Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.69 extracted from

  • Chandrasekaran, E.V.; Chawda, R.; Locke, R.D.; Piskorz, C.F.; Matta, K.L.
    Biosynthesis of the carbohydrate antigenic determinants, Globo H, blood group H, and Lewis b: a role for prostate cancer cell alpha1,2-L-fucosyltransferase (2002), Glycobiology, 12, 153-162.
    View publication on PubMed
Search for more literature for 2.4.1.69

Inhibitors

Inhibitors Comment Organism Structure
NEM
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ 20 mM, 50% stimulation Homo sapiens
Mg2+ stimulates to a maximum at 30 mM Homo sapiens
Mn2+ stimulates to a maximum at 10 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GDP-L-fucose + beta-D-galactosyl-R Homo sapiens enzyme is involved in expression of blood group H, Lewis b from Lewis a and Globo H GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell
-
 Homo sapiens
-
PC-3 cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-L-fucose + beta-D-galactosyl-R acceptor specificity, overview. C6-sulfation of terminal Gal in the LacNAc unit increases acceptor efficiency, C-6 sialylation abolishes acceptor ability, C6-sulfation of GlcNAc in LacNAc type 2 decreases by 80% the acceptor ability, whereas LacNAc type 1 is unaffected, the C-4 hydroxyl rather than the C-6 hydroxyl group of the GlcNAc moiety in LacNAc type 1 is essential for activity, the acrylamide copolymer of Galbeta(1-3)GlcNAcbeta-O-Al is the best acceptor among the acrylamide copolymers, Lewis x does not serve as an acceptor Homo sapiens GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
 ?
GDP-L-fucose + beta-D-galactosyl-R enzyme is involved in expression of blood group H, Lewis b from Lewis a and Globo H Homo sapiens GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0125
-
 NEM
-
 Homo sapiens