Application | Comment | Organism |
---|---|---|
medicine | JNK1 has emerged as an attractive target for diabetes therapy, since JNK1 is believed to play a key role in linking obesity and insulin resistance | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3R)-3-([4-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]pyrimidin-2-yl]amino)butanoic acid | - |
Homo sapiens | |
3-([4-[3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl]amino)cyclohexanol | - |
Homo sapiens | |
4-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-N-(1-methylethyl)pyrimidin-2-amine | - |
Homo sapiens | |
4-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-N-(1-methylpiperidin-4-yl)pyrimidin-2-amine | - |
Homo sapiens | |
4-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-N-cyclohexylpyrimidin-2-amine | - |
Homo sapiens | |
4-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-N-cyclopentylpyrimidin-2-amine | - |
Homo sapiens | |
4-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-N-cyclopropylpyrimidin-2-amine | - |
Homo sapiens | |
4-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-N-methylpyrimidin-2-amine | - |
Homo sapiens | |
N-(1-methylethyl)-4-(1H-pyrazol-4-yl)pyrimidin-2-amine | - |
Homo sapiens | |
N-(1-methylethyl)-4-(3-piperidin-3-yl-1H-pyrazol-4-yl)pyrimidin-2-amine | - |
Homo sapiens | |
N-(1-methylethyl)-4-[3-(6-methylpyridin-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine | - |
Homo sapiens | |
N-(1-methylethyl)-4-[3-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine | - |
Homo sapiens | |
N-(1-methylethyl)-4-[3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine | - |
Homo sapiens | |
N-(1-methylethyl)-4-[3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine | - |
Homo sapiens | |
N-(1-methylethyl)-4-[3-[1-(methylsulfonyl)piperidin-4-yl]-1H-pyrazol-4-yl]pyrimidin-2-amine | - |
Homo sapiens | |
N-cyclopentyl-4-[3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine | - |
Homo sapiens | |
N-[trans-4-([4-[3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl]amino)cyclohexyl]acetamide | - |
Homo sapiens | |
N-[trans-4-([4-[3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl]amino)cyclohexyl]methanesulfonamide | - |
Homo sapiens | |
trans-4-([4-[3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl]amino)cyclohexanol | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? | |
ATP + IRS-1 | phosphorylation of the insulin receptor substrate IRS-1 at serine 307 | Homo sapiens | ADP + phosphorylated IRS-1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
c-Jun N-terminal kinase | - |
Homo sapiens |
c-Jun N-terminal kinase 2 | - |
Homo sapiens |
c-Jun N-terminal kinase 3 | - |
Homo sapiens |
JNK | - |
Homo sapiens |
JNK1 | - |
Homo sapiens |
JNK2 | - |
Homo sapiens |
JNK3 | - |
Homo sapiens |
MAP kinase | - |
Homo sapiens |
mitogen-activated kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000009 | - |
N-[trans-4-([4-[3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl]amino)cyclohexyl]methanesulfonamide | - |
Homo sapiens | |
0.000012 | - |
trans-4-([4-[3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl]amino)cyclohexanol | - |
Homo sapiens | |
0.000012 | - |
N-cyclopentyl-4-[3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine | - |
Homo sapiens | |
0.000016 | - |
trans-4-([4-[3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl]amino)cyclohexanol | - |
Homo sapiens | |
0.000017 | - |
trans-4-([4-[3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl]amino)cyclohexanol | - |
Homo sapiens | |
0.000026 | - |
4-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-N-cyclopentylpyrimidin-2-amine | - |
Homo sapiens | |
0.000027 | - |
4-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-N-cyclohexylpyrimidin-2-amine | - |
Homo sapiens | |
0.000028 | - |
N-[trans-4-([4-[3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl]amino)cyclohexyl]acetamide | - |
Homo sapiens | |
0.000036 | - |
3-([4-[3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl]amino)cyclohexanol | - |
Homo sapiens | |
0.000043 | - |
N-(1-methylethyl)-4-[3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine | - |
Homo sapiens | |
0.000048 | - |
4-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-N-(1-methylethyl)pyrimidin-2-amine | - |
Homo sapiens | |
0.000101 | - |
N-(1-methylethyl)-4-[3-[1-(methylsulfonyl)piperidin-4-yl]-1H-pyrazol-4-yl]pyrimidin-2-amine | - |
Homo sapiens | |
0.000151 | - |
4-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-N-cyclopropylpyrimidin-2-amine | - |
Homo sapiens | |
0.000162 | - |
N-(1-methylethyl)-4-[3-(6-methylpyridin-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine | - |
Homo sapiens | |
0.000169 | - |
N-(1-methylethyl)-4-[3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine | - |
Homo sapiens | |
0.000315 | - |
(3R)-3-([4-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]pyrimidin-2-yl]amino)butanoic acid | - |
Homo sapiens | |
0.000381 | - |
N-(1-methylethyl)-4-[3-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine | - |
Homo sapiens | |
0.00053 | - |
N-(1-methylethyl)-4-(3-piperidin-3-yl-1H-pyrazol-4-yl)pyrimidin-2-amine | - |
Homo sapiens | |
0.00157 | - |
4-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-N-(1-methylpiperidin-4-yl)pyrimidin-2-amine | - |
Homo sapiens | |
0.00206 | - |
4-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-N-methylpyrimidin-2-amine | - |
Homo sapiens | |
0.00273 | - |
N-(1-methylethyl)-4-(1H-pyrazol-4-yl)pyrimidin-2-amine | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000098 | - |
- |
Homo sapiens | trans-4-([4-[3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl]amino)cyclohexanol | |
0.000114 | - |
- |
Homo sapiens | N-[trans-4-([4-[3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl]amino)cyclohexyl]methanesulfonamide | |
0.000209 | - |
- |
Homo sapiens | 3-([4-[3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl]amino)cyclohexanol | |
0.000221 | - |
- |
Homo sapiens | N-(1-methylethyl)-4-[3-[1-(methylsulfonyl)piperidin-4-yl]-1H-pyrazol-4-yl]pyrimidin-2-amine | |
0.000245 | - |
- |
Homo sapiens | N-cyclopentyl-4-[3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine | |
0.000299 | - |
- |
Homo sapiens | N-[trans-4-([4-[3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl]amino)cyclohexyl]acetamide | |
0.000357 | - |
- |
Homo sapiens | N-(1-methylethyl)-4-[3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine | |
0.00046 | - |
- |
Homo sapiens | 4-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-N-cyclopentylpyrimidin-2-amine | |
0.000814 | - |
- |
Homo sapiens | N-(1-methylethyl)-4-[3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine | |
0.00084 | - |
- |
Homo sapiens | 4-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-N-cyclopropylpyrimidin-2-amine | |
0.00092 | - |
- |
Homo sapiens | 4-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-N-(1-methylethyl)pyrimidin-2-amine | |
0.0011 | - |
- |
Homo sapiens | 4-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-N-cyclohexylpyrimidin-2-amine | |
0.0035 | - |
- |
Homo sapiens | N-(1-methylethyl)-4-[3-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine | |
0.00602 | - |
- |
Homo sapiens | N-(1-methylethyl)-4-[3-(6-methylpyridin-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | JNK activity is elevated in adipocytes of type 2 diabetic patients | up |
General Information | Comment | Organism |
---|---|---|
physiological function | JNK1 disrupts the insulin signaling cascade via phosphorylation of the insulin receptor substrate IRS-1, which leads to the degradation of IRS-1 | Homo sapiens |