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airway trypsin-like protease precursor + H2O
?
-
residues 6-10
-
-
?
Ala-Thr-Pro-Lys-Ile-Phe-Asn + H2O
Ala-Thr-Pro-Lys + Ile-Phe-Asn
19% cleavage after 1 h incubation
-
-
?
collagen alpha1 (XII and XIX) chain precursor + H2O
?
-
residues 1838-1841
-
-
?
collagen alpha3 (IV) chain precursor + H2O
?
-
residues 832-835
-
-
?
Collagen IV + H2O
?
-
-
-
-
?
D-Ile-Pro-Arg-p-nitroanilide + H2O
D-Ile-Pro-Arg + p-nitroaniline
-
-
-
?
D-Val-Leu-Lys-thiobenzyl ester + H2O
D-Val-Leu-Lys + thiobenzyl alcohol
low activity
-
-
?
endothelin-2 precursor + H2O
?
-
residues 145-149
-
-
?
GDDSTPSILPAPRGYPGQV + H2O
GDDSTPSILPAPR + GYPGQV
the tethered ligand is GYPGQV
-
-
?
GPNSKGRSLIGRLDTPYGGC + H2O
SLIGRLDTPYGGC + RLDTPYGGC + GPNSKGRSLIG
the tethered ligand is SLIGRL
-
-
?
GSLR-4-nitroanilide + H2O
GSLR + 4-nitroaniline
-
-
-
?
GTNRSSKGRSLIGKVDGTSHVTGKGVT + H2O
GTNRSSKGR + SLIGKVDGTSHVTGKGVT
the tethered ligand is SLIGKV
-
-
?
HAI-1A + H2O
?
HAI-1A is extensively degraded when the protease:inhibitor stoichiometry is 1:1, or the enzyme is in excess. When the inhibitor is in excess, processing of HAI-1A generates fragments that likely mediate inhibition of pro-hepatocyte growth factor convertases
-
-
?
HANR-4-nitroanilide + H2O
HANR + 4-nitroaniline
-
-
-
?
HASR-4-nitroanilide + H2O
HASR + 4-nitroaniline
-
-
-
?
HAVR-4-nitroanilide + H2O
HAVR + 4-nitroaniline
-
-
-
?
HLNR-4-nitroanilide + H2O
HLNR + 4-nitroaniline
-
-
-
?
HLSR-4-nitroanilide + H2O
HLSR + 4-nitroaniline
-
-
-
?
HLVR-4-nitroanilide + H2O
HLVR + 4-nitroaniline
-
-
-
?
human proteinase-activated receptor 2 zymogen + H2O
mature human proteinase-activated receptor 2 + ?
unmasking the PAR2 receptor-activating sequence from a peptide precursor
-
-
?
HVNR-4-nitroanilide + H2O
HVNR + 4-nitroaniline
-
-
-
?
HVSR-4-nitroanilide + H2O
HVSR + 4-nitroaniline
-
-
-
?
HVVR-4-nitroanilide + H2O
HVVR + 4-nitroaniline
-
-
-
?
L-Gln-Gly-Asp-Lys-Ile-Ile-Asp + H2O
L-Gln-Gly-Asp-Lys + Ile-Ile-Asp
41% cleavage after 1 h incubation
-
-
?
L-Glu-Thr-Arg-Ile-Ile-Lys + H2O
L-Glu-Thr-Arg + Ile-Ile-Lys
55% cleavage after 1 h incubation
-
-
?
L-Ile-Gln-Ser-Arg-Ile-Val-Gly + H2O
L-Ile-Gln-Ser-Arg + Ile-Val-Gly
97% cleavage after 1 h incubation
-
-
?
L-Ile-Leu-Ser-Arg-Ile-Val-Gly + H2O
L-Ile-Leu-Ser-Arg + Ile-Val-Gly
87% cleavage after 1 h incubation
-
-
?
L-Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O
L-Pro-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
L-Pro-Phe-Arg-p-nitroanilide + H2O
L-Pro-Phe-Arg + p-nitroaniline
-
-
-
-
?
L-Ser-Ser-Ser-Arg-Ile-Ile-Asn + H2O
L-Ser-Ser-Ser-Arg + Ile-Ile-Asn
57% cleavage after 1 h incubation
-
-
?
laminin alpha-1 precursor + H2O
?
-
residues 1988-1991
-
-
?
laminin alpha-5 + H2O
?
