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Information on EC 2.4.1.69 - type 1 galactoside alpha-(1,2)-fucosyltransferase
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2.4.1.69 type 1 galactoside alpha-(1,2)-fucosyltransferaseIUBMB Comments
The enzyme acts on a glycoconjugates where R (see reaction) is a glycoprotein or glycosphingolipid. The recognized moiety of the substrate is known as a type 1 histo-blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen. In humans the main enzyme performing this reaction is encoded by the FUT2 gene (also known as the Secretor gene), which is also able to act on type 2 substrates (see EC 2.4.1.344). The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates.
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Word Map
- 2.4.1.69
-
fucosylation
- oligosaccharide
-
sialylated
- glycans
- glycosyltransferases
- epitope
- lectin
-
sialyltransferase
- glycolipids
- selectins
- glycoconjugates
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histo-blood
-
n-acetylglucosaminyltransferase
-
fucts
-
e-selectin
-
nonsecretors
-
sialyl-lewis
- asialofetuin
- alpha-l-fucosidase
- xyloglucan
-
lewisa
-
hyperacute
-
fucosidase
- 2'-fucosyllactose
- n-acetyllactosamine
-
h-type
-
bombay
- lactosamine
-
xenoreactive
- psgl-1
-
fucose-containing
- fuct-vii
- analysis
-
difucosylated
- gnt-iii
-
hbgas
-
alpha1-6
- medicine
- noroviruses
-
1-3glcnac
-
xenoantigens
-
xylosyltransferase
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glycomic
- lacnac
- synthesis
- neuac
- alpha-gal
-
alpha1,3-galactosyltransferase
- tamarind
- lacto-n-biose
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
fucosyltransferase, alpha1,2-fucosyltransferase, alpha(1,2)fucosyltransferase, fucosyltransferase 2, alpha1,2-ft, alpha(1,2)-fucosyltransferase, alpha-2-l-fucosyltransferase, fucosyltransferase 1, alpha-1,2-fucosyltransferase, alpha1,2ft, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
alpha-(1->2)-L-fucosyltransferase
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-
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alpha-1,2-fucosyltransferase
alpha-2-fucosyltransferase
alpha-2-L-fucosyltransferase
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alpha-L-fucosyltransferase
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alpha1,2-fucosyltransferase
alpha1,2-FucT
alpha1,2FT
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alpha1,2fucosyltransferase
alpha1-2FucT
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alpha1->2-fucosyltransferase
alpha1->2-FucT
alpha2-fucosyltransferase
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dual function as beta3-galactosyltransferase/alpha2-fucosyltransferase
alpha2FT
beta-galactoside alpha1-2fucosyltransferase
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blood group H alpha-2-fucosyltransferase
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blood-group substance H-dependent fucosyltransferase
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CE2FT-2
EC 2.4.1.89
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formerly
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fucosyltransferase 2
fucosyltransferase, guanosine diphosphofucose-galactoside 2-L-
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fucosyltransferase, guanosine diphosphofucose-glycoprotein 2-alpha-
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fucosyltransferase, guanosine diphosphofucose-lactose
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FucT
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FUT1
FUT2
futC
galactoside 2-alpha-L-fucosyltransferase
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GDP fucose-lactose fucosyltransferase
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GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase
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GDP-fucose:GM1 alpha1-2fucosyltransferase
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GDP-L-fucose:beta-D-galactosyl-R-alpha-L-fucosyltransferase
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GDP-L-fucose:lactose fucosyltransferase
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GDPFuc:beta-D-galactoside alpha1,2-fucosyltransferase
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guanosine diphospho-L-fucose-lactose fucosyltransferase
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guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase
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-
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guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase
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-
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guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase
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H gene-encoded beta-galactoside alpha1->2 fucosyltransferase
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H-gene-encoded beta-galactoside alpha1-2fucosyltransferase
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Se gene-encoded beta-galactoside alpha1->2 fucosyltransferase
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Sec1
