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Literature summary for 2.7.11.24 extracted from

  • Chung, E.J.; Brown, A.P.; Asano, H.; Mandler, M.; Burgan, W.E.; Carter, D.; Camphausen, K.; Citrin, D.
    In vitro and in vivo radiosensitization with AZD6244 (ARRY-142886), an inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 kinase (2009), Clin. Cancer Res., 15, 3050-3057.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information the MAPK pathway is also activated after exposure to ionizing radiation Homo sapiens

Application

Application Comment Organism
medicine results indicate that AZD6244 can enhance tumor cell radiosensitivity in vitro and in vivo and suggest that this effect involves an increase in mitotic catastrophe Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
AZD6244 ARRY-142886, MEK1/2 inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Homo sapiens
-
 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
DU-145 cell
-
 Homo sapiens
-
MiaPaCa-2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Homo sapiens ADP + a phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
ERK1/2
-
 Homo sapiens
MAP kinase
-
 Homo sapiens
MAPK
-
 Homo sapiens
MEK1/2
-
 Homo sapiens
mitogen-activated kinase
-
 Homo sapiens
mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the MAPK pathway is often up-regulated in cancers up

General Information

General Information Comment Organism
physiological function the MAPK pathway is important for cell proliferation, survival and differentiation Homo sapiens