-
-
-
-
?
MANR-4-nitroanilide + H2O
MANR + 4-nitroaniline
-
-
-
?
MASR-4-nitroanilide + H2O
MASR + 4-nitroaniline
-
-
-
?
matrillin-4 precursor + H2O
?
-
residues 178-182
-
-
?
MAVR-4-nitroanilide + H2O
MAVR + 4-nitroaniline
-
-
-
?
methoxy-succinyl-Arg-Pro-Tyr-p-nitroanilide + H2O
methoxy-succinyl-Arg-Pro-Tyr + p-nitroaniline
very low activity
-
-
?
MLNR-4-nitroanilide + H2O
MLNR + 4-nitroaniline
-
-
-
?
MLSR-4-nitroanilide + H2O
MLSR + 4-nitroaniline
-
-
-
?
MLVR-4-nitroanilide + H2O
MLVR + 4-nitroaniline
-
-
-
?
MVNR-4-nitroanilide + H2O
MVNR + 4-nitroaniline
-
-
-
?
MVSR-4-nitroanilide + H2O
MVSR + 4-nitroaniline
-
-
-
?
MVVR-4-nitroanilide + H2O
MVVR + 4-nitroaniline
-
-
-
?
NATLDPRSFLLRNPNDKYE + H2O
NATLDPR + SFLLRNPNDKYE
the tethered ligand is SFLLRN
-
-
?
polypeptide + H2O
peptides
-
-
?
pro-hepatocyte growth factor + H2O
?
the enzyme converts pro-hepatocyte growth factor to the two-chain heterodimer required for Met activation, while higher concentrations degrade the hepatocyte growth factor alpha-chain. When pro-hepatocyte growth factor is in vast excess it is activated by KLK14, and as the substrate concentration increases above a threshold level (protease:substrate ratio above 1:200), hepatocyte growth factor is inactivated
-
-
?
pro-KLK11 + H2O
KLK11 + ?
-
-
-
?
pro-KLK3 + H2O
KLK3 + ?
KLK3 is activated by cleavage after arginine at position 7
-
-
?
proprotein convertase subtilisin/kexin type 5 precursor + H2O
?
-
residues 371-375
-
-
?
proteinase-activated receptor 2 zymogen + H2O
mature proteinase-activated receptor 2 + ?
-
-
-
?
QAR-7-amido-4-methylcoumarin + H2O
?
-
-
-
?
rat proteinase-activated receptor 2 zymogen + H2O
mature rat proteinase-activated receptor 2 + ?
unmasking the PAR2 receptor-activating sequence from a peptide precursor
-
-
?
semenogelin I + H2O
?
-
-
-
?
semenogelin II + H2O
?
-
-
-
?
serin protease inhibitor Kazal-type 5 precursor + H2O
?
-
residues 1034-1037
-
-
?
tosyl-Gly-L-Pro-L-Arg-4-nitroanilide + H2O
tosyl-Gly-L-Pro-L-Arg + 4-nitroaniline
-
-
-
-
?
vascular endothelial growth factor receptor 3 precursor + H2O
?
-
residues 1126-1130
-
-
?
VGSLR-4-nitroanilide + H2O
VGSLR + 4-nitroaniline
-
-
-
?
villin-like protein + H2O
?
-
residues 61-65
-
-
?
WANR-4-nitroanilide + H2O
WANR + 4-nitroaniline
-
-
-
?
WASR-4-nitroanilide + H2O
WASR + 4-nitroaniline
-
-
-
?
WAVR-4-nitroanilide + H2O
WAVR + 4-nitroaniline
-
-
-
?
WLNR-4-nitroanilide + H2O
WLNR + 4-nitroaniline
-
-
-
?
WLSR-4-nitroanilide + H2O
WLSR + 4-nitroaniline
-
-
-
?
WLVR-4-nitroanilide + H2O
WLVR + 4-nitroaniline
-
-
-
?
WVNR-4-nitroanilide + H2O
WVNR + 4-nitroaniline
-
-
-
?
WVSR-4-nitroanilide + H2O
WVSR + 4-nitroaniline
-
-
-
?
WVVR-4-nitroanilide + H2O
WVVR + 4-nitroaniline
-
-
-
?
YAAR-4-nitroanilide + H2O
YAAR + 4-nitroaniline
-
-
-
?
YANR-4-nitroanilide + H2O
YANR + 4-nitroaniline
-
-
-
?
