Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.24 extracted from

  • Brancho, D.; Tanaka, N.; Jaeschke, A.; Ventura, J.J.; Kelkar, N.; Tanaka, Y.; Kyuuma, M.; Takeshita, T.; Flavell, R.A.; Davis, R.J.
    Mechanism of p38 MAP kinase activation in vivo (2003), Genes Dev., 17, 1969-1978.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information mechanism of p38 MAP kinase activation in vivo, coordinated and selective actions of protein kinases MKK3, MKK4, and MKK6 in response to cytokines and exposure to environmental stress are part of the regulation, overview Mus musculus
TNF-alpha activates p38 MAPK mediated by protein kinases MKK3, MKK4, and MKK6, overview Mus musculus
UV radiation activates p38 MAPK mediated by protein kinases, overview Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information enzyme-deficient mutant mice show defects in growth arrest and increased tumorigenesis Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus regulation mechanism of p38 MAPK activity involving the protein kinases MKK3, MKK4, and MKK6, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information regulation mechanism of p38 MAPK activity involving the protein kinases MKK3, MKK4, and MKK6, overview Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
p38 MAP kinase
-
Mus musculus
p38 MAPK
-
Mus musculus