Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1S,2R,5S)-5-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-2-(2,4,5-trifluorophenyl)cyclohexanamine | - |
Homo sapiens | |
(2R)-1-[8-(trifluoromethyl)bis[1,2,4]triazolo[4,3-a:3',4'-c]pyrazin-3-yl]-3-(2,4,5-trifluorophenyl)propan-2-amine | - |
Homo sapiens | |
(2R)-1-[9-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4',3':1,2]pyrido[3,4-d]pyrimidin-3-yl]-3-(2,4,5-trifluorophenyl)propan-2-amine | - |
Homo sapiens | |
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine | sitagliptin | Homo sapiens | |
(2R)-4-[(2R)-2-benzylpiperazin-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine | - |
Homo sapiens | |
(2R)-4-[1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine | - |
Homo sapiens | |
(2R)-4-[4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine | - |
Homo sapiens | |
(2R)-4-[8-(4-fluorobenzyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine | - |
Homo sapiens | |
(2R)-4-[8-(4-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine | - |
Homo sapiens | |
(2R)-4-[8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine | - |
Homo sapiens | |
(2R)-4-[8-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine | - |
Homo sapiens | |
(2R,3S,5R)-5-[2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-amine | - |
Homo sapiens | |
(2S)-1-([(2S,4S)-4-[(3-chloro-4-cyanophenyl)amino]pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S)-1-[(2S,3S)-2-amino-3-methylpentanoyl]pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S)-1-[[(1R,3S,5R,7R)-tricyclo[3.3.1.13,7]dec-2-ylamino]acetyl]pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S)-1-[[(1R,5R)-tricyclo[3.3.1.13,7]dec-2-ylamino]acetyl]pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S)-1-[[(2S,4S)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S)-1-[[(3R,4R)-4-amino-1-(4-cyano-3-methylbenzyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(2S)-2-[4-[([1-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid | - |
Homo sapiens | |
(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine | - |
Homo sapiens | |
(2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)butanamide | - |
Homo sapiens | |
(2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(trans-4-[1,2,4]triazolo[1,5-a]pyridin-6-ylcyclohexyl)butanamide | - |
Homo sapiens | |
(2S,3S)-3-methyl-1-oxo-1-pyrrolidin-1-ylpentan-2-amine | - |
Homo sapiens | |
(2S,3S)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine | - |
Homo sapiens | |
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-cyclopropyl-3-methyl-1,4-diazepan-2-one | - |
Homo sapiens | |
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one | - |
Homo sapiens | |
(3R,4R)-1-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine | - |
Homo sapiens | |
(3R,4S)-1-[4-[3-(methylsulfonyl)phenyl]-1,3,5-triazin-2-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine | - |
Homo sapiens | |
(3R,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6-dimethyl-1,4-diazepan-2-one | - |
Homo sapiens | |
(3S)-1-[6-[(3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyrimidin-4-yl]pyrrolidin-3-ol | - |
Homo sapiens | |
(4R,5R)-5-amino-1-[2-[3-(methylsulfonyl)phenyl]ethyl]-4-(2,4,5-trifluorophenyl)piperidin-2-one | - |
Homo sapiens | |
(7R,8R)-2-methyl-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydropyrido[3',2':4,5]imidazo[1,2-a]pyridin-8-amine | - |
