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Literature summary for 2.7.11.24 extracted from

  • Zhou, C.H.; Wu, X.H.; Wu, Y.Q.
    Nobiletin, a dietary phytochemical, inhibits vascular smooth muscle cells proliferation via calcium-mediated c-Jun N-terminal kinases pathway (2009), Eur. J. Pharmacol., 615, 55-60.
    View publication on PubMed
Search for more literature for 2.7.11.24

Activating Compound

Activating Compound Comment Organism Structure
angiotensin II
-
 Bos taurus

Application

Application Comment Organism
medicine inhibition of JNK by nobiletin may imply its usefulness for the treatment of cardiovascular diseases relevant to vascular smooth muscle cells growth Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
anthra[1-9-cd]pyrazol-6(2H)-one SP600125 Bos taurus
nobiletin inhibits angiotensin II-induced activation of JNK Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Ca2+ dependent activation of JNK in vascular smooth muscle cells Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Bos taurus
-
 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
vascular smooth muscle cell obtained from thoracic aorta Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Bos taurus ADP + a phosphoprotein
-
 ?
ATP + c-Jun activity assay Bos taurus ADP + phosphorylated c-Jun
-
 ?

Synonyms

Synonyms Comment Organism
c-Jun N-terminal kinase
-
 Bos taurus
JNK
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Bos taurus