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Literature summary for 2.7.11.24 extracted from
- Kinetic and catalytic mechanisms of protein kinases (2001), Chem. Rev., 101, 2271-2290.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | activation mechanism, phosphorylation/activation of ERK1 and ERK2 by the MAPK kinase-1 | eukaryota |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| ERK2, X-ray diffraction structure analysis | eukaryota |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | p38alpha: kinetic mechanism, reaction kinetics can be influenced by the sort of substrate | eukaryota |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cd2+ | can partially substitue Mg2+ | eukaryota |  |
| Co2+ | can partially substitue Mg2+ | eukaryota | |
| Mg2+ | dependent on, Mg2+ is the physiologic metal ion, other divalent cations are able to support nucleotide binding, but only Mn2+, Co2+, and Cd2+ can substitute Mg2+ in supporting the catalytic activity | eukaryota | |
| Mn2+ | can partially substitue Mg2+ | eukaryota | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | eukaryota | - |
ADP + a phosphoprotein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| eukaryota | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | regulation by phosphorylation of the activation loop, increases substrate and ATP binding as well as the phosphotransfer rate, phosphorylation/activation of ERK1 and ERK2 by the MAPK kinase-1 | eukaryota |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate | reaction mechanism | eukaryota |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | - |
eukaryota | ADP + a phosphoprotein | - |
? | |
| ATP + a protein | ERK2 phosphorylates MBP, p38 phosphorylates the protein substrate MAPKAP2 and the peptide substrate KRELVEPLTPSGEAPNQALLR, other substrates of MAPK are transcription factors, such as c-Jun, ATF-2, and MEF2A | eukaryota | ADP + a phosphoprotein | - |
? | |
| additional information | poor activity on free amino acids, consensus sequence of ERK2 is P-XS/TP, substrate specificity and recognition elements, e.g. PXTP, the activity on the protein substrate is much higher compared to a 14-residue peptide containing the phosphorylation site | eukaryota | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ERK1 | - |
eukaryota |
| ERK2 | - |
eukaryota |
| extracellular-regulated kinase-1 | - |
eukaryota |
| extracellular-regulated kinase-2 | - |
eukaryota |
| MAP kinase | - |
eukaryota |
| MAPK | - |
eukaryota |
| p38 | - |
eukaryota |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | dependent on | eukaryota | |
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