Homo sapiens | |
1-(3-methyl-1,2,4-thiadiazol-5-yl)-4-[[(2S,3S,5S)-2-methyl-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]carbonyl]piperazine | - |
Homo sapiens | |
1-[(3R)-3-amino-4-phenylbutanoyl]-N-[5-chloro-2-[2-(cyclopropylamino)-2-oxoethoxy]benzyl]-L-prolinamide | - |
Homo sapiens | |
1-[(3S,4S)-4-amino-1-[4-(3,3-difluoropyrrolidin-1-yl)-1,3,5-triazin-2-yl]pyrrolidin-3-yl]-4,4-difluoropiperidin-2-one | - |
Homo sapiens | |
1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-4-[4-(trifluoromethyl)pyridin-2-yl]piperazine | - |
Homo sapiens | |
2-(3-but-2-yn-1-yl-4-oxo-2-piperazin-1-yl-3,4-dihydro-5H-imidazo[4,5-d]pyridazin-5-yl)benzonitrile | - |
Homo sapiens | |
2-([2-[(1R,3S)-3-aminocyclohexyl]-5-benzyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]pyridin-3-yl]methyl)benzonitrile | - |
Homo sapiens | |
2-([2-[(3R)-3-aminopiperidin-1-yl]-6-fluoro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile | - |
Homo sapiens | |
2-[(7-but-2-yn-1-yl-2-methoxy-6-oxo-8-piperazin-1-yl-6,7-dihydro-1H-purin-1-yl)methyl]benzonitrile | - |
Homo sapiens | |
2-[[2-(3-aminopiperidin-1-yl)-5,6-dimethyl-4,7-dioxo-4,5,6,7-tetrahydro-1H-imidazo[4,5-d]pyridazin-1-yl]methyl]benzonitrile | - |
Homo sapiens | |
2-[[2-(3-aminopiperidin-1-yl)-5-methyl-4,6-dioxo-5,6-dihydropyrrolo[3,4-d]imidazol-1(4H)-yl]methyl]benzonitrile | - |
Homo sapiens | |
3-(aminomethyl)-4-(2,4-dichlorophenyl)-7,8-dimethoxy-5H-indeno[1,2-b]pyridin-2-amine | - |
Homo sapiens | |
3-but-2-yn-1-yl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | - |
Homo sapiens | |
3-butyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine | - |
Homo sapiens | |
3-[6-[(3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyrimidin-4-yl]phenyl methanesulfonate | - |
Homo sapiens | |
4-([1-[(2-oxo-2-thiophen-3-ylethyl)amino]cyclopentyl]methoxy)benzamide | - |
Homo sapiens | |
4-[(3R)-3-[[2-(4-fluorophenyl)-2-oxoethyl]amino]butyl]benzamide | - |
Homo sapiens | |
4-[[(2R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-2-yl]methoxy]-3-(1-methylethyl)benzoic acid | - |
Homo sapiens | |
5-(aminomethyl)-6-(1,3-benzodioxol-5-yl)-2-phenylpyrimidin-4-amine | - |
Homo sapiens | |
5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,5-dimethoxyphenyl)pyrimidin-4-amine | - |
Homo sapiens | |
5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-phenylpyrimidin-4-amine | - |
Homo sapiens | |
5-(aminomethyl)-6-(2,4-dichlorophenyl)-N2-(2-methoxyethyl)-N2-methylpyrimidine-2,4-diamine | - |
Homo sapiens | |
6-(aminomethyl)-5-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine | - |
Homo sapiens | |
6-{[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)ethyl]amino}pyridine-3-carbonitrile | - |
Homo sapiens | |
7-benzyl-3-methyl-8-piperazin-1-yl-3,7-dihydro-1H-purine-2,6-dione | - |
Homo sapiens | |
7-[(2E)-but-2-en-1-yl]-8-(3,3-dimethylpiperazin-1-yl)-3-methyl-1-(2-oxo-2-phenylethyl)-3,7-dihydro-1H-purine-2,6-dione | - |
Homo sapiens | |
7-[(3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]-2H-pyrimido[1,2-b]pyridazin-2-one | - |
Homo sapiens | |
8-[(3R)-3-aminopiperidin-1-yl]-3-methyl-7-(3-methylbut-2-en-1-yl)-1-(2-oxo-2-phenylethyl)-3,7-dihydro-1H-purine-2,6-dione | - |
Homo sapiens | |
ABT-279 | - |
Homo sapiens | |
ABT-341 | - |
Homo sapiens | |
denagliptin | - |
Homo sapiens | |
N-([(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]methyl)-3-[(4-methyl-1,3-thiazol-2-yl)sulfamoyl]benzamide | - |