YASR-4-nitroanilide + H2O
YASR + 4-nitroaniline
-
-
-
?
YAVR-4-nitroanilide + H2O
YAVR + 4-nitroaniline
-
-
-
?
YLNR-4-nitroanilide + H2O
YLNR + 4-nitroaniline
-
-
-
?
YLSR-4-nitroanilide + H2O
YLSR + 4-nitroaniline
-
-
-
?
YLVR-4-nitroanilide + H2O
YLVR + 4-nitroaniline
-
-
-
?
YVNR-4-nitroanilide + H2O
YVNR + 4-nitroaniline
-
-
-
?
YVSR-4-nitroanilide + H2O
YVSR + 4-nitroaniline
-
-
-
?
YVVR-4-nitroanilide + H2O
YVVR + 4-nitroaniline
-
-
-
?
additional information
?
-
additional information
?
-
does not cleave L-Glu-Ser-Ser-Lys-Val-Leu-Asn, L-Ser-Cys-Ser-Gln-Ile-Ile-Asn, L-Glu-Gln-Asn-Lys-Leu-Val-His, L-Gln-Glu-Asp-Lys-Val-Leu-Gly, L-Asp-Thr-Arg-Ala-Ile-Gly, L-Asn-Asp-Thr-Arg-Leu-Asp-Pro, L-Asp-Glu-Asn-Lys-Ile-Ile-Gly, and L-Asp-Gly-Asp-Lys-Leu-Leu-Glu
-
-
?
additional information
?
-
-
does not cleave L-Glu-Ser-Ser-Lys-Val-Leu-Asn, L-Ser-Cys-Ser-Gln-Ile-Ile-Asn, L-Glu-Gln-Asn-Lys-Leu-Val-His, L-Gln-Glu-Asp-Lys-Val-Leu-Gly, L-Asp-Thr-Arg-Ala-Ile-Gly, L-Asn-Asp-Thr-Arg-Leu-Asp-Pro, L-Asp-Glu-Asn-Lys-Ile-Ile-Gly, and L-Asp-Gly-Asp-Lys-Leu-Leu-Glu
-
-
?
additional information
?
-
crucial cascade-mediated function of KLK14 in regulating the coagulation and liquefaction of human semen
-
-
?
additional information
?
-
-
crucial cascade-mediated function of KLK14 in regulating the coagulation and liquefaction of human semen
-
-
?
additional information
?
-
the enzyme activates the proteinase-activated receptor 2 recombinnatly expressed in rat and in human cells
-
-
?
additional information
?
-
-
the enzyme activates the proteinase-activated receptor 2 recombinnatly expressed in rat and in human cells
-
-
?
additional information
?
-
determination of substrate and cleavage site specificities of the enzyme using peptide fused to 4-nitroanilide as substrates, molecular modeling of preferred KLK14 substrates. The enzyme KLK14 displays a preference for Tyr and Trp at the P4 site
-
-
?
additional information
?
-
KLK14 can cleave synthetic peptides representing the cleavage-activation sequences of human proteinase-activated receptors PARs 1, 2 and 4 to unmask a receptor-activating sequence. Substrate specificity, overview. Analysis of processing of synthetic human and rat proteinase-activated receptor 2, PAR2, derived sequences, representing the cleavage activation domain of PAR2, by kallikrein 8 versus kallikrein 14. KLKs 8 and 14 can both cleave the synthetic PAR2 tethered ligand-containing synthetic peptides to unmask a potential receptor-activating sequence, but each KLK exhibits distinct signalling properties via PARs 1 and 2
-
-
?
additional information
?
-
-
KLK14 can cleave synthetic peptides representing the cleavage-activation sequences of human proteinase-activated receptors PARs 1, 2 and 4 to unmask a receptor-activating sequence. Substrate specificity, overview. Analysis of processing of synthetic human and rat proteinase-activated receptor 2, PAR2, derived sequences, representing the cleavage activation domain of PAR2, by kallikrein 8 versus kallikrein 14. KLKs 8 and 14 can both cleave the synthetic PAR2 tethered ligand-containing synthetic peptides to unmask a potential receptor-activating sequence, but each KLK exhibits distinct signalling properties via PARs 1 and 2
-
-
?
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Adenocarcinoma
High expression of KLK14 in prostatic adenocarcinoma is associated with elevated risk of prostate-specific antigen relapse.
