Any feedback?
Information on EC 3.4.13.18 - cytosol nonspecific dipeptidase
for references in articles please use BRENDA:EC3.4.13.18Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
3.4.13.18 cytosol nonspecific dipeptidaseSpecify your search results
Word Map
- 3.4.13.18
- prolidase
-
3.4.13.11
-
carnosinase
-
glycosyl-phosphatidylinositol
- pro-leu
- iminopeptidase
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids
Synonyms
prolinase, cndp2, glycyl-l-leucine dipeptidase, cpgl-b, non-specific dipeptidase, glycyl-glycine dipeptidase, glycylleucine dipeptidase, glycyl-l-leucine hydrolase, iminodipeptidase, dpp8-v3, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
CNDP2
diglycinase
-
-
-
-
dipeptidase, glycylglycine
-
-
-
-
EC 3.4.13.1
-
-
formerly
-
EC 3.4.13.11
-
-
formerly
-
EC 3.4.13.13
-
-
formerly, part transferred
-
EC 3.4.13.15
-
-
formerly
-
EC 3.4.13.2
EC 3.4.13.3
-
-
formerly, part transferred
-
EC 3.4.13.8
EC 3.4.3.1
-
-
formerly
-
EC 3.4.3.2
-
-
formerly
-
EC 3.4.3.3
-
-
formerly, part transferred
-
EC 3.4.3.6
-
-
formerly
-
Gly-Leu hydrolase
-
-
-
-
glycyl-glycine dipeptidase
-
-
-
-
glycyl-L-leucine dipeptidase
glycyl-L-leucine hydrolase
-
-
-
-
glycyl-L-leucine peptidase
-
-
-
-
glycyl-leucine dipeptidase
-
-
-
-
glycylleucine dipeptidase
-
-
-
-
glycylleucine dipeptide hydrolase
-
-
-
-
glycylleucine hydrolase
-
-
-
-
glycylleucine peptidase
-
-
-
-
human cytosolic non-specific dipeptidase
-
prolinase and carnosinase activity reside in the same enzyme
iminodipeptidase
-
-
-
-
L-amino-acyl-L-amino-acid hydrolase
-
-
-
-
L-prolylglycine dipeptidase
-
-
-
-
N2-beta-alanylarginine dipeptidase
-
-
-
-
non-specific dipeptidase
-
-
-
-
PepD
Peptidase A
-
-
-
-
Pro-X dipeptidase
-
-
-
-
Pro-Xaa dipeptidase
-
-
-
-
prolinase
prolyl dipeptidase
EC 3.4.13.2
-
-
formerly
-
EC 3.4.13.8
-
-
formerly
-
glycyl-L-leucine dipeptidase
-
-
-
-
prolinase
-
-
-
-
prolyl dipeptidase
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of peptide bond
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
9025-31-4
-
9032-23-9
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-Ala-4-methylcoumarin 7-amide + H2O
L-Ala + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Ala-4-methylcoumarin 7-amide + H2O
L-Ala + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Lys-4-methylcoumarin 7-amide + H2O
L-Lys + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Lys-4-methylcoumarin 7-amide + H2O
L-Lys + 7-amino-4-methylcoumarin
-
-
-
-
?
additional information
?
-
-
hydrolyzes dipeptides and dipeptidyl amides with L-proline or hydroxy-L-proline at the N-terminus
-
-
?
additional information
?
-
-
the tumor enzyme has the highest maximal velocities with substrates containing uncharged bulky C-terminal and small, uncharged N-terminal side chains, the bacterial enzyme hydrolyzes most rapidly substrates with long or flat N-terminal R-groups and small or positively charged C-terminal groups
-
-
?
additional information
?
-
-
DPP8-v3 may play a key role in the immunoregulation of testes and accordingly may influence spermatogenesis and male fertility
-
-
?
additional information
?
-
-
the enzyme catalyzes cleavage at the carboxyl side of the proline residue at the penultimate position
-
-
?
additional information
?
-
CNDP2 catalyzes the formation of N-lactoyl-amino acids. The plasma levels of of N-lactoyl-amino acids strongly correlate with plasma levels of lactate and amino acids
-
-
?
additional information
?
-
-
peptides with small NH2-terminal and bulky nonpolar COOH-terminal R groups are preferred
-
-
?
additional information
?
-
-
the tumor enzyme has the highest maximal velocities with substrates containing uncharged bulky C-terminal and small, uncharged N-terminal side chains, the bacterial enzyme hydrolyzes most rapidly substrates with long or flat N-terminal R-groups and small or positively charged C-terminal groups
-
-
?
additional information
?
-
-
not: some of the arginine- and aspartic acid-containing dipeptides
-
-
?
additional information
?
-
-
no or very poor substrate: Leu-4-methylcoumarin 7-amide, Met-4-methylcoumarin 7-amide, Phe-4-methylcoumarin 7-amide, L-Lys-L-Ala-4-methylcoumarin 7-amide
-
-
?
additional information
?
-
-
no or very poor substrate: Leu-4-methylcoumarin 7-amide, Met-4-methylcoumarin 7-amide, Phe-4-methylcoumarin 7-amide, L-Lys-L-Ala-4-methylcoumarin 7-amide
-
-
?
additional information
?