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ATP + a protein
ADP + a phosphoprotein
ATP + activating transcription factor 2
ADP + phosphorylated activating transcription factor 2
ATP + AP1
ADP + phosphorylated AP1
ATP + Arabidopsis thaliana protein AT1G7815
ADP + phosphorylated Arabidopsis thaliana proteins AT1G78150
-
-
?
ATP + Arabidopsis thaliana protein AT2G26530
ADP + phosphorylated Arabidopsis thaliana proteins AT2G26530
-
-
?
ATP + Arabidopsis thaliana protein AT3G11330
ADP + phosphorylated Arabidopsis thaliana proteins AT3G11330
-
-
?
ATP + Arabidopsis thaliana protein AT4G38710
ADP + phosphorylated Arabidopsis thaliana proteins AT4G38710
-
-
?
ATP + ATF-2
ADP + phosphorylated ATF-2
ATP + ATF2
ADP + a phosphorylated ATF2
substrate in assay, biotinylated ATF2
-
?
ATP + ATF2
ADP + phosphorylated ATF2
ATP + ATF2DELTA109
ADP + phosphorylated ATF2DELTA109
-
-
-
?
ATP + Axl2
ADP + phospho-Axl2
-
substrate of Hog1
-
?
ATP + Bcl-2
ADP + phosphorylated Bcl-2
-
-
?
ATP + BES1
ADP + phosphorylated BES1
ATP + c-Jun
ADP + phosphorylated c-Jun
ATP + c-Jun activation domain
ADP + phosphorylated c-Jun activation domain
ATP + c-Jun transcription factor
ADP + phosphorylated c-Jun transcription factor
-
JNK phosphorylates the N-terminal transactivation domain of c-Jun transcription factor
-
?
ATP + casein
ADP + phosphocasein
-
substrate of Hog1
-
?
ATP + cdc42
ADP + phosphorylated cdc42
-
substrate of Gic2
-
?
ATP + DNA polymerase II
ADP + phosphorylated DNA polymerase II
-
substrate of Hog1p
-
?
ATP + EB1c
ADP + phosphorylated EB1c
ATP + EGF receptor peptide
ADP + phosphorylated EGF receptor peptide
-
-
-
?
ATP + Elk-1
ADP + phosphorylated Elk-1
ATP + Elk1
ADP + phosphorylated Elk1
ATP + ELKERK
?
-
ERK1
-
?
ATP + ERKMEK1
?
-
ERK1
-
?
ATP + ERKMEK2
?
-
ERK1
-
?
ATP + ERKSTE7
?
-
ERK1
-
?
ATP + ERKSub
?
-
ERK1 and p38alpha kinase
-
?
ATP + Ets-1
ADP + phosphorylated Ets-1
-
-
-
?
ATP + FITC-Aca-Ala-Ala-Ala-Thr-Gly-Pro-Leu-Ser-Pro-Gly-Pro-Phe-Ala-NH2
ADP + phosphorylated FITC-Aca-Ala-Ala-Ala-Thr-Gly-Pro-Leu-Ser-Pro-Gly-Pro-Phe-Ala-NH2
-
FITC-labeled ERK substrate peptide
-
?
ATP + focal adhesion kinase
ADP + phosphorylated focal adhesion kinase
phosphorylation of FAK at S910, which promotes the disassembly of focal adhesion (hemidesmosome disruption) during cell migration
-
?
ATP + Gic2
ADP + phosphorylated Gic2
-
substrate of Fus3, and of Hog1
-
?
ATP + GLH-1
ADP + phosphorylated GLH-1
-
-
?
ATP + GST-c-Jun
ADP + phosphorylated GST-c-Jun
-
substrate in kinase activity assay
-
?
ATP + histone H1
ADP + phospho-histone H1
-
substrate of Hog1
-
?
ATP + Hog1D
ADP + phospho-Hog1D
-
substrate of Hog1
-
?
ATP + Hot1p
ADP + phosphorylated Hot1p
ATP + Hsl1
ADP + phospho-Hsl1
-
substrate of Hog1
-
?
ATP + human glucocorticoid receptor
ADP + phosphorylated human glucocorticoid receptor
ATP + IRS-1
ADP + phosphorylated IRS-1
-
phosphorylation of the insulin receptor substrate IRS-1 at serine 307
-
?
ATP + JunD
ADP + phosphorylated JunD
-
-
-
?
ATP + Lin-1
ADP + phosphorylated Lin-1
ATP + MAP65-1
ADP + phosphorylated MAP65-1
microtubule-associated protein, phosphorylation in vitro by MPK6, recombinant GST-tagged substrate protein
-
?
ATP + MAPK
ADP + phosphorylated MAPK
-
-
-
?
ATP + MAPKAP kinase-2
ADP + phosphorylated MAPKAP kinase-2
-
-
?
ATP + MAPKAP kinase-3
ADP + phosphorylated MAPKAP kinase-3
-
-
?
ATP + MAPKAP-K2
ADP + phosphorylated MAPKAP-K2
-
-
-
?
ATP + MAPKAP-K3
ADP + phosphorylated MAPKAP-K3
-
-
-
?
ATP + MAPKAPK2
ADP + phosphorylated MAPKAPK2
-
-
?
ATP + MAPKAPK2-peptide
ADP + phosphorylated MAPKAPK2-peptide
-
the peptide substrate is derived from a sequence of a mitogen-activated protein kinase activated protein kinase-2, MAPKAPK2, phopshorylation site
-
?
ATP + MBP
ADP + phospho-MBP
-
substrate of Hog1
-
?
ATP + MEF2
ADP + phosphorylated MEF2
-
-
-
?
ATP + MEK
ADP + phosphorylated MEK
-
-
binding to ERK requires docking domain and the kinase interaction motif
?
ATP + Mek1
ADP + phospho-Mek1
-
substrate of Hog1
-
?
ATP + MEK1ERK
?
-
ERK1 and p38alpha kinase
-
?
ATP + MEK2ERK
?
-
ERK1 and p38alpha kinase
-
?
ATP + MK2
ADP + phosphorylated MK2
ATP + MKS1
ADP + phosphorylated MSK1
ATP + MMP-9
ADP + phosphorylated MMP-9
ATP + Mps1
ADP + phosphorylated Mps1
-
Mps1 phosphorylation by MAPK at S844, spindle checkpoint requires phosphorylation at S844, may create a phosphoepitope that allows Mps1 to interact with kinetochores
-
?
ATP + multifunctional protein CAD
ADP + phosphorylated multifunctional protein CAD
ATP + myelin basic protein
ADP + a phosphorylated myelin basic protein
-
substrate in kinase assay
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
ATP + Net
ADP + phosphorylated Net
ATP + p38
ADP + phosphorylated p38
-
-
-
?
ATP + phospholipase C-gamma1
ADP + phosphorylated phospholipase C-gamma1
ATP + protein
ADP + phosphoprotein
ATP + protein APP
ADP + phosphorylated protein APP
-
-
?
ATP + protein ATF2
ADP + phosphorylated protein ATF2
ATP + protein EGFRP
ADP + phosphorylated protein EGFRP
-
epidermal growth factor receptor peptide, substrate in kinase activity assay
-
?
ATP + protein tyrosine kinase 2
ADP + phosphorylated protein tyrosine kinase 2
-
substrate of Hog1
-
?
ATP + RAD9
ADP + phospho-RAD9
-
high activity with Fus3, low activity with Hog1
-
?
ATP + RAD9p
ADP + phospho-RAD9p
-
substrate of Hog1
-
?
ATP + Rck2
ADP + phosphorylated Rck2
-
-
-
?
ATP + Red1
ADP + phospho-Red1
-
preferred substrate of Hog1
-
?
ATP + RSK
ADP + phosphorylated RSK
-
-
binding to ERK requires docking domain
?
ATP + SCRAMMMEK2
?
-
ERK1
-
?
ATP + Smad1
ADP + phosphorylated Smad1
ATP + Smad3
ADP + phosphorylated Smad3
ATP + sodium channel Na(v)1.6
ADP + phosphorylated sodium channel Na(v)1.6
-
-
-
?
ATP + sodium channel Na(v)1.7
ADP + phosphorylated sodium channel Na(v)1.7
-
-
-
?
ATP + sodium channel Na(v)1.8
ADP + phosphorylated sodium channel Na(v)1.8
-
-
-
?
ATP + Ste50
ADP + phosphorylated Ste50
ATP + STE7ERK
?
-
ERK1
-
?
ATP + Swe1
ADP + phospho-Swe1
-
substrate of Hog1
-
?
ATP + Swi6
ADP + phospho-Swi6
-
substrate of Hog1
-
?
ATP + TBP
ADP + phosphorylated TBP
-
substrate of p38 MAPK
-
?
ATP + transcription factor ATF2
ADP + phosphorylated transcription factor ATF2
-
-
?
ATP + transcription factor Djun
ADP + phosphorylated transcription factor Djun
-
-
?
ATP + transcription factor Elk-1
ADP + phosphorylated transcription factor Elk-1
-
-
?
ATP + transcription factor SAP-1
ADP + phosphorylated transcription factor SAP-1
-
-
?
ATP + Tub4p
ADP + phospho-Tub4
-
substrate of Hog1
-
?
ATP + tyrosine hydroxylase
ADP + phosphorylated tyrosine hydroxylase
ATP + WRKY25
ADP + phosphorylated WRKY25
-
the transcription factor is an in vitro substrate of MPK4
-
?
ATP + WRKY33
ADP + phosphorylated WRKY33
-
the transcription factor is an in vitro substrate of MPK4
-
?
ATPgammaS + myelin basic protein
ADP + thiophosphorylated myelin basic protein
Arabidopsis thaliana MPKs use ATPgammaS to thiophosphorylate myelin basic protein
-
?
N6-benzyl-ATPgammaS + myelin basic protein
ADP + benzylthiophosphorylated myelin basic protein
Arabidopsis thaliana MPK3 mutant T119A uses N6-benzyl-ATPgammaS to thiophosphorylate myelin basic protein
-
?
phosphoprotein
?
-
the MAPK is regulated in the MAPK signaling cascade by 2 mechanisms: 1. by MEK, EC 2.7.11.25, docking at the allosteric ED domain or the CD domain of MAPKs, or 2. by MKK7, MLK, JNK or MKP-7 docking at the scaffolding protein JIP in the JNK signaling pathway
-
?
additional information
?
-
ATP + a protein

