Application | Comment | Organism |
---|---|---|
drug development | kinase inhibitors modulate proliferation of leukemia cells, the MEK/ERK inhibitor, PD098059, in combination with either SP600125, an inhibitor of N-terminal c-jun kinases, or LY294002, a PI3K inhibitor, could have clinical value | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
PD098059 | selective inhibitor of mitogen-activated extracellular regulated kinase phosphorylation, arrests cells in G(0)/G(1), increases P21/waf1 antigen expression | Homo sapiens | |
SB203580 | P38 MAPK inhibitor, has no effect on cell proliferation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leukemia cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
p38 MAPK | - |
Homo sapiens |