Adenoma
Parallel overexpression and clinical significance of kallikrein-related peptidases 7 and 14 (KLK7 KLK14) in colon cancer.
Adenoma, Pleomorphic
Human kallikrein 14 (KLK14) expression in salivary gland tumors.
Breast Neoplasms
Enzymatic profiling of human kallikrein 14 using phage-display substrate technology.
Breast Neoplasms
Expression and enzymatic characterization of recombinant human kallikrein 14.
Breast Neoplasms
Expression of human Kallikrein 14 (KLK14) in breast cancer is associated with higher tumour grades and positive nodal status.
Breast Neoplasms
Human kallikrein 14: a new potential biomarker for ovarian and breast cancer.
Breast Neoplasms
MSR1 repeats modulate gene expression and affect risk of breast and prostate cancer.
Breast Neoplasms
Quantitative analysis of human kallikrein gene 14 expression in breast tumours indicates association with poor prognosis.
Breast Neoplasms
Quantitative expression analysis and study of the novel human kallikrein-related peptidase 14 gene (KLK14) in malignant and benign breast tissues.
Breast Neoplasms
Significant alterations in the expression pattern of kallikrein-related peptidase genes KLK4, KLK5 and KLK14 after treatment of breast cancer cells with the chemotherapeutic agents epirubicin, docetaxel and methotrexate.
Breast Neoplasms
The canine kallikrein-related peptidase 14: structural characterization, alternative splicing and differential expression in mammary cancer.
Carcinogenesis
Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells.
Carcinogenesis
Kallikrein-related peptidase signaling in colon carcinoma cells: Targeting proteinase-activated receptors (PARs).
Carcinogenesis
Kallikrein-related peptidase signaling in colon carcinoma cells: targeting proteinase-activated receptors.
Carcinogenesis
Parallel overexpression and clinical significance of kallikrein-related peptidases 7 and 14 (KLK7 KLK14) in colon cancer.
Carcinoma
Diagnostic and prognostic biomarker potential of kallikrein family genes in different cancer types.
Carcinoma
Effects of kallikrein-related peptidase 14 gene inhibition by small interfering RNA in ovarian carcinoma cells.
Carcinoma
Human kallikrein 14 (KLK14) expression in salivary gland tumors.
Carcinoma
Quantitative expression analysis and study of the novel human kallikrein-related peptidase 14 gene (KLK14) in malignant and benign breast tissues.
Carcinoma, Adenoid Cystic
Human kallikrein 14 (KLK14) expression in salivary gland tumors.
Carcinoma, Hepatocellular
Diagnostic and prognostic biomarker potential of kallikrein family genes in different cancer types.
Carcinoma, Mucoepidermoid
Human kallikrein 14 (KLK14) expression in salivary gland tumors.
Carcinoma, Renal Cell
Diagnostic and prognostic biomarker potential of kallikrein family genes in different cancer types.
Colonic Neoplasms
Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells.
Colonic Neoplasms
Kallikrein-related peptidase 7 (KLK7) is a proliferative factor that is aberrantly expressed in human colon cancer.
Colonic Neoplasms
Kallikrein-related peptidase signaling in colon carcinoma cells: Targeting proteinase-activated receptors (PARs).
Colonic Neoplasms
Kallikrein-related peptidase signaling in colon carcinoma cells: targeting proteinase-activated receptors.
Dermatitis, Atopic
Human tissue kallikrein expression in the stratum corneum and serum of atopic dermatitis patients.
Hereditary Complement Deficiency Diseases
Induction of complement c3a receptor responses by kallikrein-related peptidase 14.
Leukemia, Lymphocytic, Chronic, B-Cell
mRNA overexpression of kallikrein-related peptidase 14 (KLK14) is an independent predictor of poor overall survival in chronic lymphocytic leukemia patients.
Lung Neoplasms
Quantitative RT-PCR analysis and immunohistochemical localization of the kallikrein-related peptidases 13 and 14 in lung.
Neoplasm Metastasis
The molecular function of kallikrein-related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer.
Neoplasm, Residual
Advanced high-grade serous ovarian cancer: inverse association of KLK13 and KLK14 mRNA levels in tumor tissue and patients' prognosis.
Neoplasms
A Suite of Activity-Based Probes To Dissect the KLK Activome in Drug-Resistant Prostate Cancer.
Neoplasms
Advanced high-grade serous ovarian cancer: inverse association of KLK13 and KLK14 mRNA levels in tumor tissue and patients' prognosis.
