EC Number   |
Application |
Reference |
|---|
   2.4.1.69 | analysis |
determination of GDP-L-fucose:galactoside 2'-fucosyltransferase in human serum employing o-nitrophenyl-beta-D-galactopyranoside, phenyl-2-acetamido-2-deoxy-3-O-beta-D-galactopyranosyl-alpha-D-galactopyranoside, or phenyl beta-D-thiogalactopyranoside as acceptors. The method can simultaneously monitor possible competing reactions which may interfere with determination of alpha-2-L-fucosyltransferase activity |
740330 |
| 2.4.1.69 | medicine |
alpha-galactosidase and alpha-1,2-fucosyltransferase can inhibit the expression of Gal-alpha-1,3-Gal synergistically, leading to stronger resistance of xenograft against cytolysis mediated by natural antibodies and complements. It implies a practical significance of combined transgenic strategy with alpha galactosidase and alpha-1,2-fucosyltransferase |
657489 |
| 2.4.1.69 | medicine |
co-expression of the enzyme with 1,3-galactosyltransferase leads to a considerable reduction of the alpha-Gal antigen level on the surface of cells and a decrease of xenotransplant immunogenicity |
735564 |
| 2.4.1.69 | medicine |
FUT1 can efficiently prevent the synthesis of slex antigens in hepatocarcinoma and colon carcinoma cells and their interaction with activated endothelia. The FUT-EGFP gene transfer approach would be expected to decrease or even suppress the initial vascular arrest of tumor cells and may provide a basis for the development of antimetastatic gene therapy |
657509 |
| 2.4.1.69 | medicine |
involvement of alpha 1-2-fucosyltransferase I (FUT1) and surface-expressed Lewis(y) (CD174) in first endothelial cell-cell contacts during angiogenesis is shown |
693324 |
| 2.4.1.69 | medicine |
it is shown that human alpha(1,2)-fucosyltransferase activity is remarkably decreased (40-90%) in human gastric cancer and may serve as a potential tumor marker |
680997 |
| 2.4.1.69 | medicine |
sequence variations in the proximal promoter region of FUT2 in several human populations is studied. In African populations, two SNPs (17606C>T and 17721T>G) with intermediate frequency that affected the promoter activity in vitro with a cell type-specific pattern are found |
690434 |
| 2.4.1.69 | medicine |
systematic sequence analysis of the human FUT2 gene in healthy chinese and caucasian subjects identifies 18 sequence variations in the FUT2 gene, and 6 are novel |
695220 |
| 2.4.1.69 | medicine |
tumor marker for human gastric cancer, down regulation of alpha1,2-fucosyltransferase activity is associated with human gastric tumorigenesis |
680997 |
| 2.4.1.69 | medicine |
using nude mice subcutaneously xenotransplanted with parental or FUT1-transduced hepatocarcinoma cells HepG2 it is shown that FUT1 displays a strong antitumorigenicity due to a defect in tumor vascularization |
692656 |
