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Information on EC 3.1.4.35 - 3',5'-cyclic-GMP phosphodiesterase
for references in articles please use BRENDA:EC3.1.4.35
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EC Tree 3 Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.35 3',5'-cyclic-GMP phosphodiesterase
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
- 3.1.4.35
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erectile
- sildenafil
- arterial
- hypertension
- pulmonary
- tadalafil
- cyclase
- retinal
- vardenafil
-
erect
-
penile
-
guanylate
- photoreceptors
- prostate
- endothelin
-
vasodilator
-
placebo
-
pde5is
- camp
-
hemodynamic
- zaprinast
- transducin
-
cgmp-dependent
-
placebo-controlled
-
guanylyl
-
intercourse
- phosphodiesterases
- cavernosum
-
prostatectomy
- rhodopsin
- prostacyclins
-
double-blind
- nitroprusside
-
prostanoids
-
on-demand
-
satisfaction
- pkg
- bosentan
-
no-cgmp
-
intracavernosal
-
phototransduction
-
intracavernous
- libido
-
psychogenic
-
retropubic
-
urologist
-
6-minute
-
adulterated
- molecular biology
- medicine
- analysis
-
alpha-blocker
- peyronie
showSynonyms
phosphodiesterase type 5, phosphodiesterase-5, pde-5, phosphodiesterase 5, cgmp phosphodiesterase, pde5a, cyclic gmp phosphodiesterase, phosphodiesterase type-5, pde6b, cgmp-phosphodiesterase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3',5'-cyclic GMP phosphodiesterase
-
-
-
-
cG-PDE
cGMP phosphodiesterase
cGMP phosphodiesterase 6
cGMP-binding cGMP-specific phosphodiesterase
cGMP-PDE
cGMP-phosphodiesterase
cGMP-specific PDE
cGMP-specific phosphodiesterase
cGMP-specific phosphodiesterase type 9
cGMP-specific phosphodiesterase-5
cyclic 3',5'-GMP phosphodiesterase
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-
-
-
cyclic GMP phosphodiesterase
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-
-
-
cyclic guanosine 3',5'-monophosphate phosphodiesterase
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-
-
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cyclic guanosine 3',5'-phosphate phosphodiesterase
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-
-
-
guanosine 3',5'-cyclicmonophosphate-specific PDE
guanosine cyclic 3',5'-phosphate phosphodiesterase
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-
-
-
PDE
PDE-5
PDE5
PDE5A
PDE5A1
PDE6
PDE6B
PDE6C
PDE9
PDE9A
PDEgamma
phosphodiesterase 5
phosphodiesterase 9
phosphodiesterase cGMP
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-
-
-
phosphodiesterase type 5
phosphodiesterase type-5
phosphodiesterase, guanosine cyclic 3',5'-phosphate
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-
-
-
phosphodiesterase-5
phosphodiesterase-6
type 5 phosphodiesterase
cGMP phosphodiesterase
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-
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cGMP-PDE
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PDE5
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-
PDE5
key enzyme involved in the regulation of the smooth muscle relaxation associated to cGMP
PDE5
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PDEgamma
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PDE6 inhibitory gamma-subunit, PDEgamma keeps PDE6 inactive by binding tightly to the catalytic alpha,beta-subunits in the dark
PDEgamma
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the inhibitory subunit of the retinal cGMP phosphodiesterase 6 is a critical regulator of phototransduction
phosphodiesterase type 5
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-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
guanosine 3',5'-cyclic phosphate + H2O = GMP
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
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-
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-
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PATHWAY SOURCE
PATHWAYS
KEGG
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SYSTEMATIC NAME
IUBMB Comments
3',5'-cyclic-GMP 5'-nucleotidohydrolase
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CAS REGISTRY NUMBER
COMMENTARY
9068-52-4
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2'-O-anthraniloyl cGMP + H2O
2'-O-anthraniloyl GMP
-
Substrates: -
Products: -
Products: -
?
