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Literature summary for 2.7.11.24 extracted from

  • Bind, E.; Kleyner, Y.; Skowronska-Krawczyk, D.; Bien, E.; Dynlacht, B.D.; Sanchez, I.
    A novel mechanism for mitogen-activated protein kinase localization (2004), Mol. Biol. Cell, 15, 4457-4466.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.24

Cloned(Commentary)

Cloned (Comment) Organism
expression of GFP-tagged wild-type and mutant ERK3 in human Hela and T98G cells, and in rat 2 cells, fluorescent immunoaffinity subcellular localization study Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
D546V site-directed mutagenesis, the mutant enzyme is exclusively localized in the nucleus and especially in the Golgi apparatus, not in the cytoplasm, in contrast to the wild-type enzyme Rattus norvegicus
K717S site-directed mutagenesis, the mutant enzyme is exclusively localized in the nucleus and Golgi apparatus, not in the cytoplasm, in contrast to the wild-type enzyme Rattus norvegicus
additional information Construction of several truncation mutants Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm cytoplasmic MAPKs, e.g. ERK3, translocate to the nucleus subsequent to their phosphorylation by their activating MAPK kinases, EC 2.7.11.25 Rattus norvegicus 5737
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Golgi apparatus ERK3 is targeted to the Golgi or endoplasmic reticulum as an intermediate compartment during translocation from cytoplasm to nucleus, ERK3 possesses a C-terminally targeting motif for the Golgi apparatus Rattus norvegicus 5794
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additional information subcellular localization of wild-type and mutant enzymes, overview, ERK3 translocates from cytoplasm to the nucleus in a temporally regulated exit from a membraneous organelle, nuclear translocation is cell cycle-dependent, mechanism Rattus norvegicus
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nucleus cytoplasmic MAPKs, e.g. ERK3, translocate to the nucleus subsequent to their phosphorylation by their activating MAPK kinases, EC 2.7.11.25 Rattus norvegicus 5634
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
100000
-
 x * 100000, about, recombinant ERK3, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P27704
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-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein MAPKs are phosphorylated by their activating MAPK kinases, EC 2.7.11.25 Rattus norvegicus

Subunits

Subunits Comment Organism
? x * 100000, about, recombinant ERK3, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
ERK3
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 Rattus norvegicus