Any feedback?
Literature summary for 2.7.11.24 extracted from
- A p38 mitogen-activated protein kinase inhibitor screening method using growth recovery of Escherichia coli as an index (2009), Anal. Biochem., 388, 128-133.
Application
| Application | Comment | Organism |
|---|---|---|
| analysis | a concept and implementation of a new simple inhibitor screening method applicable for a broad range of human proteins by using transformed bacteria is reported | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| into the plasmid pRSET-CA for expression in Escherichia coli Bl21DE3 cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K53A | kinase-negative mutant | Homo sapiens |
| T106M | inhibitor-insensitive mutant | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| SB202190 | benzyl coumarin derivative | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| GST- and His-tags are used in the purification experiments | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| mitogen-activated kinase | - |
Homo sapiens |
| p38 | - |
Homo sapiens |
| p38 MAP kinase | - |
Homo sapiens |
| p38 mitogen-activated protein kinase | - |
Homo sapiens |
| p38 protein | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
