Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | osmotic stress activates Hog1. Ste11 is a MAP kinase kinase kinase upstream of Hog1. Ste50 is an adaptor protein required for the catalytic activity of Ste11 | Saccharomyces cerevisiae | |
additional information | osmotic stress activates Kss1. Ste11 is a MAP kinase kinase kinase upstream of Kss1. Ste50 is an adaptor protein required for the catalytic activity of Ste11 | Saccharomyces cerevisiae |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Ste50 | Saccharomyces cerevisiae | Hog1 phosphorylates Ste50 in response to osmotic stress, and phosphorylation of Ste50 limits the duration of Kss1 activation and prevents invasive growth under high osmolarity growth conditions. The feedback phosphorylation event leads to more transient activation of Hog1, regulation, overview | ADP + phosphorylated Ste50 | - |
? | |
ATP + Ste50 | Saccharomyces cerevisiae | Hog1 phosphorylates Ste50 in response to osmotic stress, and phosphorylation of Ste50 limits the duration of Kss1 activation and prevents invasive growth under high osmolarity growth conditions. The feedback phosphorylation event leads to more transient activation of Kss1, regulation, overview | ADP + phosphorylated Ste50 | - |
? | |
additional information | Saccharomyces cerevisiae | the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Hog1 activity is transient and promotes cell adaptation to osmotic stress, Ste50 is a target for feedback regulation of the two pathways, overview. Hog1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview | ? | - |
? | |
additional information | Saccharomyces cerevisiae | the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Kss1 activity is sustained and promotes invasive growth, Ste50 is a target for feedback regulation of the two pathways, overview. Kss1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | P14681 | Kss1 | - |
Saccharomyces cerevisiae | P32485 | Hog1 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | Ste11 is a MAP kinase kinase kinase upstream of Hog1. Ste50 is an adaptor protein required for the catalytic activity of Ste11 | Saccharomyces cerevisiae |
phosphoprotein | Ste11 is a MAP kinase kinase kinase upstream of Kss1. Ste50 is an adaptor protein required for the catalytic activity of Ste11 | Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Ste50 | Hog1 phosphorylates Ste50 in response to osmotic stress, and phosphorylation of Ste50 limits the duration of Kss1 activation and prevents invasive growth under high osmolarity growth conditions. The feedback phosphorylation event leads to more transient activation of Hog1, regulation, overview | Saccharomyces cerevisiae | ADP + phosphorylated Ste50 | - |
? | |
ATP + Ste50 | Hog1 phosphorylates Ste50 in response to osmotic stress, and phosphorylation of Ste50 limits the duration of Kss1 activation and prevents invasive growth under high osmolarity growth conditions. The feedback phosphorylation event leads to more transient activation of Kss1, regulation, overview | Saccharomyces cerevisiae | ADP + phosphorylated Ste50 | - |
? | |
additional information | the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Hog1 activity is transient and promotes cell adaptation to osmotic stress, Ste50 is a target for feedback regulation of the two pathways, overview. Hog1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview | Saccharomyces cerevisiae | ? | - |
? | |
additional information | the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Kss1 activity is sustained and promotes invasive growth, Ste50 is a target for feedback regulation of the two pathways, overview. Kss1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview | Saccharomyces cerevisiae | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Hog1 | - |
Saccharomyces cerevisiae |
Kss1 | - |
Saccharomyces cerevisiae |
MAP kinase | - |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Saccharomyces cerevisiae |