secretor-type beta-galactoside alpha1-2fucosyltransferase
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WbgL
WbiQ
WbsJ
wbwK
alpha-2-fucosyltransferase
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CE2FT-2
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gene encoding an alpha1,2fucosyltransferase without activity towards Galbeta-O-p-nitrophenol or Galalpha-O-p-nitrophenol
WbsJ
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gene encoding an alpha1,2fucosyltransferase in Escherichia coli with a broad substrate specificity
WbsJ
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gene encoding an alpha1,2fucosyltransferase in Escherichia coli with a broad substrate specificity
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wbwK
Q5JBG3
gene encoding an alpha1,2fucosyltransferase in Escherichia coli which is only active with substrates containing the Galbeta1,3GalNAcalpha-structure (T-antigen) to form H-type 3 blood group antigen (Fucalpha1,2Galbeta1,3GalNAcalpha-OR) but not with Galbeta-OMe
wbwK
Q5JBG3
gene encoding an alpha1,2fucosyltransferase in Escherichia coli which is only active with substrates containing the Galbeta1,3GalNAcalpha-structure (T-antigen) to form H-type 3 blood group antigen (Fucalpha1,2Galbeta1,3GalNAcalpha-OR) but not with Galbeta-OMe
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R
either a rapid equilibrium random kinetic mechanism or a steady state ordered mechanism with GDP-L-fucose binding first
-
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hexosyl group transfer
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-
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PATHWAY SOURCE
PATHWAYS
KEGG
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SYSTEMATIC NAME
IUBMB Comments
GDP-beta-L-fucose:beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R alpha-(1,2)-L-fucosyltransferase (configuration-inverting)
The enzyme acts on a glycoconjugates where R (see reaction) is a glycoprotein or glycosphingolipid. The recognized moiety of the substrate is known as a type 1 histo-blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen. In humans the main enzyme performing this reaction is encoded by the FUT2 gene (also known as the Secretor gene), which is also able to act on type 2 substrates (see EC 2.4.1.344). The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates.
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CAS REGISTRY NUMBER
COMMENTARY
56093-23-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
GDP-beta-L-fucose + 2-nitrophenyl beta-D-galactopyranoside
GDP + 2-nitrophenyl alpha-L-fucosyl-(1->2)-beta-D-galactopyranoside
-
-
-
-
?
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine
GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine
GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine
GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine
GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-galactosamine
GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-galactosamine
residues of H type 3 epitopes, reaction of EC 2.4.1.69
-
-
?
GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
residues of H type 2 epitopes
-
-
?
GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine
GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine
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i.e. N-acetyllactosamine, reaction of EC 2.4.1.344
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-
?
GDP-beta-L-fucose + D-Gal-beta-(1,2)-D-Glc-beta-O-methyl
GDP + L-Fuc-alpha-(1,2)-D-Gal-beta-(1,2)-D-Glc-beta-O-methyl
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-
-
-
?
GDP-beta-L-fucose + D-Gal-beta-(1,4)-D-Glc-beta-O-methyl
GDP + L-Fuc-alpha-(1,2)-D-Gal-beta-(1,4)-D-Glc-beta-O-methyl
-
-
-
-
?
GDP-beta-L-fucose + D-Gal-beta-(1,6)-D-Glc-beta-O-methyl
GDP + L-Fuc-alpha-(1,2)-D-Gal-beta-(1,6)-D-Glc-beta-O-methyl
-
-
-
-
?
GDP-beta-L-fucose + D-Gal-beta-(1->3)-D-Glcbeta-O-methyl
GDP + L-Fuc-alpha-(1->2)-D-Gal-beta-(1->3)-D-Glc-beta-O-methyl
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-
-
-
?
GDP-beta-L-fucose + Gal(beta1-3)GlcNAc
?
28% activity compared to D-lactose
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-
?
GDP-beta-L-fucose + Gal(beta1-4)GlcNAc
?
85% activity compared to D-lactose
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-
?
GDP-beta-L-fucose + Galbeta(1-3)GalNAc
GDP + Fucalpha(1-2)Galbeta(1-3)GalNAc
-
-
-
-
ir
GDP-beta-L-fucose + Galbeta(1-3)GalNAc
GDP + L-Fucalpha(1-2)Galbeta(1-3)GalNAc
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-
-
-
?
GDP-beta-L-fucose + Galbeta(1-3)GalNAcalpha-O-p-nitrophenol
GDP + Fucalpha(1-2)Galbeta(1-3)GalNAcalpha-O-p-nitrophenol
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-
-
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ir
GDP-beta-L-fucose + Galbeta(1-3)GalNAcalpha-OMe
GDP + Fucalpha(1-2)Galbeta(1-3)GalNAcalpha-OMe
GDP-beta-L-fucose + Galbeta(1-3)GalNAcalpha-R
GDP + Fucalpha(1-2)Galbeta(1-3)GalNAcalpha-R
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-
-
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ir
GDP-beta-L-fucose + Galbeta(1-3)GlcNAcbeta(1-3)Galbeta(1-4)Glc-beta-O-PA8
?