2'-O-anthraniloyl-cGMP + H2O
?
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Substrates: phosphorylation increases affinity for hydrolysis of 2'-O-anthraniloyl-cGMP by about 3fold
Products: -
Products: -
?
2'-O-anthraniloyl-cGMP + H2O
?
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Substrates: phosphorylation increases affinity for hydrolysis of 2'-O-anthraniloyl-cGMP by about 3fold
Products: -
Products: -
?
3',5'-cAMP + H2O
5'-AMP
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Substrates: activity with 3',5'-cAMP is higher than with 3',5'-cGMP, PDE6
Products: -
Products: -
?
3',5'-cAMP + H2O
5'-AMP
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Substrates: activity with 3',5'-cAMP is higher than with 3',5'-cGMP, PDE6
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
-
Substrates: -
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
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Substrates: allosteric cGMP-binding sites of PDE5 could regulate cGMP signaling by sequestering cGMP from cGMP-dependent protein kinase and perhaps from the PDE5 catalytic site as well. The cGMP sequestered by binding of cGMP to PDE5 R domain significantly dampens activation of cGMP-dependent protein kinase and hydrolysis of cGMP by PDE5 C domain
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
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Substrates: activity with 3',5'-cAMP is higher than with 3',5'-cGMP, PDE6
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
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Substrates: PDE5 and PDE6 show specificity for cGMP relative to cAMP
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
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Substrates: activity with 3',5'-cAMP is higher than with 3',5'-cGMP, PDE6
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
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Substrates: specific for 3',5'-cGMP
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
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667547, 691533, 691945, 692724, 693333, 694879, 710776, 711409, 711619, 711841, 711934, 711948, 712091, 713068, 750045
Substrates: -
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
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Substrates: selective for 3',5'-cGMP, PDE9
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
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Substrates: specific for 3',5'-cGMP
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
Substrates: PDE5 hydrolyses selectively 3',5'-cGMP with high affinity
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
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Substrates: PDE6 shows specificity for cGMP relative to cAMP
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
-
Substrates: -
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
Substrates: specific for 3',5'-cGMP
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
Substrates: PDE5A has a higher selectivity for cGMP due to much lower cAMP binding affinity
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
-
Substrates: -
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
Q2V2M6
Substrates: specific for 3',5'-cGMP
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
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135314, 135340, 691558, 694285, 711626, 711687, 711772, 711773, 711829, 711920, 711923, 712621, 712815, 713199, 750479
Substrates: -
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
Substrates: PDE5 specifically targets 3',5'-cyclic GMP
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
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Substrates: suPDE5 regulates cGMP levels in sperm, which in turn modulate sperm motility
Products: -
Products: -
?
3',5'-cGMP + H2O
5'-GMP
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Substrates: specific for 3',5'-cGMP, no activity with 3',5'-cAMP
Products: -
Products: -
?
3',5'-cGMP + H2O
guanosine 5'-phosphate
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Substrates: phosphodiesterase 5 converts the second messenger 3',5'-cGMP to its inactive form
Products: -
Products: -
?
cGMP + H2O
5'-GMP
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Substrates: degradation of intracellular cGMP
Products: -
Products: -
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
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Substrates: -
Products: -
Products: -
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
Substrates: -
Products: -
Products: -
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
Substrates: -
Products: -
Products: -
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
Substrates: -
Products: -
Products: -
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
Substrates: -
Products: -
Products: -
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
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Substrates: very low activity with cAMP
Products: -
Products: -
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
Substrates: -
Products: -
Products: -
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
Substrates: -
Products: -
Products: -
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
Substrates: -
Products: -
Products: -
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
Substrates: -
Products: -
Products: -
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
Substrates: -
Products: -
Products: -
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
Substrates: -
Products: -
Products: -
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
Substrates: -
Products: -
Products: -
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
Substrates: -
Products: -
Products: -
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
Substrates: -
Products: -
Products: -
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
Substrates: -
Products: -
Products: -
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
Substrates: -
Products: -
Products: -
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
Substrates: -
Products: -
Products: -
?
additional information
?
