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Literature summary for 3.4.21.B12 extracted from

  • Mukai, S.; Yorita, K.; Yamasaki, K.; Nagai, T.; Kamibeppu, T.; Sugie, S.; Kida, K.; Onizuka, C.; Tsukino, H.; Kamimura, T.; Kamoto, T.; Kataoka, H.
    Expression of human kallikrein 1-related peptidase 4 (KLK4) and MET phosphorylation in prostate cancer tissue: immunohistochemical analysis (2015), Hum. Cell, 28, 133-142.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasma hepatocyte growth factor activator zymogen + H2O Homo sapiens activation, hepatocyte growth factor is mainly secreted from fibroblasts as an inactive single-chain precursor, which lacks biological activity mature HGF activator + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9YSK2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate cancer cell expression of human kallikrein 1-related peptidase 4 in prostate cancer patients with bone metastasis or advanced stage, immunohistochemic analysis of 62 prostate cancer samples Homo sapiens
-
prostate gland very low enzyme levels in healthy tissue Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasma hepatocyte growth factor activator zymogen + H2O activation, hepatocyte growth factor is mainly secreted from fibroblasts as an inactive single-chain precursor, which lacks biological activity Homo sapiens mature HGF activator + ?
-
?
plasma hepatocyte growth factor activator zymogen + H2O conversion to an active two-chain form Homo sapiens mature HGF activator + ?
-
?

Synonyms

Synonyms Comment Organism
kallikrein 1-related peptidase 4
-
Homo sapiens
KLK4
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme activates the hepatocyte growth factor, a multifunctional growth factor that plays an important role in cancer progression via its specific receptor tyrosine kinase MET, a c-met proto-oncogene product. Correlation between phospho-MET, MET, KLK4 expression and clinicopathological parameters, overview Homo sapiens