Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.24 extracted from

  • Hanajiri, K.; Mitsui, H.; Maruyama, T.; Hashimoto, N.; Sata, M.; Omata, M.
    Echographic detection of diethylnitrosamine-induced liver tumors in rats and the effect of the intratumoral injection of an inhibitor of c-Jun N-terminal kinase (2009), J. Gastroenterol. Hepatol., 24, 866-871.
    View publication on PubMed
Search for more literature for 2.7.11.24

Activating Compound

Activating Compound Comment Organism Structure
additional information JNK is activated by cellular stress, cytokines, and growth factors Rattus norvegicus

Application

Application Comment Organism
medicine c-Jun N-terminal kinase might be another therapeutic target in liver neoplasms Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
SP600125
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Rattus norvegicus
-
 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male wistar rat
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-
liver cancer cell diethylnitrosamine-induced liver tumor Rattus norvegicus
-
McA-RH7777 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Rattus norvegicus ADP + a phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
c-Jun N-terminal kinase
-
 Rattus norvegicus
JNK
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function involved in the pathways of apoptosis and growth Rattus norvegicus