show all | hide all No of entries

Information on EC - cGMP-dependent protein kinase

for references in articles please use BRENDA:EC2.7.11.12
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
CGMP is required to activate this enzyme. The enzyme occurs as a dimer in higher eukaryotes. The C-terminal region of each polypeptide chain contains the catalytic domain that includes the ATP and protein substrate binding sites. This domain catalyses the phosphorylation by ATP to specific serine or threonine residues in protein substrates . The enzyme also has two allosteric cGMP-binding sites (sites A and B). Binding of cGMP causes a conformational change that is associated with activation of the kinase .
Specify your search results
Select one or more organisms in this record: ?
Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
Reaction Schemes
CGK, CGK 1 alpha, CGK 1 beta, cGK I, cGK II, cGK-I, cGK-II, cGKI, cGKI alpha, cGKI beta, more
ATP + a protein = ADP + a phosphoprotein
show the reaction diagram