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Literature summary for 2.7.11.24 extracted from

  • Pocivavsek, A.; Rebeck, G.W.
    Inhibition of c-Jun N-terminal kinase increases apoE expression in vitro and in vivo (2009), Biochem. Biophys. Res. Commun., 387, 516-520.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.24

Application

Application Comment Organism
medicine targeting JNK inhibition in the CNS may prove to protect against neurodegenerative insults, by either inhibiting JNK activation in neurons associated with increased apoptosis or preventing the inflammatory response in glial cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
SP600125
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Mus musculus
-
 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Mus musculus
-
brain
-
 Mus musculus
-
brain cortex
-
 Mus musculus
-
glia mixed glial cultures Mus musculus
-
hippocampus
-
 Mus musculus
-
microglia
-
 Mus musculus
-
neuron
-
 Mus musculus
-
oligodendrocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Mus musculus ADP + a phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
c-Jun N-terminal kinase
-
 Mus musculus
JNK
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus