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Literature summary for 2.4.1.69 extracted from
- Dictyostelium cytosolic fucosyltransferase synthesizes H type 1 trisaccharide in vitro (1996), FEBS Lett., 395, 68-72.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ATP | stimulates at low concentrations | Dictyostelium discoideum |  |
| fucose | stimulates | Dictyostelium discoideum | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-mercaptoethanol | complete inhibition of activity with lacto-N-biose I | Dictyostelium discoideum | |
| NEM | - |
Dictyostelium discoideum | |
| Triton X-100 | - |
Dictyostelium discoideum | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00127 | - |
GDP-L-fucose | - |
Dictyostelium discoideum | |
| 2.8 | - |
lacto-N-biose I | - |
Dictyostelium discoideum | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Dictyostelium discoideum | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | strong stimulation by Mg2+ and Mn2+ | Dictyostelium discoideum | |
| Mn2+ | strong stimulation by Mg2+ and Mn2+ | Dictyostelium discoideum | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Dictyostelium discoideum | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GDP-L-fucose + beta-D-galactosyl-R | - |
Dictyostelium discoideum | GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R | - |
? | |
| GDP-L-fucose + lacto-N-biose 1 | - |
Dictyostelium discoideum | GDP + L-Fucalpha(1-2)Galbeta(1-3)GlcNAc | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 23 | - |
- |
Dictyostelium discoideum |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 16 | 30 | 16°C: 61% of maximal activity, 30°C: 62% of maximal activity | Dictyostelium discoideum |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 100 | - |
complete inhibition by heating at 100°C | Dictyostelium discoideum |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.9 | - |
- |
Dictyostelium discoideum |
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