Application | Comment | Organism |
---|---|---|
medicine | role in immune response to the spirochete of Borrelia burgdorferi mediated by CD4+ T cells, p38 MAP kinase pathway mediates production of IFN-gamma in response to a specific antigen, IL-12 contributes to IFN-gamma production by Borrelia burgdorferi specific effector Th1 cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | transgenic mice expressing a dominant negative mutant MAP kinase, inhibits the activity of endogenous p38 MAP kinase and reduces levels of IFN-gamma in serum | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
SB203580 | inhibits p38 MAP kinase in T cells, administration of the pharmacological inhibitor of the kinase during the course of infection with the spirochete Borrelia burgdorferi results in reduced levels of IFN-gamma in the sera of infected mice | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C3H/HeN mice | - |
Mus musculus C3H/HEN | - |
C3H/HeN mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | CD4+ T cell | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
MAP kinase | - |
Mus musculus |
p38 mitogen-activated protein MAP kinase | - |
Mus musculus |