ADP + a phosphoprotein
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
ERK2 phosphorylates MBP, p38 phosphorylates the protein substrate MAPKAP2 and the peptide substrate KRELVEPLTPSGEAPNQALLR, other substrates of MAPK are transcription factors, such as c-Jun, ATF-2, and MEF2A
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
702641, 702692, 702942, 703019, 703255, 703573, 704471, 705276, 705321, 705447, 706080, 706863 -
?
ATP + a protein
ADP + a phosphoprotein
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
?
ATP + a protein
ADP + a phosphoprotein
MAPK activate mitogen-activated proteins in several signal transduction pathways, overview
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
?
ATP + activating transcription factor 2

ADP + phosphorylated activating transcription factor 2
-
ATF2
-
?
ATP + activating transcription factor 2
ADP + phosphorylated activating transcription factor 2
-
ATF2, recombinant GST-tagged ATF2DELTA115
-
?
ATP + AP1

ADP + phosphorylated AP1
-
substrate of ERK1/2, ERK access to the substrate is regulated by the all-trans retinoic acid receptor, RAR
-
?
ATP + AP1
ADP + phosphorylated AP1
-
substrate of ERK1/2
-
?
ATP + ATF-2

ADP + phosphorylated ATF-2
-
-
-
?
ATP + ATF-2
ADP + phosphorylated ATF-2
assay substrate biotinylated ATF-2
-
?
ATP + ATF-2
ADP + phosphorylated ATF-2
-
substrate in kinase activity assay
-
?
ATP + ATF-2
ADP + phosphorylated ATF-2
-
substrate in kinase assay
-
?
ATP + ATF2

ADP + phosphorylated ATF2
-
-
?
ATP + ATF2
ADP + phosphorylated ATF2
-
substrate in in vitro kinase assay, LanthaScreen
-
?
ATP + ATF2
ADP + phosphorylated ATF2
phosphorylation by p38 MAPK at threonine residues
-
?
ATP + BES1

ADP + phosphorylated BES1
i.e. brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1, an Arabidospis thaliana transcription factor. S286 and S137 residues are required for flg22-induced BES1 full phosphorylation in vivo, in which S286 plays a greater role than S137
-
?
ATP + BES1
ADP + phosphorylated BES1
i.e. brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1, an Arabidospis thaliana transcription factor
-
?
ATP + BES1
ADP + phosphorylated BES1
i.e. brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1, an Arabidospis thaliana transcription factor. S286 and S137 residues are required for flg22-induced BES1 full phosphorylation in vivo, in which S286 plays a greater role than S137
-
?
ATP + BES1
ADP + phosphorylated BES1
i.e. brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1, an Arabidospis thaliana transcription factor
-
?
ATP + c-Jun

ADP + phosphorylated c-Jun
-
activity assay
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
-
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
-
-
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
-
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
-
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
substrate of JNK
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
substrate of JNK, binding via delta domain of c-Jun substrate
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
-
-
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
the reaction is performed by activated phosphorylated ERK2
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
the reaction is performed by activated phosphorylated JNK3
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
recombinant GST-tagged substrate, the reaction is performed by activated phosphorylated ERK2
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
recombinant GST-tagged substrate, the reaction is performed by activated phosphorylated JNK3
-
?
ATP + c-Jun activation domain

ADP + phosphorylated c-Jun activation domain
enzyme binds to the c-Jun transactivation domain and phosphorylates it on Ser63 and Ser73
-
?
ATP + c-Jun activation domain
ADP + phosphorylated c-Jun activation domain
JNK2 binds c-Jun approximately 25 times more efficiently than JNK1
-
?
ATP + EB1c

ADP + phosphorylated EB1c
the microtubule plus end protein
-
?
ATP + EB1c
ADP + phosphorylated EB1c
the microtubule plus end protein, recombinant GST-tagged substrate protein, phosphorylation on a threonine residue
-
?
ATP + Elk-1

ADP + phosphorylated Elk-1
an ETS family transcription factor
-
?
ATP + Elk-1
ADP + phosphorylated Elk-1
an ETS family transcription factor with modified D-site by swapping two hydrophobic residues
-
?
ATP + Elk-1
ADP + phosphorylated Elk-1
an ETS family transcription factor
-
?
ATP + Elk1

ADP + phosphorylated Elk1
-
recombinant GST-tagged Elk1, substrate of ERK2
-
?
ATP + Elk1
ADP + phosphorylated Elk1
-
-
-
?
ATP + Elk1
ADP + phosphorylated Elk1
the reaction is performed by activated phosphorylated ERK2
-
?
ATP + Elk1
ADP + phosphorylated Elk1
the reaction is performed by activated phosphorylated JNK3
-
?
ATP + Elk1
ADP + phosphorylated Elk1
recombinant GST-tagged substrate, the reaction is performed by activated phosphorylated ERK2
-
?
ATP + Elk1
ADP + phosphorylated Elk1
recombinant GST-tagged substrate, the reaction is performed by activated phosphorylated JNK3
-
?
ATP + Hot1p

ADP + phosphorylated Hot1p
-
substrate of Hog1p
-
?
ATP + Hot1p
ADP + phosphorylated Hot1p
-
substrate of Hog1p, phosphorylation of Hot1p is not required for Hot1p-mediated gene expression
-
?
ATP + human glucocorticoid receptor

ADP + phosphorylated human glucocorticoid receptor
-
specific phosphorylation at Ser211 by p38 MAPK, p38 MAPK is a mediator in glucocorticoid-induced apoptosis of lymphoid cells, interaction of MAPK and glucocorticoid pathways, overview
-
?
ATP + human glucocorticoid receptor
ADP + phosphorylated human glucocorticoid receptor
-
specific phosphorylation at Ser211 by p38 MAPK
-
?
ATP + Lin-1

ADP + phosphorylated Lin-1
substrate of ERK2, negative regulation of Lin-1
-
?
ATP + Lin-1
ADP + phosphorylated Lin-1
Lin-1 is an ETS transcription factor, substrate of ERK2, binding via the docking sequence of the substrate
-
?
ATP + MK2

ADP + phosphorylated MK2
-
-
-
?
ATP + MK2
ADP + phosphorylated MK2
-
-
?
ATP + MK2
ADP + phosphorylated MK2
-
-
?
ATP + MKS1

ADP + phosphorylated MSK1
-
MPK4 acts as a regulator of pathogen defense responses and is required for repression of salicylic acid-dependent resistance and for activation of jasmonate-dependent defense gene expression via MSK1, which interacts with the transcription factors WRKY25 and WRKY33
-
?
ATP + MKS1
ADP + phosphorylated MSK1
-
substrate of MPK4
-
?
ATP + MMP-9

ADP + phosphorylated MMP-9
-
activity of p38 MAP kinase, TNF-alpha stimulates MMP-9 expression via the p38 MAP kinase signaling pathway in 5637 cells, and p38 MAP kinase-mediated MMP-9 gene regulation in response to TNF-alpha is involved in the NF-kappaB response element in 5637 cells, regulation, overview
-
?
ATP + MMP-9
ADP + phosphorylated MMP-9
-
activity of p38 MAP kinase
-
?
ATP + multifunctional protein CAD

ADP + phosphorylated multifunctional protein CAD
-
CAD initiates and regulates de novo pyrimidine biosynthesis and is activated by phosphorylation at Thr456 by nuclear MAPKs, nuclear import of CAD is required for optimal cell growth
-
?
ATP + multifunctional protein CAD
ADP + phosphorylated multifunctional protein CAD
-
phosphorylation at Thr456, native and recombinant CAD
-
?
ATP + multifunctional protein CAD
ADP + phosphorylated multifunctional protein CAD
-
CAD initiates and regulates de novo pyrimidine biosynthesis and is activated by phosphorylation at Thr456 by nuclear MAPKs, nuclear import of CAD is required for optimal cell growth
-
?
ATP + multifunctional protein CAD
ADP + phosphorylated multifunctional protein CAD
-
phosphorylation at Thr456, native and recombinant multifunctional protein CAD
-
?
ATP + myelin basic protein

ADP + phosphorylated myelin basic protein
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
-
substrate in in vitro kinase assay
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
-
substrate of ERK2
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
-
-
-
?
ATP + Net

ADP + phosphorylated Net
an ETS family transcription factor
-
?
ATP + Net
ADP + phosphorylated Net
an ETS family transcription factor with modified D-site by swapping two hydrophobic residues
-
?
ATP + Net
ADP + phosphorylated Net
an ETS family transcription factor
-
?
ATP + phospholipase C-gamma1

ADP + phosphorylated phospholipase C-gamma1
the reaction is performed by activated phosphorylated ERK2, phosphorylation inhibits phospholipase C-gamma1
-
?
ATP + phospholipase C-gamma1
ADP + phosphorylated phospholipase C-gamma1
recombinant substrate, the reaction is performed by activated phosphorylated ERK2
-
?
ATP + protein

ADP + phosphoprotein
autophosphorylation
-
?
ATP + protein
ADP + phosphoprotein
autophosphorylates both Thr and Tyr residues
-
?
ATP + protein
ADP + phosphoprotein
Ser/Thr kinase
-
?
ATP + protein
ADP + phosphoprotein
autophosphorylation
-
?
ATP + protein
ADP + phosphoprotein
proline-directed kinase
-
?
ATP + protein
ADP + phosphoprotein
autophosphorylation on both tyrosine and threonine residues, autophosphorylation is probably involved in the MAP kinase activation process in vitro, but it may not be sufficient for full activation
-
?
ATP + protein ATF2

ADP + phosphorylated protein ATF2
-
recombinant GST-tagged ATF2 substrate
-
?
ATP + protein ATF2
ADP + phosphorylated protein ATF2
-
recombinant GST-tagged ATF2DELTA115
-
?
ATP + protein ATF2
ADP + phosphorylated protein ATF2
-
-
?
ATP + Smad1

ADP + phosphorylated Smad1
-
the MAP kinase antagonizes Smad1 in signaling during development of axis and neural specification, Smad1 is involved in dorsal-ventral patterning in embryos
-
?
ATP + Smad1
ADP + phosphorylated Smad1
-
phosphorylation by MAP kinase inhibits Smad1 and the BMP-4/Smad1 signaling pathway, phosphorylation sites are S187, S195, S205, and S213, activity with Smad1 mutant S187/S195/S205/S213, overview
-
?
ATP + Smad3

ADP + phosphorylated Smad3
-
substrate of MAPKs, e.g. ERK2
-
?
ATP + Smad3
ADP + phosphorylated Smad3
-
substrate of MAPKs, e.g. ERK2, identification of phosphorylation sites Ser203, Ser207, and Thr187, Ser207 is the best phosphorylation site for ERK2, other MAPKs than ERK2 also phosphorylate Ser212
-
?
ATP + Ste50

ADP + phosphorylated Ste50
Hog1 phosphorylates Ste50 in response to osmotic stress, and phosphorylation of Ste50 limits the duration of Kss1 activation and prevents invasive growth under high osmolarity growth conditions. The feedback phosphorylation event leads to more transient activation of Hog1, regulation, overview
-
?
ATP + Ste50
ADP + phosphorylated Ste50
Hog1 phosphorylates Ste50 in response to osmotic stress, and phosphorylation of Ste50 limits the duration of Kss1 activation and prevents invasive growth under high osmolarity growth conditions. The feedback phosphorylation event leads to more transient activation of Kss1, regulation, overview
-
?
ATP + tyrosine hydroxylase

ADP + phosphorylated tyrosine hydroxylase
-
phosphorylation of tyrosine hydroxylase at Ser8 and Ser31 by ERK1 and ERK2 is involved in regulation of catecholamine biosynthesis
-
?
ATP + tyrosine hydroxylase
ADP + phosphorylated tyrosine hydroxylase
-
recombinant rat wild-type and S8A, S31A, S19A, and S40A mutant tyrosine hydroxylase substrates, phosphorylation at Ser8 and Ser31 by ERK1 and ERK2, ERK2 prefers the Ser31 phosphorylation site, no activity with substrate mutant S8A/S31A
-
?
additional information

?
-
FLAG-tagged Arabidopsis thaliana proteins AT1G78150, AT2G26530, AT3G11330, and AT4G38710 are good MPK3/6 substrates, but are poor substrates for the closely related Arabidopsis thaliana MPK4
-
?
additional information
?
-
FLAG-tagged Arabidopsis thaliana proteins AT1G78150, AT2G26530, AT3G11330, and AT4G38710 are good MPK3/6 substrates, but are poor substrates for the closely related Arabidopsis thaliana MPK4
-
?
additional information
?
-
FLAG-tagged Arabidopsis thaliana proteins AT1G78150, AT2G26530, AT3G11330, and AT4G38710 are good MPK3/6 substrates, but are poor substrates for the closely related Arabidopsis thaliana MPK4
-
?
additional information
?
-
-
FLAG-tagged Arabidopsis thaliana proteins AT1G78150, AT2G26530, AT3G11330, and AT4G38710 are good MPK3/6 substrates, but are poor substrates for the closely related Arabidopsis thaliana MPK4
-
?
additional information
?
-
-
MPK6 interacts with gamma-tubulin and co-sediments with plant microtubules polymerized in vitro. The active form of MAP kinase is enriched with microtubules and follows similar dynamics to gamma-tubulin, moving from poles to midzone during the anaphase-to-telophase transition
-
?
additional information
?
-
MPK6 interacts with gamma-tubulin and co-sediments with plant microtubules polymerized in vitro. The active form of MAP kinase is enriched with microtubules and follows similar dynamics to gamma-tubulin, moving from poles to midzone during the anaphase-to-telophase transition
-
?
additional information
?
-
-
no activity with recombinant GST-tagged EB1a protein. MPK6 is recruited to gamma-tubulin or gamma-tubulin complexes, but no direct phosphorylation of either gamma-tubulin or gamma-tubulin complex protein GCP4 wby MPK6 is detectable in vitro
-
?
additional information
?
-
no activity with recombinant GST-tagged EB1a protein. MPK6 is recruited to gamma-tubulin or gamma-tubulin complexes, but no direct phosphorylation of either gamma-tubulin or gamma-tubulin complex protein GCP4 wby MPK6 is detectable in vitro
-
?
additional information
?
-
enzyme is activated in response to a variety of cellular stresses and is involved in apoptosis in neurons
-
?
additional information
?
-
-
enzyme is activated in response to a variety of cellular stresses and is involved in apoptosis in neurons
-
?
additional information
?
-
UNC-16 may regulate the localization of vesicular cargo by integrating JNK signaling and kinesin-1 transport
-
?
additional information
?
-
-
UNC-16 may regulate the localization of vesicular cargo by integrating JNK signaling and kinesin-1 transport
-
?
additional information
?
-
-
promoting influence of JNK-1 on both nuclear DAF-16 translocations and DAF-16 target gene sod-3, encoding superoxide dismutase 3, expressions within peripheral, non-neuronal tissue, JNK-1 modulates the intestinal stress-induced translocation of DAF-16 from the cytosol into the cell nucleus. JNK-1 is controlled by the MAPK JKK-1 under heat stress
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additional information
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promoting influence of JNK-1 on both nuclear DAF-16 translocations and DAF-16 target gene sod-3, encoding superoxide dismutase 3, expressions within peripheral, non-neuronal tissue, JNK-1 modulates the intestinal stress-induced translocation of DAF-16 from the cytosol into the cell nucleus. JNK-1 is controlled by the MAPK JKK-1 under heat stress
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additional information
?
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the mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans
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additional information
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the mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans
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additional information
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signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview
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additional information
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enzyme plays an important role in egg maturation or ectogenetic early development
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additional information
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enzyme plays an important role in egg maturation or ectogenetic early development
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additional information
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enzyme plays an important role in egg maturation or ectogenetic early development
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additional information
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possible role of asymmetric p38 activation in zebrafish in symmetric and synchronous cleavage
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additional information
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possible role of asymmetric p38 activation in zebrafish in symmetric and synchronous cleavage
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additional information
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possible role of asymmetric p38 activation in zebrafish in symmetric and synchronous cleavage
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additional information
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possible role of asymmetric p38 activation in zebrafish in symmetric and synchronous cleavage
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additional information
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spatiotemporal control of the Ras/ERK MAP kinase signaling pathway, involving multiple factors, is a key factor for determining the specificity of cellular responses including cell proliferation, cell differentiation, and cell survival, the fidelity of the signaling is regulated by docking interactions and by scaffolding, molecular mechanism of negative regulation of Ras/ERK signaling
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additional information
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ERK1 plays an essential role during the growth and differentiation
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additional information
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ERK1 plays an essential role during the growth and differentiation
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additional information
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JUN N-terminal kinase signaling is required to initiate the cell shape change at the onset of the epithelial wound healing. The embryonic JUN N-terminal kinase gene cassette is induced at the edge of the wound
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additional information
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functions of D-p38 is to attenuate antimicrobial peptide gene expression following exposure to lipopolysaccharide
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additional information
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functions of D-p38 is to attenuate antimicrobial peptide gene expression following exposure to lipopolysaccharide
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additional information
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DJNK signal transduction pathway mediates an immune response and morphogenesis
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additional information
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dorsal closure, a morphogenetic movement during Drosophila embryogenesis, is controlled by the Drosophila JNK pathway, D-Fos and the phosphatase Puckered
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additional information
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MAP kinase, ERK-A is required downstream of raf in the Sev signal transduction pathway
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additional information
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MAP kinase, ERK-A is required downstream of raf in the Sev signal transduction pathway
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additional information
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enzyme may function to modulate Dpp signaling
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additional information
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enzyme may function to modulate Dpp signaling
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additional information
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the JNK pathway is conserved and it is involved in controlling cell morphogenesis in Drosophila
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additional information
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during Drosophila embryogenesis, ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally. This process, dorsal closure, requires two signaling pathways: the Drosophila Jun-amino-terminal kinase pathway and the Dpp pathway
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additional information
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substrate specificity
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additional information
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enzyme is part of mitogen-activated protein kinase pathways, crosstalk and regulation mechanism, overview
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additional information
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poor activity on free amino acids, consensus sequence of ERK2 is P-XS/TP, substrate specificity and recognition elements, e.g. PXTP, the activity on the protein substrate is much higher compared to a 14-residue peptide containing the phosphorylation site
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additional information
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Gpmk1 MAP kinase regulates the induction of secreted lipolytic enzymes
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additional information
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Gpmk1 MAP kinase regulates the induction of secreted lipolytic enzymes
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additional information
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ceramide activation of mitochondrial p38 mitogen-activated protein kinase is a potential mechanism for loss of mitochondrial transmembrane potential and apoptosis
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?
additional information
?
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p38 MAPK, ERK1, and ERK2 are involved in regulation of connective tissue growth factor, CTGF, in chondrocyte maturation and function, particularly in the hypertrophic zone, as part of the retinoid and BMP signaling pathways, overview, p38 MAPK stimulates CTGF expression, while ERK1 and ERK2 supress it
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?
additional information
?
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no phosphorylation of the activation domain of c-Jun
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?
additional information
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no phosphorylation of the activation domain of c-Jun
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?
additional information
?
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no phosphorylation of the activation domain of c-Jun
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?
additional information
?
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no phosphorylation of MAPK-activated protein kinase-2 and -3
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?
additional information
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no phosphorylation of MAPK-activated protein kinase-2 and -3
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additional information
?
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enzyme is implicated in signal transduction pathways
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additional information
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enzyme is implicated in signal transduction pathways
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additional information
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enzyme is implicated in signal transduction pathways
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additional information
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BMK1 may regulate signaling events distinct from those controlled by the ERK group of enzymes
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additional information
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BMK1 may regulate signaling events distinct from those controlled by the ERK group of enzymes
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additional information
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the enzyme plays a crucial role in stress and inflammatory responses and is also involved in activation of the human immunodeficiency virus gene expression
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?
additional information
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the enzyme plays a crucial role in stress and inflammatory responses and is also involved in activation of the human immunodeficiency virus gene expression
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?
additional information
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JNK1 is a component of a novel signal transduction pathway that is activated by oncoproteins and UV irradiation, JNK1 activation may play an important role in tumor promotion
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?
additional information
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enzyme is involved in the signal transduction pathway initiated by proinflammatory cytokines and UV radiation
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?
additional information
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p493F12 gene maps to the human chromosome 21q21 region, a region that may be important in the pathogenesis of AD and Down's syndrome
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additional information
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p493F12 gene maps to the human chromosome 21q21 region, a region that may be important in the pathogenesis of AD and Down's syndrome
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additional information
?
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enzyme is activated by cellular stresses and plays an important role in regulating gene expression
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additional information
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enzyme is activated by cellular stresses and plays an important role in regulating gene expression
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additional information
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signaling pathway, including ERK, regulation, overview
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additional information
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the enzyme is part of a signalling cascade resulting in an increase in Ca2+-fluxes, activation of NF-kappaB, and expression of interleukin-8, the cascade is stimulated by pathogens, e.g. Pseudomonas aeruginosa PAO1 and Staphylococcus aureus RN6390, binding to asialo-glycolipid receptors, e.g. the asialoGM1 receptor, in epithelial membranes, no activation occurs with the pil mutant of Pseudomonas aeruginosa and the agr mutant of Staphylococcus aureus RN6911, Ca2+-dependent signaling, overview
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?
additional information
?
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interaction motifs of substrates are crucial for MAPK activity, motif Leu-Xaa-Leu preceded by 3-5 basic residues is abundant, docking mechanism in MAPK signalling, the recognition modules can function synergistically or competitively, MAPK determinants recognizing docking motifs, overview
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?
additional information
?
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MAPKs play a pivotal role in signal transduction
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additional information
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MAPKs, e.g. p38, play a key role in the transductin of biological signals from cell surface receptors, through the cytoplasm, to the transcriptional machinery in the nucleus
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?
additional information
?
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p38 isozymes are involved in multiple cellular functions such as cell proliferation, cell differentiation, apoptosis, and inflammation response, p38 expression and activity in signaling in erythroid cells is independent of erythropoietin
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?
additional information
?
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p38 MAP kinase mediates the activation of neutrophils and repression of TNF-alpha-induced apoptosis in response to inhibition by plasma opsonized crystals of calcium diphosphate dihydrate, p38 MAP kinase is involved in apoptosis of neutrophils, regulation overview
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?
additional information
?
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signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, aas well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview
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?
additional information
?
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the p38 MAPKalpha is involved in cell signal transduction and mediates responses to cell stresses and to growth factors
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?
additional information
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arsenic trioxide induces apoptosis and mitogen-activated protein kinases in promyelocytes and cancer cells. It enhances adhesion, migration, phagocytosis, release, and activity of gelatinase and degranulation of secretory, specific, and gelatinase, but not azurophilic granules, and is dependent upon activation of p38 and/or JNK. Activation of p38 and JNK is not associated with the ability of arsenic trioxide to induce human neutrophil apoptosis, overview
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?
additional information
?
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-
cadmium induces neuronal apoptosis in part through activation of Erk1, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk1 pathway, mechanism, overview
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?
additional information
?
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cadmium induces neuronal apoptosis in part through activation of Erk1, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk1 pathway, mechanism, overview
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?
additional information
?
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cadmium induces neuronal apoptosis in part through activation of Erk1, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk1 pathway, mechanism, overview
-
?
additional information
?
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-
cadmium induces neuronal apoptosis in part through activation of Erk2, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk2 pathway, mechanism, overview
-
?
additional information
?
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cadmium induces neuronal apoptosis in part through activation of Erk2, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk2 pathway, mechanism, overview
-
?
additional information
?
-
cadmium induces neuronal apoptosis in part through activation of Erk2, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk2 pathway, mechanism, overview
-
?
additional information
?
-
-
cadmium induces neuronal apoptosis in part through activation of JNK, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of JNK pathway, mechanism, overview
-
?
additional information
?
-
cadmium induces neuronal apoptosis in part through activation of JNK, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of JNK pathway, mechanism, overview
-
?
additional information
?
-
cadmium induces neuronal apoptosis in part through activation of JNK, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of JNK pathway, mechanism, overview
-
?
additional information
?
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JNK2 shows conformational flexibility in the MAP kinase insert and its involvement in the regulation of catalytic activity, the MAP kinase insert of JNK2 plays a role in the regulation of JNK2 activation, possibly by interacting with intracellular binding partners, overview
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?
additional information
?
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JNK2 shows conformational flexibility in the MAP kinase insert and its involvement in the regulation of catalytic activity, the MAP kinase insert of JNK2 plays a role in the regulation of JNK2 activation, possibly by interacting with intracellular binding partners, overview
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?
additional information
?
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-
p38 MAP kinase inhibitor SB203580 decreases TNF-alpha-mediated DNA binding activity of NF-?B, which is is involved in p38MAP kinase-mediated control of the MMP-9 gene in 5637 cells, overview
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?
additional information
?
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p38 MAPK is a central signaling molecule in many proinflammatory pathways, regulating the cellular response to a multitude of external stimuli including heat, ultraviolet radiation, osmotic shock, and a variety of cytokines especially interleukin-1beta and tumor necrosis factor alpha
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additional information
?
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p38 MAPK is a central signaling molecule in many proinflammatory pathways, regulating the cellular response to a multitude of external stimuli including heat, ultraviolet radiation, osmotic shock, and a variety of cytokines especially interleukin-1beta and tumor necrosis factor alpha
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?
additional information
?
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The mitogen-activated protein kinase p38 is a key regulator in the signaling pathways controlling the production of pro-inflammatory cytokines such as TNF-alpha and IL-1beta
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?
additional information
?
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The mitogen-activated protein kinase p38 is a key regulator in the signaling pathways controlling the production of pro-inflammatory cytokines such as TNF-alpha and IL-1beta
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?
additional information
?
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MAPKs that are in different families (e.g. ERK, JNK, and p38) can bind selectively to D-sites in their authentic substrates and regulators while discriminating against D-sites in other pathways. The short hydrophobic region at the distal end of the D-site plays a critical role in determining the high selectivity of JNK MAPKs for docking sites in their cognate MAPK kinases. These specificity-determining differences are also found in the D-sites of the ETS family transcription factors Elk-1 and Net. Swapping two hydrophobic residues between these D-sites switches the relative efficiency of Elk-1 and Net as substrates for ERK versus JNK. Comparison of the hydrophobic submotif in strong versus weak JNK-binding D-sites, overview. The D-sites of the JNK pathway activator MKK4 contains LXL, as do all three of the D-sites in activator MKK7 in the first 3 residues of the hydrophobic submotif. MKK D-sites that bind JNK weakly lack an extended hydrophobic motif
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?
additional information
?
