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Literature summary for 3.4.21.122 extracted from

  • Wilson, S.; Greer, B.; Hooper, J.; Zijlstra, A.; Walker, B.; Quigley, J.; Hawthorne, S.
    The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells (2005), Biochem. J., 388, 967-972 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine treatment of LNCaP cells with a cellular immunopurified TMPRSS2 protease induces a transient increase in intracellular calcium. This calcium mobilization is inhibited by cellular pretreatment with a specific PAR-2 antagonist and also by cellular pretreatment with suramin or 2-APB (2-aminoethoxydiphenyl borate) Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O15393
-
-

Purification (Commentary)

Purification (Comment) Organism
from prostate cancer cells, via a polyclonal anti-human TMPRSS2 antibody Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
LNCaP cell
-
 Homo sapiens
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prostate gland
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
epitheliasin
-
 Homo sapiens
TMPRSS2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function treatment of LNCaP cells with a cellular immunopurified TMPRSS2 protease induces a transient increase in intracellular calcium. This calcium mobilization is inhibited by cellular pretreatment with a specific PAR-2 antagonist and also by cellular pretreatment with suramin or 2-APB (2-aminoethoxydiphenyl borate) Homo sapiens