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Information on EC - cathepsin F

for references in articles please use BRENDA:EC3.4.22.41
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
       cathepsin F
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The enzyme appears in viruses and cellular organisms
cat F, CatF, cathepsin f, cathepsin F-1, CATSF, CF-1, CF-11, CF-4, CF-6, cf1, more
The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (kcat/Km) comparable to that of cathepsin L
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Cathepsin F is a lysosomal cysteine endopeptidase of family C1, papain family, most activite at pH 5.9. The enzyme is unstable at neutral pH values and is inhibited by compound E-64. Cathepsin F is expressed in most tissues of human, mouse and rat. Human gene locus: 11q13.1-13.3; endopeptidase
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