Neoplasms
Cloning of a new member of the human kallikrein gene family, KLK14, which is down-regulated in different malignancies.
Neoplasms
Differential expression of the human kallikrein gene 14 (KLK14) in normal and cancerous prostatic tissues.
Neoplasms
Effects of kallikrein-related peptidase 14 gene inhibition by small interfering RNA in ovarian carcinoma cells.
Neoplasms
Enzymatic profiling of human kallikrein 14 using phage-display substrate technology.
Neoplasms
Expression and functional characterization of the cancer-related serine protease, human tissue kallikrein 14.
Neoplasms
Expression of human Kallikrein 14 (KLK14) in breast cancer is associated with higher tumour grades and positive nodal status.
Neoplasms
High expression of KLK14 in prostatic adenocarcinoma is associated with elevated risk of prostate-specific antigen relapse.
Neoplasms
Human kallikrein 14 (KLK14) expression in salivary gland tumors.
Neoplasms
Human kallikrein 14: a new potential biomarker for ovarian and breast cancer.
Neoplasms
Human tissue kallikreins and testicular cancer.
Neoplasms
In vitro evidence that KLK14 regulates the components of the HGF/Met axis, pro-HGF and HGF-activator inhibitor 1A and 1B.
Neoplasms
Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells.
Neoplasms
Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin.
Neoplasms
Kallikrein-related peptidase signaling in colon carcinoma cells: targeting proteinase-activated receptors.
Neoplasms
KLK14 interactions with HAI-1 and HAI-2 serine protease inhibitors: A molecular dynamics and relative free-energy calculations study.
Neoplasms
Mutant recombinant serpins as highly specific inhibitors of human kallikrein 14.
Neoplasms
Non-combinatorial library screening reveals subsite cooperativity and identifies new high efficiency substrates for kallikrein-related peptidase 14.
Neoplasms
Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14.
Neoplasms
Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases.
Neoplasms
Quantitative analysis of human kallikrein gene 14 expression in breast tumours indicates association with poor prognosis.
Neoplasms
Quantitative expression analysis and study of the novel human kallikrein-related peptidase 14 gene (KLK14) in malignant and benign breast tissues.
Neoplasms
Quantitative RT-PCR analysis and immunohistochemical localization of the kallikrein-related peptidases 13 and 14 in lung.
Neoplasms
Steroid hormone regulation and prognostic value of the human kallikrein gene 14 in ovarian cancer.
Neoplasms
The kallikrein 14 gene is down-regulated by androgen receptor signalling and harbours genetic variation that is associated with prostate tumour aggressiveness.
Neoplasms
The molecular function of kallikrein-related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer.
Neoplasms, Germ Cell and Embryonal
Human tissue kallikreins and testicular cancer.
Netherton Syndrome
Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin.
Netherton Syndrome
Toward the first class of suicide inhibitors of kallikreins involved in skin diseases.
Ovarian Neoplasms
Advanced high-grade serous ovarian cancer: inverse association of KLK13 and KLK14 mRNA levels in tumor tissue and patients' prognosis.
Ovarian Neoplasms
Cloning of a new member of the human kallikrein gene family, KLK14, which is down-regulated in different malignancies.
Ovarian Neoplasms
Effects of kallikrein-related peptidase 14 gene inhibition by small interfering RNA in ovarian carcinoma cells.
Ovarian Neoplasms
Human kallikrein 14: a new potential biomarker for ovarian and breast cancer.
Ovarian Neoplasms
Quantitative analysis of human kallikrein gene 14 expression in breast tumours indicates association with poor prognosis.
Ovarian Neoplasms
Steroid hormone regulation and prognostic value of the human kallikrein gene 14 in ovarian cancer.
Prostatic Neoplasms
Differential expression of the human kallikrein gene 14 (KLK14) in normal and cancerous prostatic tissues.
Prostatic Neoplasms
Expression and functional characterization of the cancer-related serine protease, human tissue kallikrein 14.
Prostatic Neoplasms
High expression of KLK14 in prostatic adenocarcinoma is associated with elevated risk of prostate-specific antigen relapse.
Prostatic Neoplasms
In vitro evidence that KLK14 regulates the components of the HGF/Met axis, pro-HGF and HGF-activator inhibitor 1A and 1B.
Prostatic Neoplasms
Kallikrein gene family as biomarkers for recurrent prostate cancer.
