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Literature summary for 2.7.11.24 extracted from

  • Ding, Z.; Li, M.; Sun, F.; Xi, P.; Sun, L.; Zhang, L.; Jiang, Z.
    Mitogen-activated protein kinases are associated with the regulation of physiological traits and virulence in Fusarium oxysporum f. sp. cubense (2015), PLoS ONE, 10, e0122634.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene FOIG_09199 or FoSlt2, DNA and amino acid sequence determination and analysis, phylogenetic analysis Fusarium oxysporum f. sp. cubense

Protein Variants

Protein Variants Comment Organism
additional information generation of the knockout mutant DELTAFoSlt2 by targeted gene disruption, complementation with the wild-type gene Fusarium oxysporum f. sp. cubense

Organism

Organism UniProt Comment Textmining
Fusarium oxysporum f. sp. cubense X0JB59 tropical race 4 54006
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Fusarium oxysporum f. sp. cubense XJZ2 X0JB59 tropical race 4 54006
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Source Tissue

Source Tissue Comment Organism Textmining
hypha
-
 Fusarium oxysporum f. sp. cubense
-
additional information in silico analysis of the MAP kinase gene FOIG_09199 Fusarium oxysporum f. sp. cubense
-

Subunits

Subunits Comment Organism
More the enzyme contains the conserved catalytic domain of the serine/threonine kinases Fusarium oxysporum f. sp. cubense

Synonyms

Synonyms Comment Organism
FOIG_09199
-
 Fusarium oxysporum f. sp. cubense
FoSlt2
-
 Fusarium oxysporum f. sp. cubense
MAP kinase
-
 Fusarium oxysporum f. sp. cubense
Slt2
-
 Fusarium oxysporum f. sp. cubense

General Information

General Information Comment Organism
evolution the enzyme contains the conserved catalytic domain of the serine/threonine kinases Fusarium oxysporum f. sp. cubense
malfunction the enzyme knockout mutant shows colonies that are smaller and more compact thant the wild-type colonies. Additionally, while the wild-type produces abundant aerial hyphae on PDA plates, the mutant produces fewer and shorter aerial hyphae. Although mutation of the MAP kinase gene shows substantial effect on the fungal hyphal structure and colony morphology, the conidia produced by the mutant are similar to the wild-type with normal size and morphology. The mutant has reduced production of chitin and reduced expression levels of chitin biosynthetic genes. The mutant DELTAFoSlt2 shows lower chitin contents than wild-type and complemented strain DELTAFoSlt2-c. The mutant strain also shows reduced levels of different chitin syntases, overview. The mutant is sensitive to H2O2. The siderophore biosynthetic gene sidA is 2fold upregulated in mutant DELTAFoSlt2. The expression levels of beauvericin biosynthetic genes, beas, kivr and abc3, are significantly reduced in mutants DELTAFoSlt2 by 12fold, 4fold, and 5fold, respectively as compared to the wild-type, while the expression of fusaric acid biosynthetic genes FUB1 to FUB5 is significantly reduced in the mutant by 100fold, 11fold, 10fold, 25fold, and 50fold, respectively. Hyphal growth rates of the mutant DELTAFoSlt2 is reduced on solid media but not affected in liquid media Fusarium oxysporum f. sp. cubense
physiological function the enzyme is involved in siderophore biosynthesis and plays a vital role in regulation of fusaric acid production. The MAP kinase is necessary for the fungal virulence on banana plants and is required for the full virulence of Fusarium oxysporum f. sp. cubense Fusarium oxysporum f. sp. cubense