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Substrates: preincubation with cGMP increases catalytic activity for cGMP degradation, thus elevated cellular cGMP initiates a physiological negative feedback on the cGMP pathway by increasing the affinity of the PDE5 catalytic site for cGMP
Products: -
Products: -
?
additional information
?
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Substrates: tadalafil is not degraded by PDE5
Products: -
Products: -
?
additional information
?
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Substrates: analysis of diverse complxes formed by subunits Pgamma with GTP or GDP and outer segments, the complexes are extracted from membranes and isolated. Analysis of the function of the single complexes in PDE regulation, overview
Products: -
Products: -
?
additional information
?
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Substrates: interaction between the PDE6 gamma subunit with tubulin alpha and beta, specificity and mechanism, detailed overview
Products: -
Products: -
?
additional information
?
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Substrates: prenylation of the enzyme is required for plasma-membrane targeting
Products: -
Products: -
?
additional information
?
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Drosophila sp. (in: flies)
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Substrates: role for cG-PDE in modulating cGMP transport and efflux
Products: -
Products: -
?
additional information
?
-
Substrates: PDE6 contains two regulatory GAF domains, of which one (GAF A) binds cGMP and regulates the activity of the PDE6 holoenzyme
Products: -
Products: -
?
additional information
?
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Substrates: PDE6 contains two regulatory GAF domains, of which one (GAF A) binds cGMP and regulates the activity of the PDE6 holoenzyme
Products: -
Products: -
?
additional information
?
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Substrates: human chorionic gonadotropin reduces PDE5 expression and enzyme activity in smooth muscle cells, possibly through a pathway involving cAMP
Products: -
Products: -
?
additional information
?
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Substrates: PDE5 gene expression and activity are androgen-dependent in vas deferens
Products: -
Products: -
?
additional information
?
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Substrates: PDE5 may be involved in the cyclic nucleotide-mediated control of smooth muscle tone
Products: -
Products: -
?
additional information
?
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Substrates: PDE5 regulation of cGMP intracellular levels is not involved in the control of progression of smooth muscle cell cycle, but may represent one of the markers of the contractile phenotype
Products: -
Products: -
?
additional information
?
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Substrates: isoform PDE5 regulation of cGMP intracellular levels is not involved in the control of smooth muscle cell cycle progression, but may represent one of the markers of the contractile phenotype
Products: -
Products: -
?
additional information
?
-
-
Substrates: tadalafil is not degraded by PDE5
Products: -
Products: -
?
additional information
?
-
-
Substrates: PDE5 in Pukinje neurons may play a role in limiting the cGMP-mediated long-term depression response
Products: -
Products: -
?
additional information
?
-
-
Substrates: interaction between the PDE6 gamma subunit with tubulin alpha and beta, specificity and mechanism, detailed overview
Products: -
Products: -
?
additional information
?
-
-
Substrates: PDE5 gene expression and activity are androgen-dependent in vas deferens
Products: -
Products: -
?
additional information
?
-
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Substrates: in mammals the enzyme might play key roles in the aquisition and maintenance of the myoid cell contractile phenotype and more generally in the testis maturation
Products: -
Products: -
?
additional information
?
-
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Substrates: kinetics of a cellular nitric oxide/cGMP/phosphodiesterase-5 pathway
Products: -
Products: -
?
additional information
?
-
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Substrates: PDE5 controls the soluble but not the particulate pool of cGMP in rat cardiomyocytes
Products: -
Products: -
?
additional information
?
-
Substrates: cGMP levels in the spinal cord are controlled by a number of enzyme isoforms, that can be present in the same cell. Role of NO-cGMP signaling in nociceptive processing
Products: -
Products: -
?
additional information
?
-
-
Substrates: isoform PDE5 regulates bladder smooth muscle tone, strongly limiting the nitric oxide/cGMP signaling
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified