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Literature summary for 2.7.11.24 extracted from

  • Andreasson, E.; Jenkins, T.; Brodersen, P.; Thorgrimsen, S.; Petersen, N.H.; Zhu, S.; Qiu, J.L.; Micheelsen, P.; Rocher, A.; Petersen, M.; Newman, M.A.; Bjorn Nielsen, H.; Hirt, H.; Somssich, I.; Mattsson, O.; Mundy, J.
    The MAP kinase substrate MKS1 is a regulator of plant defense responses (2005), EMBO J., 24, 2579-2589.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene mpk4, gene expression profiling, overexpression of mpk4 leads to increased expression of the genes PR1 and PR2, encoding plant defense proteins, and of the ICS1 gene, encoding a salicylic acid biosynthetic enzyme Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information overexpression of MPK4 substrate MSK1 in wild-type plants leads to activated salicylic-dependent resistance, but does not interfere with induction of a defense gene by jasmonate Arabidopsis thaliana

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + MKS1 Arabidopsis thaliana MPK4 acts as a regulator of pathogen defense responses and is required for repression of salicylic acid-dependent resistance and for activation of jasmonate-dependent defense gene expression via MSK1, which interacts with the transcription factors WRKY25 and WRKY33 ADP + phosphorylated MSK1
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + MKS1 MPK4 acts as a regulator of pathogen defense responses and is required for repression of salicylic acid-dependent resistance and for activation of jasmonate-dependent defense gene expression via MSK1, which interacts with the transcription factors WRKY25 and WRKY33 Arabidopsis thaliana ADP + phosphorylated MSK1
-
?
ATP + MKS1 substrate of MPK4 Arabidopsis thaliana ADP + phosphorylated MSK1
-
?
ATP + WRKY25 the transcription factor is an in vitro substrate of MPK4 Arabidopsis thaliana ADP + phosphorylated WRKY25
-
?
ATP + WRKY33 the transcription factor is an in vitro substrate of MPK4 Arabidopsis thaliana ADP + phosphorylated WRKY33
-
?

Synonyms

Synonyms Comment Organism
MAP kinase 4
-
Arabidopsis thaliana
MPK4
-
Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
ATP
-
Arabidopsis thaliana