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EC Number
Activating Compound
Commentary
Reference
2.7.11.24
12-O-tetradecanoylphorbol-13-acetate
activates ERK1 and ERK2
665798
2.7.11.24
abscisic acid
ABA
706382
2.7.11.24
ADAMTS4
EC 3.4.24.82
697804
2.7.11.24
amitriptyline
up-regulates ERK1/2 phosphorylation and activity 8fold at 0.01 mM, the addition of nor-binaltorphimine (100 nM) reduces the amitriptyline stimulatory effect by 70%
705322
2.7.11.24
angiotensin II
-
703567
2.7.11.24
arsenite
treatment of worms with arsenite, a toxic ROS-producing compound, induces a robust phosphorylation of PMK-1, induction of oxidative stress-responsive genes, and eventual lethality. Activation of PMK-1 following arsenite treatment is dependent on SEK-1 but independent of NSY-1, differing from the NSY-1/SEK-1/PMK-1 cascade used during infection and osmotic stress
740759
2.7.11.24
beta-phorbol-13-acetate
stimulates SERT phosphorylation
666131
2.7.11.24
citrinin
the exposure of HEK-293 and HeLa cells to citrinin results in a dose-dependent increase in the phosphorylation of ERK1/2 and JNK
701309
2.7.11.24
cytokines
-
491718
2.7.11.24
cytokines
activate
491717
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