Ligand GDP

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure

Picture of GDP (click for magnification)

C₁₀H₁₅N₅O₁₁P₂

GDP

QGWNDRXFNXRZMB-UUOKFMHZSA-N

Synonyms:

D-GDP, guanosine 5'-diphosphate, guanosine 5'-O-diphosphate, guanosine diphosphate, ppG

BRENDA

alginate biosynthesis, ascorbate metabolism, citric acid cycle, d-mannose degradation, dolichyl-diphosphooligosaccharide biosynthesis

more

KEGG

Autophagy - animal, Endocytosis, Nucleotide metabolism, Purine metabolism, Rap1 signaling pathway

more

MetaCyc

ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide, ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide, acetan biosynthesis, adenosine ribonucleotides de novo biosynthesis, alginate biosynthesis I (algal)

more

Show all BRENDA pathways known for GDP

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (59 results)

top print hide

1.17.4.1

8 entries

2.7.2.10

GDP + 3-phospho-D-glyceroyl 1-phosphate = GTP + 3-phospho-D-glycerate

GDP + [phosphate]n = GMP + [phosphate]n+1

722511

2.7.4.34

GDP + (phosphate)n+1 = GTP + (phosphate)n

ATP + GDP = AMP + guanosine 3'-diphosphate 5'-diphosphate

739546, 738524

1vj7, 3D-view

2.7.7.22

GDP + alpha-D-mannose 1-phosphate = phosphate + GDP-mannose

697677, 760729, 700709

2.7.7.88

3 entries

3.6.1.15

GDP + H2O = GMP + phosphate

GDP + H2O = GMP + phosphate

700088, 733025, 700083, 756375, 720851, 755996, 756376

3.6.1.6

GDP + H2O = GMP + phosphate

756751, 733220, 755996, 757160, 210206

3.6.1.9

GDP + H2O = GMP + phosphate

GDP + H2O = GMP + phosphate

644170, 644171, 644175

In Vivo Product in Enzyme-catalyzed Reactions (463 results)

top print hide

2.4.1.110

GDP-alpha-D-mannose + queuosine34 in tRNAAsp = GDP + O-4''-alpha-D-mannosylqueuosine34 in tRNAAsp

GDP-mannose + GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-dicis,octatrans-undecaprenol = GDP + D-Man-beta-(1->4)-GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-dicis,octatrans-undecaprenol

GDP-glucose + 3-phospho-D-glycerate = GDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate

2.4.1.269

2 entries

2.4.1.270

GDP-mannose + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate = GDP + 2-(2-O-(alpha-D-mannopyranosyl)-alpha-D-glucopyranosyl)-3-phospho-D-glycerate

2.4.1.308

GDP-beta-L-fucose + beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol = GDP + alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol

2.4.1.32

GDP-D-mannose + (glucomannan)n = GDP + (glucomannan)n+1

489050, 489049

2.4.1.33

GDP-D-mannuronate + (alginate)n = GDP + (alginate)n+1

2.4.1.341

GDP-beta-L-colitose + beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine = GDP + alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine

GDP-glucose + glucose 6-phosphate = GDP + alpha,alpha-trehalose 6-phosphate

488618

2.4.1.348

GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol

2.4.1.349

GDP-alpha-D-mannose + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = GDP + alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol

2.4.1.353

2 entries

2.4.1.36

GDP-glucose + glucose 6-phosphate = GDP + alpha,alpha-trehalose 6-phosphate

489111, 0

2.4.1.361

2 entries

2.4.1.370

GDP-alpha-D-mannose + a very-long-chain inositol phospho-(2'R)-2'-hydroxyphytoceramide = a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide + GDP

2.4.1.383

GDP-alpha-D-mannose + alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und = GDP + beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und

2.4.1.48

GDP-mannose + heteroglycan = GDP + 1,2(or 1,3)-alpha-D-mannosylheteroglycan

GDP-alpha-D-mannose + 1,2-di-O-C16/C18:1-(alpha-D-glucopyranosyluronic acid)-(1->3)-glycerol = GDP + 1,2-di-O-C16/C18:1-(alpha-D-mannopyranosyl)-(1->4)-(alpha-D-glucopyranosyluronic acid)-(1->3)-glycerol

2.5.1.135

GDP-valienol + validamine 7-phosphate = validoxylamine A 7'-phosphate + GDP

GTP + 1-(beta-D-ribofuranosyl)-nicotinamide = GDP + beta-nicotinamide D-ribonucleotide

2.7.1.33

3 entries

2.7.1.81

GTP + 5-hydroxy-L-lysine = GDP + O-phosphohydroxy-L-lysine

GTP + AMP = GDP + ADP

2.7.4.33

GMP + [phosphate]n = GDP + [phosphate]n-1

2.7.4.34

GTP + (phosphate)n = GDP + (phosphate)n+1

2.7.4.8

8 entries

2.7.6.5

guanosine 3'-diphosphate 5'-diphosphate + H2O = GDP + diphosphate

1vj7, 3D-view

2.7.7.22

GDPmannose + phosphate = GDP + mannose 1-phosphate

643055, 393092

2.7.7.69

GDP-beta-L-galactose + phosphate = GDP + beta-L-galactose 1-phosphate

2.7.7.78

GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP

2.7.8.9

GDP-mannose + endogenous acceptor molecule = GDP + endogenous acceptor molecule modified

