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Literature summary for 2.7.11.24 extracted from

  • Kong, J.Y.; Klassen, S.S.; Rabkin, S.W.
    Ceramide activates a mitochondrial p38 mitogen-activated protein kinase: a potential mechanism for loss of mitochondrial transmembrane potential and apoptosis (2005), Mol. Cell. Biochem., 278, 39-51.
    View publication on PubMed
Search for more literature for 2.7.11.24

Activating Compound

Activating Compound Comment Organism Structure
additional information p38 MAPK is activated by phosphorylation Gallus gallus
N-acetylsphingosine i.e. C2-ceramide, an intracellular mediator of apoptosis, cell-permeable N-acetylsphingosine activates mitochondrial p38 MAPK Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by PD98059 Gallus gallus
SB202190 specific p38 MAPK inhibitor Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol p38 MAPK Gallus gallus 5829
-
mitochondrion p38 MAPK Gallus gallus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Gallus gallus ceramide activation of mitochondrial p38 mitogen-activated protein kinase is a potential mechanism for loss of mitochondrial transmembrane potential and apoptosis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein p38 MAPK is activated by phosphorylation Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
cardiac myocyte
-
 Gallus gallus
-
embryo ventricular cells Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ceramide activation of mitochondrial p38 mitogen-activated protein kinase is a potential mechanism for loss of mitochondrial transmembrane potential and apoptosis Gallus gallus ?
-
 ?

Synonyms

Synonyms Comment Organism
p38 MAPK
-
 Gallus gallus