Homo sapiens | |
N-[3-[(2-[4-[(2S)-2-amino-3-phenylpropyl]-3-benzylpiperazin-1-yl]ethyl)amino]phenyl]methanesulfonamide | - |
Homo sapiens | |
N-[[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]methyl]-1,3-thiazole-4-carboxamide | - |
Homo sapiens | |
P32/98 | - |
Homo sapiens | |
saxagliptin | - |
Homo sapiens | |
sitagliptin | - |
Homo sapiens | |
vildagliptin | LAF-237 | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
100000 | - |
2 * 100000, DPP-IV is catalytically active as a dimer | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
bradykinin + H2O | Homo sapiens | - |
? | - |
? | |
gastrin-releasing peptide + H2O | Homo sapiens | - |
? | - |
? | |
glucagon-like peptide-1 (7-36)-amide + H2O | Homo sapiens | - |
? | - |
? | |
glucose-dependent insulinotropic peptide + H2O | Homo sapiens | - |
? | - |
? | |
growth hormone-releasing hormone + H2O | Homo sapiens | - |
? | - |
? | |
neuropeptide Y + H2O | Homo sapiens | - |
? | - |
? | |
peptide YY + H2O | Homo sapiens | - |
? | - |
? | |
RANTES protein + H2O | Homo sapiens | - |
? | - |
? | |
Substance P + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Caco-2 cell | - |
Homo sapiens | - |
endothelial cell | - |
Homo sapiens | - |
intestine | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
lymphocyte | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
prostate gland | - |
Homo sapiens | - |
skin | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
gastrin-releasing peptide + H2O | - |
Homo sapiens | ? | - |
? | |
glucagon-like peptide-1 (7-36)-amide + H2O | - |
Homo sapiens | ? | - |
? | |
glucose-dependent insulinotropic peptide + H2O | - |
Homo sapiens | ? | - |
? | |
growth hormone-releasing hormone + H2O | - |
Homo sapiens | ? | - |
? | |
neuropeptide Y + H2O | - |
Homo sapiens | ? | - |
? | |
peptide YY + H2O | - |
Homo sapiens | ? | - |
? | |
RANTES protein + H2O | - |
Homo sapiens | ? | - |
? | |
Substance P + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 100000, DPP-IV is catalytically active as a dimer | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ADA-binding protein | - |
Homo sapiens |
adenosine deaminase-binding protein | - |
Homo sapiens |
CD26 | - |
Homo sapiens |
dipeptidyl peptidase-IV | - |
Homo sapiens |
DPP-IV | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000013 | - |
ABT-341 | - |
Homo sapiens | |
0.0000017 | - |
N-([(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]methyl)-3-[(4-methyl-1,3-thiazol-2-yl)sulfamoyl]benzamide | - |
Homo sapiens | |
0.000002 | - |
2-[[2-(3-aminopiperidin-1-yl)-5-methyl-4,6-dioxo-5,6-dihydropyrrolo[3,4-d]imidazol-1(4H)-yl]methyl]benzonitrile | - |
Homo sapiens | |
0.0000021 | - |
(3R,4S)-1-[4-[3-(methylsulfonyl)phenyl]-1,3,5-triazin-2-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine | - |
Homo sapiens | |
0.0000022 | - |
(2S)-1-[(2S,3S)-2-amino-3-methylpentanoyl]pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
0.0000023 | - |
(3S)-1-[6-[(3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyrimidin-4-yl]pyrrolidin-3-ol | - |
Homo sapiens | |
0.0000031 | - |
4-[[(2R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-2-yl]methoxy]-3-(1-methylethyl)benzoic acid | - |
Homo sapiens | |
0.000004 | - |
(4R,5R)-5-amino-1-[2-[3-(methylsulfonyl)phenyl]ethyl]-4-(2,4,5-trifluorophenyl)piperidin-2-one | - |
Homo sapiens | |
0.000004 | - |
