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Information on EC 2.7.11.19 - phosphorylase kinase

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IUBMB Comments
Requires Ca2+ and calmodulin for activity. The enzyme phosphorylates a specific serine residue in each of the subunits of the dimeric phosphorylase b. For muscle phosphorylase but not liver phosphorylase, this is accompanied by a further dimerization to form a tetrameric phosphorylase. The enzyme couples muscle contraction with energy production via glycogenolysis---glycolysis by catalysing the Ca2+-dependent phosphorylation and activation of glycogen phosphorylase b . The gamma subunit of the tetrameric enzyme is the catalytic subunit.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
phosphorylase b kinase, glycogen phosphorylase kinase, phkg1, dphk-gamma, psk-c3, glycogen phosphorylase b kinase, kpi-2 kinase, dephosphophosphorylase kinase, skm phk, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 ATP + phosphorylase b = 2 ADP + phosphorylase a
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