Prostatic Neoplasms
Kallikreins are involved in an miRNA network that contributes to prostate cancer progression.
Prostatic Neoplasms
KLK14 interactions with HAI-1 and HAI-2 serine protease inhibitors: A molecular dynamics and relative free-energy calculations study.
Prostatic Neoplasms
MSR1 repeats modulate gene expression and affect risk of breast and prostate cancer.
Prostatic Neoplasms
The kallikrein 14 gene is down-regulated by androgen receptor signalling and harbours genetic variation that is associated with prostate tumour aggressiveness.
Prostatic Neoplasms
The molecular function of kallikrein-related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer.
Psoriasis
Aberrant human tissue kallikrein levels in the stratum corneum and serum of patients with psoriasis: dependence on phenotype, severity and therapy.
Skin Diseases
Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin.
Skin Diseases
Toward the first class of suicide inhibitors of kallikreins involved in skin diseases.
Skin Diseases
Transgenic kallikrein 14 mice display major hair shaft defects associated with desmoglein 3 and 4 degradation, abnormal epidermal differentiation and Il-36 signature.
Testicular Neoplasms
Human tissue kallikreins and testicular cancer.
Testicular Neoplasms
Quantitative analysis of human kallikrein gene 14 expression in breast tumours indicates association with poor prognosis.
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Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (Q9P0G3)
brenda
Hooper, J.D.; Bui, L.T.; Rae, F.K.; Harvey, T.J.; Myers, S.A; Ashworth, L.K.; Clements, J.A.
Identification and characterization of KLK14, novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle
Genomics
73
117-122
2001
Homo sapiens (Q9P0G3), Homo sapiens
brenda
Felber, L.M.; Borgono, C.A.; Cloutier, S.M.; Kuendig, C.; Kishi, T.; Ribeiro Chagas, J.; Jichlinski, P.; Gygi, C.M.; Leisinger, H.J.; Diamandis, E.P.; Deperthes, D.
Enzymatic profiling of human kallikrein 14 using phage-display substrate technology
Biol. Chem.
386
291-298
2005
Homo sapiens
brenda
Fritzsche, F.; Gansukh, T.; Borgono, C.A.; Burkhardt, M.; Pahl, S.; Mayordomo, E.; Winzer, K.J.; Weichert, W.; Denkert, C.; Jung, K.; Stephan, C.; Dietel, M.; Diamandis, E.P.; Dahl, E.; Kristiansen, G.
Expression of human Kallikrein 14 (KLK14) in breast cancer is associated with higher tumour grades and positive nodal status
Br. J. Cancer
94
540-547
2006
Homo sapiens
brenda
Felber, L.M.; Kuendig, C.; Borgono, C.A.; Chagas, J.R.; Tasinato, A.; Jichlinski, P.; Gygi, C.M.; Leisinger, H.J.; Diamandis, E.P.; Deperthes, D.; Cloutier, S.M.
Mutant recombinant serpins as highly specific inhibitors of human kallikrein 14
FEBS J.
273
2505-2514
2006
Homo sapiens
brenda
Stefansson, K.; Brattsand, M.; Ny, A.; Glas, B.; Egelrud, T.
Kallikrein-related peptidase 14 may be a major contributor to trypsin-like proteolytic activity in human stratum corneum
Biol. Chem.
387
761-768
2006
Homo sapiens (Q9P0G3), Homo sapiens
brenda
Emami, N.; Diamandis, E.P.
Human kallikrein-related peptidase 14 (KLK14) is a new activator component of the KLK proteolytic cascade. Possible function in seminal plasma and skin
J. Biol. Chem.
283
3031-3041
2008
Homo sapiens (Q9P0G3), Homo sapiens
brenda
Deraison, C.; Bonnart, C.; Lopez, F.; Besson, C.; Robinson, R.; Jayakumar, A.; Wagberg, F.; Brattsand, M.; Hachem, J.P.; Leonardsson, G.; Hovnanian, A.
LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction
Mol. Biol. Cell
18
3607-3619
2007
Homo sapiens
brenda
Fernando, S.C.; Buck, J.S.; Ashworth, M.D.; Ross, J.W.; Geisert, R.D.; DeSilva, U.
Porcine endometrial and conceptus tissue kallikrein 1, 4, 11, and 14 gene expression
Reproduction
132
939-947
2006
Sus scrofa
brenda
Planque, C.; Blechet, C.; Ayadi-Kaddour, A.; Heuze-Vourch, N.; Dumont, P.; Guyetant, S.; Diamandis, E.P.; El Mezni, F.; Courty, Y.
Quantitative RT-PCR analysis and immunohistochemical localization of the kallikrein-related peptidases 13 and 14 in lung
Biol. Chem.
389
781-786
2008
Homo sapiens (Q9P0G3), Homo sapiens
brenda
Emami, N.; Deperthes, D.; Malm, J.; Diamandis, E.P.
Major role of human KLK14 in seminal clot liquefaction
J. Biol. Chem.
283
19561-19569
2008
Homo sapiens (Q9P0G3), Homo sapiens
brenda
Rabien, A.; Fritzsche, F.; Jung, M.; Diamandis, E.P.; Loening, S.A.; Dietel, M.; Jung, K.; Stephan, C.; Kristiansen, G.
High expression of KLK14 in prostatic adenocarcinoma is associated with elevated risk of prostate-specific antigen relapse
Tumour Biol.
29
1-8
2008
Homo sapiens
brenda
Emami, N.; Scorilas, A.; Soosaipillai, A.; Earle, T.; Mullen, B.; Diamandis, E.P.
Association between kallikrein-related peptidases (KLKs) and macroscopic indicators of semen analysis: their relation to sperm motility
Biol. Chem.
390
921-929
2009
Homo sapiens
brenda
Angelopoulou, K.; Prassas, I.; Yousef, G.M.
The canine kallikrein-related peptidase 14: structural characterization, alternative splicing and differential expression in mammary cancer
Gene
446
68-74
2009
Canis lupus familiaris (C7T1J3), Canis lupus familiaris
brenda
Hashem, N.N.; Mara, T.W.; Mohamed, M.; Zhang, I.; Fung, K.; Kwan, K.F.; Daley, T.D.; Diamandis, E.P.; Darling, M.R.
Human kallikrein 14 (KLK14) expression in salivary gland tumors
Int. J. Biol. Markers
25
32-37
2010
Homo sapiens
brenda
Meyer-Hoffert, U.; Wu, Z.; Kantyka, T.; Fischer, J.; Latendorf, T.; Hansmann, B.; Bartels, J.; He, Y.; Glaeser, R.; Schroeder, J.M.
Isolation of Spink6 in human skin: a selective inhibitor of kallikrein-related peptidases
J. Biol. Chem.
285
32174-32181
2010
Homo sapiens
brenda
Gratio, V.; Loriot, C.; Virca, G.D.; Oikonomopoulou, K.; Walker, F.; Diamandis, E.P.; Hollenberg, M.D.; Darmoul, D.
Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells
Am. J. Pathol.
179
2625-2636
2011
Homo sapiens
brenda
de Veer, S.J.; Swedberg, J.E.; Parker, E.A.; Harris, J.M.
Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14
Biol. Chem.
393
331-341
2012
Homo sapiens (Q9P0G3)
brenda
Ramachandran, R.; Eissa, A.; Mihara, K.; Oikonomopoulou, K.; Saifeddine, M.; Renaux, B.; Diamandis, E.; Hollenberg, M.D.
Proteinase-activated receptors (PARs): differential signalling by kallikrein-related peptidases KLK8 and KLK14
Biol. Chem.
393
421-427
2012
Homo sapiens (Q9P0G3), Homo sapiens
brenda
Reid, J.C.; Bennett, N.C.; Stephens, C.R.; Carroll, M.L.; Magdolen, V.; Clements, J.A.; Hooper, J.D.
In vitro evidence that KLK14 regulates the components of the HGF/Met axis, pro-HGF and HGF-activator inhibitor 1A and 1B
Biol. Chem.
397
1299-1305
2016
Homo sapiens (Q9P0G3)
brenda
Ulbricht, D.; Tindall, C.A.; Oertwig, K.; Hanke, S.; Straeter, N.; Heiker, J.T.
Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin
Biol. Chem.
399
1079-1084
2018
Homo sapiens (Q9P0G3)
brenda
Kontos, C.K.; Adamopoulos, P.G.; Papageorgiou, S.G.; Pappa, V.; Scorilas, A.
mRNA overexpression of kallikrein-related peptidase 14 (KLK14) is an independent predictor of poor overall survival in chronic lymphocytic leukemia patients
Clin. Chem. Lab. Med.
54
315-324
2016
Homo sapiens (Q9P0G3), Homo sapiens
brenda