3-[6-[(3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyrimidin-4-yl]phenyl methanesulfonate | - |
Homo sapiens | |
0.000005 | - |
N-[[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]methyl]-1,3-thiazole-4-carboxamide | - |
Homo sapiens | |
0.000012 | - |
2-[[2-(3-aminopiperidin-1-yl)-5,6-dimethyl-4,7-dioxo-4,5,6,7-tetrahydro-1H-imidazo[4,5-d]pyridazin-1-yl]methyl]benzonitrile | - |
Homo sapiens | |
0.000126 | - |
P32/98 | - |
Homo sapiens | |
0.00041 | - |
(2S,3S)-3-methyl-1-oxo-1-pyrrolidin-1-ylpentan-2-amine | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000001 | - |
- |
Homo sapiens | 5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,5-dimethoxyphenyl)pyrimidin-4-amine | |
0.00000013 | - |
- |
Homo sapiens | (2S)-1-([(2S,4S)-4-[(3-chloro-4-cyanophenyl)amino]pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile | |
0.00000018 | - |
- |
Homo sapiens | (2R)-4-[8-(4-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine | |
0.00000048 | - |
- |
Homo sapiens | (2S)-2-[4-[([1-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid | |
0.0000006 | - |
- |
Homo sapiens | saxagliptin | |
0.000001 | - |
- |
Homo sapiens | ABT-279 | |
0.000001 | - |
- |
Homo sapiens | Bl-1356 | |
0.000001 | - |
- |
Homo sapiens | 7-[(2E)-but-2-en-1-yl]-8-(3,3-dimethylpiperazin-1-yl)-3-methyl-1-(2-oxo-2-phenylethyl)-3,7-dihydro-1H-purine-2,6-dione | |
0.0000012 | - |
- |
Homo sapiens | 7-[(3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]-2H-pyrimido[1,2-b]pyridazin-2-one | |
0.0000013 | - |
- |
Homo sapiens | (2S)-1-[[(3R,4R)-4-amino-1-(4-cyano-3-methylbenzyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile | |
0.0000015 | - |
- |
Homo sapiens | 1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-4-[4-(trifluoromethyl)pyridin-2-yl]piperazine | |
0.0000017 | - |
- |
Homo sapiens | (2S)-1-[[(2S,4S)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile | |
0.0000022 | - |
- |
Homo sapiens | 2-[(7-but-2-yn-1-yl-2-methoxy-6-oxo-8-piperazin-1-yl-6,7-dihydro-1H-purin-1-yl)methyl]benzonitrile | |
0.0000026 | - |
- |
Homo sapiens | (3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one | |
0.0000027 | - |
enzyme isolated from blood plasma | Homo sapiens | vildagliptin | |
0.000003 | - |
- |
Homo sapiens | 5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-phenylpyrimidin-4-amine | |
0.000003 | - |
- |
Homo sapiens | (2S)-1-[[(1R,3S,5R,7R)-tricyclo[3.3.1.13,7]dec-2-ylamino]acetyl]pyrrolidine-2-carbonitrile | |
0.0000035 | - |
enzyme isolated from Caco-2 cells | Homo sapiens | vildagliptin | |
0.000004 | - |
- |
Homo sapiens | 2-([2-[(3R)-3-aminopiperidin-1-yl]-6-fluoro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile | |
0.000004 | - |
- |
Homo sapiens | (2R)-4-[8-(4-fluorobenzyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine | |
0.0000043 | - |
- |
Homo sapiens | (2R)-4-[8-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine | |
0.0000046 | - |
- |
Homo sapiens | (2S,3S)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine | |
0.0000048 | - |
- |
Homo sapiens | (2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(trans-4-[1,2,4]triazolo[1,5-a]pyridin-6-ylcyclohexyl)butanamide | |
0.000005 | - |
- |
Homo sapiens | 4-([1-[(2-oxo-2-thiophen-3-ylethyl)amino]cyclopentyl]methoxy)benzamide | |
0.0000058 | - |
- |
Homo sapiens | (2R)-4-[4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine | |
0.000006 | - |
- |
Homo sapiens | (3R,4R)-1-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine | |
0.000006 | - |
- |
Homo sapiens | 8-[(3R)-3-aminopiperidin-1-yl]-3-methyl-7-(3-methylbut-2-en-1-yl)-1-(2-oxo-2-phenylethyl)-3,7-dihydro-1H-purine-2,6-dione | |
0.000007 | - |
- |
Homo sapiens | 3-(aminomethyl)-4-(2,4-dichlorophenyl)-7,8-dimethoxy-5H-indeno[1,2-b]pyridin-2-amine | |
0.000007 | - |
enzyme isolated from blood plasma | Homo sapiens | 6-{[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)ethyl]amino}pyridine-3-carbonitrile | |
0.0000073 | - |
- |
Homo sapiens | 2-(3-but-2-yn-1-yl-4-oxo-2-piperazin-1-yl-3,4-dihydro-5H-imidazo[4,5-d]pyridazin-5-yl)benzonitrile | |
0.000008 | - |
- |
Homo sapiens | (3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-cyclopropyl-3-methyl-1,4-diazepan-2-one | |
0.0000088 | - |
- |
Homo sapiens | (2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)butanamide | |
0.000009 | - |
- |
Homo sapiens | 5-(aminomethyl)-6-(2,4-dichlorophenyl)-N2-(2-methoxyethyl)-N2-methylpyrimidine-2,4-diamine | |
0.0000097 | - |
- |
Homo sapiens | (3R,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6-dimethyl-1,4-diazepan-2-one | |
0.000013 | - |
- |
Homo sapiens | (2S)-1-[[(1R,5R)-tricyclo[3.3.1.13,7]dec-2-ylamino]acetyl]pyrrolidine-2-carbonitrile | |
0.000014 | - |
- |
Homo sapiens | 1-(3-methyl-1,2,4-thiadiazol-5-yl)-4-[[(2S,3S,5S)-2-methyl-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]carbonyl]piperazine | |
0.000018 | - |
- |
Homo sapiens | sitagliptin | |
0.000018 | - |
- |
Homo sapiens | (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine | |
0.000019 | - |
- |
Homo sapiens | (2R)-4-[(2R)-2-benzylpiperazin-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine | |
0.000021 | - |
- |
Homo sapiens | (1S,2R,5S)-5-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-2-(2,4,5-trifluorophenyl)cyclohexanamine | |
0.000022 | - |
- |
Homo sapiens | denagliptin | |
0.000022 | - |
enzyme isolated from Caco-2 cells | Homo sapiens | 6-{[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)ethyl]amino}pyridine-3-carbonitrile | |
0.000024 | - |
- |
Homo sapiens | 1-[(3S,4S)-4-amino-1-[4-(3,3-difluoropyrrolidin-1-yl)-1,3,5-triazin-2-yl]pyrrolidin-3-yl]-4,4-difluoropiperidin-2-one | |
0.000025 | - |
- |
Homo sapiens | (2R)-4-[8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine | |
0.000045 | - |
- |
Homo sapiens | (2R)-4-[1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine | |
0.000064 | - |
- |
Homo sapiens | (2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine | |
0.000084 | - |
- |
Homo sapiens | 4-[(3R)-3-[[2-(4-fluorophenyl)-2-oxoethyl]amino]butyl]benzamide | |
0.0001 | - |
- |
Homo sapiens | 3-but-2-yn-1-yl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one | |
0.00042 | - |
- |
Homo sapiens | P32/98 | |
0.00064 | - |
- |
Homo sapiens | 3-butyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine | |
0.0019 | - |
- |
Homo sapiens | 1-[(3R)-3-amino-4-phenylbutanoyl]-N-[5-chloro-2-[2-(cyclopropylamino)-2-oxoethoxy]benzyl]-L-prolinamide | |
0.0039 | - |
- |
Homo sapiens | 7-benzyl-3-methyl-8-piperazin-1-yl-3,7-dihydro-1H-purine-2,6-dione | |
0.01 | - |
- |
Homo sapiens | 5-(aminomethyl)-6-(1,3-benzodioxol-5-yl)-2-phenylpyrimidin-4-amine | |
0.011 | - |
- |
Homo sapiens | N-[3-[(2-[4-[(2S)-2-amino-3-phenylpropyl]-3-benzylpiperazin-1-yl]ethyl)amino]phenyl]methanesulfonamide |