-
-
-
-
?
GDP-beta-L-fucose + Galbeta(1-3)GlcNAcbeta-O-p-nitrophenol
GDP + Fucalpha(1-2)Galbeta(1-3)GlcNAcbeta-O-p-nitrophenol
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activity is low
-
-
ir
GDP-beta-L-fucose + Galbeta(1-3)[Fucalpha(1-4)]GlcNAc
GDP + Fucalpha(1-2)Galbeta(1-3)[Fucalpha(1-4)]GlcNAc
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activity is low
-
-
ir
GDP-beta-L-fucose + Galbeta(1-3)[GlcNAcbeta(1-6)]GalNAcalpha-O-p-nitrophenol
GDP + Fucalpha(1-2)Galbeta(1-3)[GlcNAcbeta(1-6)]GalNAcalpha-O-p-nitrophenol
-
-
-
-
ir
GDP-beta-L-fucose + Galbeta-4-nitrophenyl
?
28% activity compared to D-lactose
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-
?
GDP-beta-L-fucose + Galbeta-O-Me
GDP + L-Fucalpha(1-2)Galbeta-O-Me
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-
-
-
?
GDP-beta-L-fucose + Galbeta-p-nitrophenol
GDP + L-Fucalpha(1-2)Galbeta-p-nitrophenol
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-
-
-
?
GDP-beta-L-fucose + phenyl 2-acetamido-2-deoxy-3-O-beta-D-galactopyranosyl-alpha-D-galactopyranoside
GDP + phenyl L-fucosyl-alpha (1->2)-D-Gal-beta-(1->3)-alpha-D-GalNAc
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-
-
-
?
GDP-beta-L-fucose + phenyl beta-D-galactopyranoside
GDP + phenyl alpha-L-fucosyl-(1->2)-beta-D-galactopyranoside
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-
-
?
GDP-beta-L-fucose + phenyl beta-D-thiogalactopyranoside
GDP + phenyl L-fucosyl-alpha-(1->2)-beta-D-thiogalactopyranoside
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-
-
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?
GDP-fucose + Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc
Fucalpha1-2Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc + GDP
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-
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?
GDP-L-Fuc + XLLGXLLG-2-aminopyridine
GDP + alpha-L-fucosyl-XLLGXLLG-2-aminopyridine
acceptor xyloglucan oligosaccharide carrying two repeated XLLG units plus 2-aminopyridine
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-
?
GDP-L-fucose + 6-sulfoGalbeta(1-4)GlcNAcbeta-O-methyl
GDP + L-Fucalpha(1-2)6-sulfoGalbeta(1-4)GlcNAcbeta-O-methyl
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-
-
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?
GDP-L-fucose + agalacto-asialofetuin
GDP + alpha-L-fucosyl-1,2-agalacto-asialofetuin
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-
-
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?
GDP-L-fucose + arabinogalactan protein
?
-
isoforms FUT4.1 and FUT 6 incorporate terminal alpha-L-fucose residues on the C-2 positions of adjacent arabinose residues of arabinogalactan proteins
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-
?
GDP-L-fucose + asialo alpha1 acid glycoprotein
GDP + alpha-L-fucosyl-1,2-asialo alpha1 acid glycoprotein
-
-
-
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?
GDP-L-fucose + beta-D-galactose-beta-O-2-(2-carbomethoxyethylthio)ethyl
?
-
-
-
-
?
GDP-L-fucose + beta-methyl-D-galactopyranoside
GDP + alpha-L-fucosyl-1,2-beta-methyl-D-galactopyranoside
-
-
-
-
?
GDP-L-fucose + D-Galbeta(1-2)D-Xylalpha(1-6)D-Glcbeta(1-4)D-Glc
GDP + L-Fucalpha(1-2)-D-Galbeta1-2-D-Xylalpha1-6-D-Glcbeta1-4-D-Glc
GDP-L-fucose + Galalpha(1-3)Galbeta(1-4)GlcNAcbeta(1-3)Galbeta(1-4)Glc-ceramide
GDP + L-Fucalpha(1-2)Galalpha(1-3)Galbeta(1-4)GlcNAcbeta(1-3)Galbeta(1-4)Glc-ceramide
-
-
-
?
GDP-L-fucose + GalalphaCH3
GDP + L-Fucalpha(1-2)GalalphaCH3
-
0.1% of the activity with Galbeta1-3GalNAc
-
-
?
