Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | PD 98059 inhibits EGF-induced nuclear translocation of CAD | Homo sapiens | |
additional information | PD98059 inhibits EGF-induced nuclear translocation of multifunctional protein CAD | Mesocricetus auratus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | CAD occurs in the cytoplasm and the nucleus, but is phosphorylated only in the nucleus, CAD translocation is induced by EGF stimulation | Homo sapiens | - |
- |
additional information | multifunctional protein CAD occurs in the cytoplasm and the nucleus, but is phosphorylated only in the nucleus, CAD translocation is induced by EGF stimulation | Mesocricetus auratus | - |
- |
nuclear matrix | - |
Homo sapiens | 16363 | - |
nuclear matrix | - |
Mesocricetus auratus | 16363 | - |
nucleus | - |
Homo sapiens | 5634 | - |
nucleus | - |
Mesocricetus auratus | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens | |
Mg2+ | - |
Mesocricetus auratus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + multifunctional protein CAD | Homo sapiens | CAD initiates and regulates de novo pyrimidine biosynthesis and is activated by phosphorylation at Thr456 by nuclear MAPKs, nuclear import of CAD is required for optimal cell growth | ADP + phosphorylated multifunctional protein CAD | - |
? | |
ATP + multifunctional protein CAD | Mesocricetus auratus | CAD initiates and regulates de novo pyrimidine biosynthesis and is activated by phosphorylation at Thr456 by nuclear MAPKs, nuclear import of CAD is required for optimal cell growth | ADP + phosphorylated multifunctional protein CAD | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mesocricetus auratus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
293 cell | - |
Homo sapiens | - |
BHK-21 cell | - |
Mesocricetus auratus | - |
breast | - |
Homo sapiens | - |
breast cancer cell | - |
Homo sapiens | - |
embryonic kidney cell line | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
kidney | - |
Mesocricetus auratus | - |
MCF-10A cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
mesothelioma cell | - |
Homo sapiens | - |
MSTO-211H cell | mesothelioma cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + multifunctional protein CAD | CAD initiates and regulates de novo pyrimidine biosynthesis and is activated by phosphorylation at Thr456 by nuclear MAPKs, nuclear import of CAD is required for optimal cell growth | Homo sapiens | ADP + phosphorylated multifunctional protein CAD | - |
? | |
ATP + multifunctional protein CAD | CAD initiates and regulates de novo pyrimidine biosynthesis and is activated by phosphorylation at Thr456 by nuclear MAPKs, nuclear import of CAD is required for optimal cell growth | Mesocricetus auratus | ADP + phosphorylated multifunctional protein CAD | - |
? | |
ATP + multifunctional protein CAD | phosphorylation at Thr456, native and recombinant CAD | Homo sapiens | ADP + phosphorylated multifunctional protein CAD | - |
? | |
ATP + multifunctional protein CAD | phosphorylation at Thr456, native and recombinant multifunctional protein CAD | Mesocricetus auratus | ADP + phosphorylated multifunctional protein CAD | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAP kinase | - |
Homo sapiens |
MAP kinase | - |
Mesocricetus auratus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Mesocricetus auratus |