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MAPKs that are in different families (e.g. ERK, JNK, and p38) can bind selectively to D-sites in their authentic substrates and regulators while discriminating against D-sites in other pathways. The short hydrophobic region at the distal end of the D-site plays a critical role in determining the high selectivity of JNK MAPKs for docking sites in their cognate MAPK kinases. These specificity-determining differences are also found in the D-sites of the ETS family transcription factors Elk-1 and Net. Swapping two hydrophobic residues between these D-sites switches the relative efficiency of Elk-1 and Net as substrates for ERK versus JNK. Comparison of the hydrophobic submotif in strong versus weak JNK-binding D-sites, overview. The D-sites of the JNK pathway activator MKK4 contains LXL, as do all three of the D-sites in activator MKK7 in the first 3 residues of the hydrophobic submotif. MKK D-sites that bind JNK weakly lack an extended hydrophobic motif
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?
additional information
?
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MAPKs that are in different families (e.g. ERK, JNK, and p38) can bind selectively to D-sites in their authentic substrates and regulators while discriminating against D-sites in other pathways. The short hydrophobic region at the distal end of the D-site plays a critical role in determining the high selectivity of JNK MAPKs for docking sites in their cognate MAPK kinases. These specificity-determining differences are also found in the D-sites of the ETS family transcription factors Elk-1 and Net. Swapping two hydrophobic residues between these D-sites switches the relative efficiency of Elk-1 and Net as substrates for ERK versus JNK. Comparison of the hydrophobic submotif in strong versus weak JNK-binding D-sites, overview. The D-sites of the JNK pathway activator MKK4 contains LXL, as do all three of the D-sites in activator MKK7 in the first 3 residues of the hydrophobic submotif. MKK D-sites that bind JNK weakly lack an extended hydrophobic motif
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?
additional information
?
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p38beta can autophosphorylate and thus autoactivate itself, the C tail of p38beta inhibits autophosphorylation
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?
additional information
?
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p38beta can autophosphorylate and thus autoactivate itself, the C tail of p38beta inhibits autophosphorylation
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?
additional information
?
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the enzyme depends on basic residues for substrate recognition, autoregulation by a pseudosubstrate mechanism, overview
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?
additional information
?
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MAPK pathways overview, interaction of MAPKs and transcription factors, overview, the MAPKs act as structural adaptors and enzymatic activators in transcription complexes, e.g. ERK1 and ERK2 interact with AP1-complex, which is regulated via the all-trans retinoic acid receptor and TPA, overview
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?
additional information
?
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transcription factor protein domains consisting of the LXL motif, the FXFP motif, the LXLXXXF motif, or the ETS motif, are involved in stable interaction of MAPKs with transcription complexes
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?
additional information
?
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kinase activation may play a role in the mitogenic induction of symbiotic root nodules on alfalfa by Rhizobium signal molecules
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?
additional information
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kinase activation may play a role in the mitogenic induction of symbiotic root nodules on alfalfa by Rhizobium signal molecules
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?
additional information
?
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-
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?
additional information
?
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-
-
?
additional information
?
-
-
-
?
additional information
?
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-
-
-
?
additional information
?
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Jnk3-mediated signalling pathway is an important component in the pathogenesis of glutamate neurotoxicity
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?
additional information
?
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MKK4 is a JNK activator in vivo and an essential component of the JNK signal transduction pathway
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?
additional information
?
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JNK is necessary for T-cell differentiation but not for naive T-cell activation
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?
additional information
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-
JNK is necessary for T-cell differentiation but not for naive T-cell activation
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?
additional information
?
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the enzyme functions as a Scaffold factor in the JNK signaling pathway
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?
additional information
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the enzyme functions as a Scaffold factor in the JNK signaling pathway
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?
additional information
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the enzyme functions as a Scaffold factor in the JNK signaling pathway
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?
additional information
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the enzyme functions as a Scaffold factor in the JNK signaling pathway
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?
additional information
?
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ERK, but not p38 and JNK, is involved in TGF-beta production in macrophages, the phosphatidylserine-receptor is involved in the ERK signaling pathway, overview
-
?
additional information
?
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-
regulation mechanism of p38 MAPK activity involving the protein kinases MKK3, MKK4, and MKK6, overview
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?
additional information
?
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-
signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview
-
?
additional information
?
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-
measurement of ATPase activity of p38 MAPK in an NADH-coupled assay
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?
additional information
?
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-
activated p39 MAPK inhibits steroid synthesis in adrenocortical Y1-BS1 cells, overview
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?
additional information
?
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activated p39 MAPK inhibits steroid synthesis in adrenocortical Y1-BS1 cells, overview
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?
additional information
?
-
activated p39 MAPK inhibits steroid synthesis in adrenocortical Y1-BS1 cells, overview
-
?
additional information
?
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activation of JNK facilitates tumour necrosis factor-induced cell death. The p38 mitogen-activated protein kinase pathway is induced by TNF-stimulation, but it is not involved in TNF-induced cell death. p38alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure. p38alpha MAPK inhibits MKK4, and MKK3/6, regulation, overview
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?
additional information
?
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-
MAP kinases are essential signaling molecules that mediate many cellular effects of growth factors, cytokines, and stress stimuli
-
?
additional information
?
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-
MAPKs are involved in the upstream regulation of inducible nitric oxide synthase, iNOS
-
?
additional information
?
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p38 MAPK is induced in response to environmental stress, it is implicated in diverse cellular processes, including cell proliferation, differentiation, and survival of differentiated cells in the central nervous system, expression profile and roles of p38 MAPK in the developing brain, overview. Inhibitors of p38 mitogen-activated protein kinase enhance proliferation of mouse neural stem cells, overview
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?
additional information
?
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trauma-hemorrhage suppresses MAPK phosphorylation and activation in lipopolysaccharide-unstimulated splenic dendritic cells, in lipopolysaccharide-unstimulated cells the activation is increased, modeling, overview
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?
additional information
?
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trauma-hemorrhage suppresses MAPK phosphorylation and activation in lipopolysaccharide-unstimulated splenic dendritic cells, in lipopolysaccharide-unstimulated cells the activation is increased, modeling, overview
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?
additional information
?
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trauma-hemorrhage suppresses MAPK phosphorylation and activation in lipopolysaccharide-unstimulated splenic dendritic cells, in lipopolysaccharide-unstimulated cells the activation is increased, modeling, overview
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?
additional information
?
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trauma-hemorrhage suppresses MAPK phosphorylation and activation in lipopolysaccharide-unstimulated splenic dendritic cells, in lipopolysaccharide-unstimulated cells the activation is increased, modeling, overview
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?
additional information
?
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trauma-hemorrhage suppresses MAPK phosphorylation and activation in lipopolysaccharide-unstimulated splenic dendritic cells, in lipopolysaccharide-unstimulated cells the activation is increased, modelling, overview
-
?
additional information
?
-
trauma-hemorrhage suppresses MAPK phosphorylation and activation in lipopolysaccharide-unstimulated splenic dendritic cells, in lipopolysaccharide-unstimulated cells the activation is increased, modelling, overview
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?
additional information
?
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trauma-hemorrhage suppresses MAPK phosphorylation and activation in lipopolysaccharide-unstimulated splenic dendritic cells, in lipopolysaccharide-unstimulated cells the activation is increased, modelling, overview
-
?
additional information
?
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trauma-hemorrhage suppresses MAPK phosphorylation and activation in lipopolysaccharide-unstimulated splenic dendritic cells, in lipopolysaccharide-unstimulated cells the activation is increased, modelling, overview
-
?
additional information
?
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activation of JNK facilitates tumour necrosis factor-induced cell death. The p38 mitogen-activated protein kinase pathway is induced by TNF-stimulation, but it is not involved in TNF-induced cell death. p38alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure. p38alpha MAPK inhibits MKK4, and MKK3/6, regulation, overview
-
?
additional information
?
-
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signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview
-
?
additional information
?
-
MAPK cascades play a key role in plant growth and development as well as in biotic and abiotic stress responses
-
?
additional information
?
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MAPK cascades play a key role in plant growth and development as well as in biotic and abiotic stress responses
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?
additional information
?
