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Literature summary for 2.7.11.24 extracted from

  • Champelovier, P.; El Atifi, M.; Pautre, V.; Rostaing, B.; Berger, F.; Seigneurin, D.
    Specific inhibition of basal mitogen-activated protein kinases and phosphatidylinositol 3 kinase activities in leukemia cells: a possible therapeutic role for the kinase inhibitors (2007), Exp. Hematol., 36, 28-36.
    View publication on PubMed

Application

Application Comment Organism
drug development kinase inhibitors modulate proliferation of leukemia cells, the MEK/ERK inhibitor, PD098059, in combination with either SP600125, an inhibitor of N-terminal c-jun kinases, or LY294002, a PI3K inhibitor, could have clinical value Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
PD098059 selective inhibitor of mitogen-activated extracellular regulated kinase phosphorylation, arrests cells in G(0)/G(1), increases P21/waf1 antigen expression Homo sapiens
SB203580 P38 MAPK inhibitor, has no effect on cell proliferation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukemia cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
p38 MAPK
-
Homo sapiens