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Literature summary for 2.7.11.24 extracted from

  • Ni, H.; Sheng, X.; Cui, X.; Gu, M.; Liu, Y.; Qi, X.; Xing, S.; Guo, Y.
    Epidermal growth factor-mediated mitogen-activated protein kinase3/1 pathway is conducive to in vitro maturation of sheep oocytes (2015), PLoS ONE, 10, e0120418.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information phosphorylation of the enzyme by MAPK kinase MEK activates the enzyme. U0126, a specific inhibitor of MEK (MAPK kinase), blocks the activation of MAPK3/1 and subsequently of EGF-mediated downstream MAPK3/1 pathway Ovis aries

Inhibitors

Inhibitors Comment Organism Structure
additional information phosphorylation of the enzyme by MAPK kinase MEK activates the enzyme. U0126, a specific inhibitor of MEK (MAPK kinase), blocks the activation of MAPK3/1 and subsequently of EGF-mediated downstream MAPK3/1 pathway Ovis aries

Organism

Organism UniProt Comment Textmining
Ovis aries W5P0L9
-
-
Ovis aries W5Q1R8
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of the enzyme by MAPK kinase MEK activates the enzyme Ovis aries

Source Tissue

Source Tissue Comment Organism Textmining
oocyte
-
 Ovis aries
-

Synonyms

Synonyms Comment Organism
ERK1
-
 Ovis aries
ERK2
-
 Ovis aries
MAPK1
-
 Ovis aries
MAPK3
-
 Ovis aries
mitogen-activated protein kinase 1
-
 Ovis aries
mitogen-activated protein kinase 3
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 Ovis aries

General Information

General Information Comment Organism
physiological function effect of EGF-mediated mitogen-activated protein kinases 3 and 1 (MAPK3/1) pathway on in vitro cytoplasmic maturation of sheep oocytes, overview. The key downstream effectors of EGFR signaling in cumulus cells, mitogen-activated protein kinases 3 and 1 (MAPK3/1, also known as ERK1/2), is essential for mammalian oocyte maturation. Maturation of mammalian oocytes is a complex and dynamic process involving the maturation of nucleus and cytoplasm Ovis aries