GDP-L-fucose + Galbeta(1-3)Ara
GDP + L-Fucalpha(1-2)Galbeta(1-3)Ara
-
3.3% of the activity with Galbeta1-3GalNAc
-
-
?
GDP-L-fucose + Galbeta(1-3)GalNAcbeta(1-4)(NeuAcalpha(2-3))Galbeta(1-4)Glcbeta1-ceramide
GDP + L-Fucalpha(1-2)Galbeta(1-3)GalNAcbeta(1-4)(NeuAcalpha(2-3))Galbeta(1-4)Glcbeta1-cera mide
-
-
-
?
GDP-L-fucose + Galbeta(1-3)GalNAcbeta1-OCH2CH=CH2
GDP + L-Fucalpha(1-2)Galbeta(1-3)GalNAcbeta1-OCH2CH=CH2
-
-
-
-
?
GDP-L-fucose + Galbeta(1-3)GlcNAcbeta(1-3)Galbeta(1-4)Glc
GDP + L-Fucalpha(1-2)Galbeta(1-3)GlcNAcbeta(1-3)Galbeta(1-4)Glc
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84% of the activity with Galbeta1-3GalNAc
-
-
?
GDP-L-fucose + Galbeta(1-3)GlcNAcbeta-O-allyl/acrylamide copolymer
GDP + ?
-
-
-
-
?
GDP-L-fucose + Galbeta(1-3)GlcNAcbeta-O-benzyl
GDP + L-Fucalpha(1-2)Galbeta(1-3)GlcNAcbeta-O-benzyl
-
-
-
-
?
GDP-L-fucose + Galbeta(1-4)Glc
GDP + L-Fucalpha(1-2)Galbeta(1-4)Glc
-
4.2% of the activity with Galbeta1-3GalNAc
-
-
?
GDP-L-fucose + Galbeta(1-4)Glc-beta-O-2-(2-carbomethoxyethylthio)ethyl
GDP + L-Fucalpha(1-2)Galbeta(1-4)Glc-beta-O-2-(2-carbomethoxyethylthio)ethyl
-
-
-
-
?
GDP-L-fucose + Galbeta(1-4)GlcNAc
GDP + L-Fucalpha(1-2)Galbeta(1-4)GlcNAc
-
7.5% of the activity with Galbeta1-3GalNAc
-
-
?
GDP-L-fucose + Galbeta(1-4)GlcNAc(1-3)Galbeta(1-4)Glc
GDP + L-Fucalpha(1-2)Galbeta(1-4)GlcNAc(1-3)Glabeta(1-4)Glc
-
2.8% of the activity with Galbeta(1-3)GalNAc
-
-
?
GDP-L-fucose + Galbeta(1-4)GlcNAc-beta-O-2-(2-carbomethoxyethylthio)ethyl
GDP + L-Fucalpha(1-2)Galbeta(1-4)Glc-beta-O-2-(2-carbomethoxyethylthio)ethyl
-
-
-
-
?
GDP-L-fucose + Galbeta(1-4)GlcNAcbeta(1-3)Galbeta(1-4)Glc-ceramide
GDP + L-Fucalpha(1-2)Galbeta(1-4)GlcNAcbeta(1-3)Galbeta(1-4)Glc-ceramide
-
-
-
-
?
GDP-L-fucose + Galbeta(1-4)GlcNAcbeta-O-benzyl
GDP + L-Fucalpha(1-2)Galbeta(1-4)GlcNAcbeta-O-benzyl
-
-
-
-
?
GDP-L-fucose + Galbeta(1-4)Man
GDP + L-Fucalpha(1-2)Galbeta(1-4)Man
-
2.7% of the activity with Galbeta1-3GalNAc
-
-
?
GDP-L-fucose + Galbeta(1->3)-GalNAcalpha-OH
GDP + Fucalpha(1->2)-Galbeta(1->3)-GalNAcalpha-OH
GDP-L-fucose + Galbeta(1->3)-GalNAcalpha-OMe
GDP + Fucalpha(1->2)-Galbeta(1->3)-GalNAcalpha-OMe
GDP-L-fucose + GalbetaCH3
GDP + L-Fucalpha(1-2)GalbetaCH3
-
2.6% of the activity with Galbeta1-3GalNAc
-
-
?
GDP-L-fucose + intestinal glycoprotein
GDP + alpha-L-fucosyl-1,2-intestinal glycoprotein
-
-
-
-
?