Literature summary for 2.4.1.69 extracted from

Meng, D.; Newburg, D.S.; Young, C.; Baker, A.; Tonkonogy, S.L.; Sartor, R.B.; Walker, W.A.; Nanthakumar, N.N.
Bacterial symbionts induce a FUT2-dependent fucosylated niche on colonic epithelium via ERK and JNK signaling (2007), Am. J. Physiol. Gastrointest. Liver Physiol., 293, G780-G787.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colonic epithelium	gut colonization by symbiotic bacteria stimulates ERK and JNK signal transduction pathways, resulting in activation of transcription factors ATF2 and c-Jun, respectively. This increases transcription of fut2 mRNA and expression of alpha1,2/3-fucosyltransferase activity, resulting in a highly fucosylated intestinal mucosa characteristic of the adult mammalian gut. Blocking the ERK and JNK signaling cascade inhibits the ability of colonization to induce elevated fut2 mRNA and fucosyltransferase activity in the mature colon	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
fucosyltransferase 2	-	Homo sapiens
FUT2	-	Homo sapiens

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Release 2023.1 (January 2023)