs via its ability to modulate intracellular cAMP and cGMP levels | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | epithelial and endothelial cells | Homo sapiens | - |
colon | epithelial cells and macrophages | Homo sapiens | - |
epidermis | - |
Homo sapiens | - |
kidney | tubule epithelial cells | Homo sapiens | - |
prostate gland | epithelial, endothelial and smooth muscle cells | Homo sapiens | - |
testis | Leydig cells and spermatogenic cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme might be involved in multiple physiological processes in various organs via its ability to modulate intracellular cAMP and cGMP levels | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDE11A | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00034 | - |
IC50: 0.00034 mM, PDE4A4 | Homo sapiens | dipyridamole | |
0.00315 | - |
IC50: 0.00315 mM, PDE4A4 | Homo sapiens | sildenafil | |
0.00816 | - |
IC50: 0.00816 mM, PDE4A4 | Homo sapiens | zaprinast | |
0.02654 | - |
IC50: 0.02654 mM, PDE4A4 | Homo sapiens | 3-isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione |