Application | Comment | Organism |
---|---|---|
medicine | the inhibitors of Erk1 or antioxidants may be exploited for prevention of cadmium-induced neurodegenerative diseases | Rattus norvegicus |
medicine | the inhibitors of Erk1 or antioxidants may be exploited for prevention of cadmium-induced neurodegenerative diseases | Homo sapiens |
medicine | the inhibitors of Erk2 or antioxidants may be exploited for prevention of cadmium-induced neurodegenerative diseases | Homo sapiens |
medicine | the inhibitors of Erk2, or antioxidants may be exploited for prevention of cadmium-induced neurodegenerative diseases | Rattus norvegicus |
medicine | the inhibitors of JNK or antioxidants may be exploited for prevention of cadmium-induced neurodegenerative diseases | Homo sapiens |
medicine | the inhibitors of JNK, or antioxidants may be exploited for prevention of cadmium-induced neurodegenerative diseases | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | overexpression of PP2A or PP5 partially prevents Cd-induced activation of Erk1; overexpression of PP2A or PP5 partially prevents Cd-induced activation of Erk2; overexpression of PP2A or PP5 partially prevents Cd-induced activation of JNK | Homo sapiens | |
additional information | overexpression of PP2A or PP5 partially prevents Cd-induced activation of Erk1; overexpression of PP2A or PP5 partially prevents Cd-induced activation of Erk2; overexpression of PP2A or PP5 partially prevents Cd-induced activation of JNK | Rattus norvegicus | |
SP600125 | inhibitor of JNK | Homo sapiens | |
SP600125 | inhibitor of JNK | Rattus norvegicus | |
U0126 | inhibitor of Erk1; inhibitor of Erk2 | Homo sapiens | |
U0126 | inhibitor of Erk1; inhibitor of Erk2 | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | cadmium induces neuronal apoptosis in part through activation of Erk1, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk1 pathway, mechanism, overview | ? | - |
? | |
additional information | Homo sapiens | cadmium induces neuronal apoptosis in part through activation of Erk1, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk1 pathway, mechanism, overview | ? | - |
? | |
additional information | Homo sapiens | cadmium induces neuronal apoptosis in part through activation of Erk2, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk2 pathway, mechanism, overview | ? | - |
? | |
additional information | Rattus norvegicus | cadmium induces neuronal apoptosis in part through activation of Erk2, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk2 pathway, mechanism, overview | ? | - |
? | |
additional information | Homo sapiens | cadmium induces neuronal apoptosis in part through activation of JNK, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of JNK pathway, mechanism, overview | ? | - |
? | |
additional information | Rattus norvegicus | cadmium induces neuronal apoptosis in part through activation of JNK, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of JNK pathway, mechanism, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P27361 | Erk1 | - |
Homo sapiens | P28482 | ERK2 | - |
Rattus norvegicus | - |
- |
- |
Rattus norvegicus | P21708 | Erk1 | - |
Rattus norvegicus | P63086 | ERK2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuroblastoma cell | - |
Homo sapiens | - |
PC-12 cell | - |
Rattus norvegicus | - |
SH-SY5Y cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | cadmium induces neuronal apoptosis in part through activation of Erk1, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk1 pathway, mechanism, overview | Rattus norvegicus | ? | - |
? | |
additional information | cadmium induces neuronal apoptosis in part through activation of Erk1, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk1 pathway, mechanism, overview | Homo sapiens | ? | - |
? | |
additional information | cadmium induces neuronal apoptosis in part through activation of Erk2, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk2 pathway, mechanism, overview | Homo sapiens | ? | - |
? | |
additional information | cadmium induces neuronal apoptosis in part through activation of Erk2, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk2 pathway, mechanism, overview | Rattus norvegicus | ? | - |
? | |
additional information | cadmium induces neuronal apoptosis in part through activation of JNK, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of JNK pathway, mechanism, overview | Homo sapiens | ? | - |
? | |
additional information | cadmium induces neuronal apoptosis in part through activation of JNK, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of JNK pathway, mechanism, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
c-Jun N-terminal kinase | - |
Homo sapiens |
c-Jun N-terminal kinase | - |
Rattus norvegicus |
ERK1 | - |
Rattus norvegicus |
ERK1 | - |
Homo sapiens |
ERK2 | - |
Homo sapiens |
ERK2 | - |
Rattus norvegicus |
extracellular signal-regulated kinase 1 | - |
Rattus norvegicus |
extracellular signal-regulated kinase 1 | - |
Homo sapiens |
extracellular signal-regulated kinase 2 | - |
Homo sapiens |
extracellular signal-regulated kinase 2 | - |
Rattus norvegicus |
JNK | - |
Homo sapiens |
JNK | - |
Rattus norvegicus |
MAPK | - |
Homo sapiens |
MAPK | - |
Rattus norvegicus |