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PMK1 is part of a highly conserved MAP kinase signal transduction pathway that acts cooperatively with a cAMP signaling pathway for fungal pathogenesis
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?
additional information
?
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PMK1 is part of a highly conserved MAP kinase signal transduction pathway that acts cooperatively with a cAMP signaling pathway for fungal pathogenesis
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?
additional information
?
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p38-delta is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7, suggesting that p38-delta is a unique stress-responsive protein kinase
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?
additional information
?
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the enzyme is involved in regulating the response of eukaryotic cells to extracellular signals
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?
additional information
?
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the enzyme plays a crucial role in stress and inflammatory responses and is also involved in activation of the human immunodeficiency virus gene expression
-
?
additional information
?
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p38 MAPK, but not ERKs or JNKs, regulates the serotonin transporter, SERT, and subsequent signaling induced by 5-hydroxytryptamine, overview
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?
additional information
?
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signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, aas well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview
-
?
additional information
?
-
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tert-butyl hydroperoxide activation of MAPK might be involved in vascular dysfunction in oxidative stress responses and the vascular inflammatory process
-
?
additional information
?
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-
MAPK phosphorylation consensus sequences
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?
additional information
?
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MAPK phosphorylation consensus sequences
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?
additional information
?
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stoichiometry of phosphorylation of wild-type and mutant tyrosine hydroxylase substrates by ERK2
-
?
additional information
?
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-
cadmium induces neuronal apoptosis in part through activation of Erk1, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk1 pathway, mechanism, overview
-
?
additional information
?
-
cadmium induces neuronal apoptosis in part through activation of Erk1, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk1 pathway, mechanism, overview
-
?
additional information
?
-
cadmium induces neuronal apoptosis in part through activation of Erk1, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk1 pathway, mechanism, overview
-
?
additional information
?
-
-
cadmium induces neuronal apoptosis in part through activation of Erk2, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk2 pathway, mechanism, overview
-
?
additional information
?
-
cadmium induces neuronal apoptosis in part through activation of Erk2, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk2 pathway, mechanism, overview
-
?
additional information
?
-
cadmium induces neuronal apoptosis in part through activation of Erk2, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk2 pathway, mechanism, overview
-
?
additional information
?
-
-
cadmium induces neuronal apoptosis in part through activation of JNK, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of JNK pathway, mechanism, overview
-
?
additional information
?
-
cadmium induces neuronal apoptosis in part through activation of JNK, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of JNK pathway, mechanism, overview
-
?
additional information
?
-
cadmium induces neuronal apoptosis in part through activation of JNK, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of JNK pathway, mechanism, overview
-
?
additional information
?
-
enzyme is required for the transition from mitosis into conjugation
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?
additional information
?
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enzyme is required for restoring the osmotic gradient across the cell membrane
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?
additional information
?
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enzyme is required for restoring the osmotic gradient across the cell membrane
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?
additional information
?
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enzyme is involved in polarized cell growth
-
?
additional information
?
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enzyme is involved in polarized cell growth
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enzyme is required for spore wall assembly
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enzyme is required for spore wall assembly
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signal transduction in Saccharomyces cerevisiae requires Tyr and Thr phosphorylation of FUS3 and KSS1
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signal transduction in Saccharomyces cerevisiae requires Tyr and Thr phosphorylation of FUS3 and KSS1
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DAC2/FUS3 protein kinase is not essential for transcriptional activation of the mating pheromone response pathway
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enzyme is involved in growth control pathway
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Hog1 is related to osmotic stress
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the enzyme performs autophosporylation
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Fus3, Kss1, and Hog1 function during the mating pheromone response, the switch of filamentous growth, and the response to high osmolarity, respectively, detailed pathway overview, MAPK signaling pathways and specificity, pathway sequestering mechanism modeling, separation via subcellular compartmentalization, temporal separation, scaffolding, combinatorial signaling, detailed overview
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MAPK pathways overview, the MAPKs act as structural adaptors and enzymatic activators in transcription complexes, e.g. Hog1p, Hot1p, and Sko1p, overview
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transcription factor protein domains consisting of the LXL motif, the FXFP motif, the LXLXXXF motif, or the ETS motif, are involved in stable interaction of MAPKs with transcription complexes
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kinase activity of Hog1 is required to promote its own dephosphorylation after hyperosmotic-stress-induced activation, moreover, catalytic activity of Hog1 is required continuously to prevent cross talk between the the high-osmolarity glycerol pathway and both the pheromone response and invasive growth pathways
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the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Hog1 activity is transient and promotes cell adaptation to osmotic stress, Ste50 is a target for feedback regulation of the two pathways, overview. Hog1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview
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the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Hog1 activity is transient and promotes cell adaptation to osmotic stress, Ste50 is a target for feedback regulation of the two pathways, overview. Hog1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview
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the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Hog1 activity is transient and promotes cell adaptation to osmotic stress, Ste50 is a target for feedback regulation of the two pathways, overview. Hog1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview
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the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Kss1 activity is sustained and promotes invasive growth, Ste50 is a target for feedback regulation of the two pathways, overview. Kss1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview
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the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Kss1 activity is sustained and promotes invasive growth, Ste50 is a target for feedback regulation of the two pathways, overview. Kss1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview
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the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Kss1 activity is sustained and promotes invasive growth, Ste50 is a target for feedback regulation of the two pathways, overview. Kss1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview
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enzyme plays a pivotal role in a variety of signal transduction pathways
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enzyme plays a pivotal role in a variety of signal transduction pathways
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enzyme functions as a part of the fission yeast growth control pathway
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the enzyme regulates cell integrity and functions coordinately with the protein kinase C pathway
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the enzyme regulates cell integrity and functions coordinately with the protein kinase C pathway
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stress-activated MAP kinase regulates morphogenesis in Schizosaccharomyces pombe
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stress-activated MAP kinase regulates morphogenesis in Schizosaccharomyces pombe
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conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast
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conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast
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acts downstream of the Wis1 MAP kinase kinase to control cell size at division in fission yeast
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acts downstream of the Wis1 MAP kinase kinase to control cell size at division in fission yeast
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signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview
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a peptide docking sequence derived from either a downstream substrate or an upstream activator is appended to an ERK substrate peptide to yield a high-efficiency substrate for ERK without loss of specificity
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the enzyme is involved in biocontrol properties and repression of conidiation of the fungal hosts in the dark, effects of wild-type and mutant enzymes on host growth, morphology, and conidiation, overview
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the enzyme is involved in biocontrol properties and repression of conidiation of the fungal hosts in the dark, effects of wild-type and mutant enzymes on host growth, morphology, and conidiation, overview
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spatiotemporal control of the Ras/ERK MAP kinase signaling pathway, involving multiple factors, is a key factor for determining the specificity of cellular responses including cell proliferation, cell differentiation, and cell survival, the fidelity of the signaling is regulated by docking interactions and by scaffolding, molecular mechanism of negative regulation of Ras/ERK signaling
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MAP kinase functions as an intermediate between MPF and the interphase-M phase transition of microtubule organization
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RKK, RK, and MAPKAP kinase-2 constitute a new stress-activated signal transduction pathway in vertebrates that is distinct from the classical MAPK cascade
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