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Literature summary for 2.7.11.24 extracted from

  • Liu, W.; Liang, Q.; Balzar, S.; Wenzel, S.; Gorska, M.; Alam, R.
    Cell-specific activation profile of extracellular signal-regulated kinase 1/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airways (2008), J. Allergy Clin. Immunol., 121, 893-902.e2.
    View publication on PubMed
Search for more literature for 2.7.11.24

Activating Compound

Activating Compound Comment Organism Structure
additional information phosphorylation activates MAPKs, PD98059 inhibits ERK1/2 phosphorylation by MEK1/2, i.e. mitogen-activated kinase-extracellular signal-regulated kinase kinase, p38 MAPK is activated in asthma patient airway cells, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P27361 Erk1
-
Homo sapiens P28482 ERK2
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation activates MAPKs, PD98059 inhibits ERK1/2 phosphorylation by MEK1/2, i.e. mitogen-activated kinase-extracellular signal-regulated kinase kinase Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell from airway tissue Homo sapiens
-
additional information distribution of phosphorylated active MAPKs in airway tissues of healthy persons and of paients with mild or severe asthma, phosphorylated p38 is increased in epithelium of asthmatic samples, overview Homo sapiens
-
respiratory tract
-
 Homo sapiens
-
smooth muscle
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
ERK1
-
 Homo sapiens
ERK2
-
 Homo sapiens
extracellular regulated kinase
-
 Homo sapiens
MAPK
-
 Homo sapiens
p38 MAPK
-
 Homo sapiens