643804

3.1.7.2

ppGpp + H2O = ppG + diphosphate

0, 135701, 135697, 135698, 135700, 135702, 135703, 135699, 135704, 135705

1vj7, 3D-view

3.2.1.24

GDP-mannosylpyranose + H2O = alpha-D-mannopyranose + GDP

136006, 136007

3.2.1.42

GDP-glucose + H2O = GDP + D-glucose

136441

3.6.1.15

GTP + H2O = GDP + phosphate

3.6.1.5

GTP + H2O = GDP + phosphate

3.6.4.B7

GTP + H2O = GDP + phosphate

GTP + H2O = GDP + phosphate

644173, 0, 644166, 644170, 644176, 644164, 644171, 644163, 644167, 644168, 644169, 644177, 644180, 644165, 644172, 644175, 644174, 644178, 644179

GTP + H2O = GDP + phosphate

5.6.1.3

GTP + H2O + a kinesin associated with a microtubule at position n = GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)

6.2.1.4

3 entries

6.2.1.B11

GTP + acetate + CoA = GDP + phosphate + acetyl-CoA

6.3.2.31

2 entries

6.3.2.33

GTP + tetrahydromethanopterin + L-glutamate = GDP + phosphate + 5,6,7,8-tetrahydrosarcinapterin

GTP + H2O + antigen peptide[side 1] = GDP + phosphate + antigen peptide[side 2]

Substrate in Enzyme-catalyzed Reactions (253 results)

GDP + reduced thioredoxin = dGDP + oxidized thioredoxin + H2O

437889, 437888

2.1.1.56

S-adenosyl-L-methionine + GDP = S-adenosyl-L-homocysteine + m7GDP

674439

6rie, 3D-view

2.4.1.13

GDP + sucrose = GDP-alpha-D-glucose + D-fructose

756234

2.4.1.245

alpha,alpha-trehalose + GDP = GDP-alpha-D-glucose + D-glucose

723675, 747674

2.5.1.112

dimethylallyl diphosphate + GDP = ?

671796

2.5.1.27

dimethylallyl diphosphate + GDP = ?

671796

2.7.1.146

D-fructose 6-phosphate + GDP = D-fructose 1,6-bisphosphate + GMP

698924

2.7.1.147

GDP + D-glucose = GMP + D-glucose 6-phosphate

738699, 660867, 727486

2.7.1.20

GDP + adenosine = GMP + AMP

GDP + phosphoenolpyruvate = GTP + pyruvate

641606, 692317, 641516, 641562, 641584, 641570, 641556, 641578, 641523, 641567, 641558, 641576, 641532, 641589, 708992

2.7.11.1

17 entries

2.7.2.10

GDP + 3-phospho-D-glyceroyl 1-phosphate = GTP + 3-phospho-D-glycerate

703640, 645109

2.7.3.3

GDP + Nomega-phospho-L-Arg = GTP + L-Arg

642450

2.7.3.8

GDP + phosphoramide = GTP + NH3

GDP + trans-farnesyl diphosphate = GMP + trans-farnesyl triphosphate

GDP + (phosphate)n+1 = GTP + (phosphate)n

ATP + GDP = diphosphate + ?

642991

2.7.7.22

GDP + alpha-D-mannose 1-phosphate = phosphate + GDP-mannose

697677, 700709, 760729

2.7.7.45

2 entries

2.7.7.5

GDP + phosphate = phosphate + GDP

p-tRNAHis + ATP + GDP = ?

712336

2.7.7.8

poly(G) + GDP = poly(G)+1 + phosphate

643680, 643679, 643713, 643698, 643686, 643683, 643687, 643684, 643711

GDP + H2O = ?

GDP + H2O = ?

glucose + GDP = glucose 6-phosphate + GMP

GDP + H2O = ?

GDP + H2O = ?

GDP + H2O = GMP + phosphate

696153, 696275

3.6.1.29

adenosine 5'-phosphoimidazolide + GDP = imidazole + A(5')p3(5')G

GDP + H2O = GMP + phosphate

667672

3.6.1.56

GDP + H2O = GMP + phosphate

757347

3.6.1.58

GDP + H2O = GMP + phosphate

716365

3.6.1.6

GDP + H2O = GMP + phosphate

210202, 210205, 210206, 210208, 210213, 210216, 210217, 720736, 669238, 670350, 756751, 733220, 755996, 757160, 756218, 654678, 210204, 656961, 656079

3.6.1.62

GDP + H2O = GMP + phosphate

758123

3.6.1.64

GDP + H2O = GMP + phosphate

GDP + H2O = ?

GDP + H2O = GMP + phosphate

644170, 644171, 644175

4.1.1.32

32 entries

6.2.1.13

GDP + phosphate + acetyl-CoA = GTP + acetate + CoA

626, 627, 625, 744820

6.2.1.4

3 entries

6.2.1.B11

GDP + phosphate + acetyl-CoA = GTP + acetate + CoA

744820

6.5.1.1

ATP + GDP = P1-(5'-adenosyl),P3-(5'-guanosyl)triphosphate + diphosphate

722217

7.2.2.1

GDP + phosphate + Na+/out = GTP + H2O + Na+/in

654801

Product in Enzyme-catalyzed Reactions (2342 results)

[elongator tRNAMet]-cytidine34 + GTP + acetyl-CoA = [elongator tRNAMet]-N4-acetylcytidine34 + GDP + phosphate + coenzyme A

2.3.2.13

2 entries

2.3.3.8

GTP + citrate + CoA = GDP + phosphate + acetyl-CoA + oxaloacetate

2.4.1.11

GDP-glucose + (1,4-alpha-D-glucosyl)n = GDP + (1,4-alpha-D-glucosyl)n+1

2.4.1.110

GDP-alpha-D-mannose + queuosine34 in tRNAAsp = GDP + O-4''-alpha-D-mannosylqueuosine34 in tRNAAsp

488453