Literature summary for 2.7.11.24 extracted from

Naidu, S.; Sutherland, C.; Zhang, Y.; Risco, A.; de la Vega, L.; Caunt, C.; Hastie, C.; Lamont, D.; Torrente, L.; Chowdhry, S.; Benjamin, I.; Keyse, S.; Cuenda, A.; Dinkova-Kostovaa, A.
Heat shock factor 1 is a substrate for p38 mitogen-activated protein kinases (2016), Mol. Cell. Biol., 36, 2403-2417 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
MKK6	-	Homo sapiens
phenethyl isothiocyanate	the enzyme is activated by exposure to 0.02 mM phenethyl isothiocyanate	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
BIRB0796	-	Homo sapiens
SB202190	isoform p38alpha/beta inhibitor	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	-	Homo sapiens

Purification (Commentary)

Purification (Comment)	Organism
glutathione-Sepharose column chromatography	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
MDA-MB-231 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + heat shock factor 1	phosphorylation at Ser-326, Ser-303 and Ser-307, better substrate for p38gamma than for any of the other p38 isoforms	Homo sapiens	ADP + phosphorylated heat shock factor 1	-	?

Synonyms

Synonyms	Comment	Organism
MAPK	-	Homo sapiens
MEK	-	Homo sapiens
p38	-	Homo sapiens
p38alpha	isoform	Homo sapiens
p38beta	isoform	Homo sapiens
p38delta	isoform	Homo sapiens
p38gamma	isoform	Homo sapiens

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Release 2023.1 (January 2023)