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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.24C177S/C222S/K250A/K251A/K265A/K270A site-directed mutagenesis, the hexa-surfaced mutant forms crystallization complexes with inhibitor furan-2-carboxylic acid (3-[5-(4H-[1,2,4]triazol-3-yl)-1H-indazol-3-yl]-phenyl)-amide in contrast to other mutant variants or the wild-type enzyme 693668
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.24D144A kinase-dead mutant, is unable to grow on 1000 mM sorbitol 679590
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.24D176A active p38alpha mutant, crystals do not appear spontaneously, cross-seeding approaches using crystals of mutant D176A+F327L as the source of microseeds results in crystals suitable for X-ray analysis 677321
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.24D176A site-directed mutagenesis of p38beta, the intrinsically active variant is spontaneously phosphorylated and active toward MK2, the mutant manifests elevated catalytic activity when immunoprecipitated from cells not exposed to any activating signal 740723
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.24D176A/F327L most active p38alpha mutant, improvement of crystallization assays, obtained with abolishing phosphorylation completely by reducing both the temperature and duration of induction and by significantly shortening the N-terminal hexahistidine spacer, facilitating the growth of well diffracting crystals 677321
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.24D176A/F327S active p38alpha mutant, crystals do not appear spontaneously, cross-seeding approaches using crystals of mutant D176A+F327L as the source of microseeds results in crystals suitable for X-ray analysis 677321
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.24D176A/F327S site-directed mutagenesis of p38alpha, the intrinsically active variant is spontaneously phosphorylated and active toward MK2, the mutant manifests elevated catalytic activity when immunoprecipitated from cells not exposed to any activating signal 740723
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.24D3K/C6V/S8N/14E site-directed mutagenesis using JNK2 1-362 or 1-364, the mutant does not crystallize 693668
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.24D546V site-directed mutagenesis, the mutant enzyme is exclusively localized in the nucleus and especially in the Golgi apparatus, not in the cytoplasm, in contrast to the wild-type enzyme 666292
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.24E339A in 100 mM KCl completely dimeric 678159
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